黏滞阻尼器在超高层结构体系中的效率研究

250m以上的超高层结构主要有框架-核心筒、框筒-核心筒和巨型框架-核心筒等三种结构体系．由于超高层结构的高宽比通常较大（5以上）,结构的侧向变形往往成为控制因素．随着消能减震技术的不断成熟,黏滞阻尼器越来越多的应用于建筑结构领域．本文分别将黏滞阻尼器均匀布置在上述三种超高层结构体系中,对比其消能减震效果并分析原因,最后建议了黏滞阻尼器在这些结构中的较优布置．     

TETRAHYDROPROTOBERBERINE—A NEW CHEMICAL TYPE OF ANTAGONIST OF DOPAMINE RECEPTORS

In rats lesioned by unilateral micro-injection of 6-OHDA into substantia nigra, the apomorphine-induced contralateral rotation and the amphetamine-induced ipsilateral rotation were antagonized by THB, l-THP and haloperidol. Scopolamine reversed the antagonistic effect of THB against amphetamine. Thus, THB and 1-THP exhibited the DA-receptor antagonistic property which was similar to that of haloperidol.l-SPD (10mg/kg), however, only antagonized the amphetamine-challenged rotational response, while it could not antagonize, but potentiate, the apomorphine-challenged rotational response. So, l-SPD might be a partial agonistie antagonist of DA-receptors, and its effect was more potent than that of THB and l-THP. l-SPD would be ascertained further in clinic trial.From these results and others, the authors suggest that THPB is a new chemical type of antagonist of brain DA-receptors.     

新化学类型的脑内多巴胺受体阻滞剂——四氢原小檗碱同类物

用6-羟基多巴胺单侧损毁大鼠黑质-纹状体的DA通径,使双侧对称的DA功能失去平衡,在去水吗啡或苯丙胺诱发下,大鼠分别出现向健侧或损侧的旋转运动。与氟哌啶醇一样,四氢小檗碱和左旋四氢巴马汀能拮抗上述两种旋转作用,呈现DA受体阻滞剂的作用;而千金藤定碱拮抗苯丙胺的旋转活动作用比前两者强3—5倍,但它能协同去水吗啡的旋转活动。本文的工作,从生理行为效应证明它们是脑内多巴胺受体的阻滞剂。它们均属于四氢原小檗碱的同类物,是未见报道的新化学类型的DA阻滞剂,值得重视。