双功能有机小分子模拟酯酶研究

设计并合成了3个含有硫脲和咪唑基团的双功能有机小分子催化剂, 运用紫外光谱研究了它们对乙酸对硝基苯酯(PNPA)水解的催化活性. 考察了不同的pH条件下, 催化速率常数的变化情况. 发现与硫脲单功能催化剂相比, 双功能有机小分子催化剂具有更高的催化活性.     

碘催化的亚胺Diels-Alder反应：有效地合成四氢喹啉衍生物

Iodine was found to be an efficient catalyst for the imino Diels-Alder reaction of N-arylimine with enol ethers toprovide tetrahydroquinolines in good yields.The influence of the loading of iodine,reaction solvent,the structure ofimine and enol ethers was studied.One pot synthesis of tetrahydroquinolines from aldehyde,aniline and enol etherscatalyzed by iodine was also applicable and provided tetrahydroquinolines in comparable yields.Mild reaction con-ditions,facile experimental procedure,low price of iodine and good yield of products render this new method at-tractive for practical synthesis of many tetrahydroquinoline derivatives.