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Role of brain Ca~(2+) in electro-acupuncture analgesia and the development of analgesic tolerance to electro-acupuncture and morphine were studied. At the same time, the inhibition by protein synthesis inhibiturs of the development of analgesic tolerance to electro-acupuncture was observed. The results showed that like morphine tolerance, the brain Ca~(2+) and cAMP levels in mice were enhanced with the development of analgesic tolerance to electro-acupuncture. After treatment with protein synthesis inhibitors anisomycin, actinomycin or cycloheximide the development of analgesic tolerance to electro-acupuncture was inhibited, and concurrently, the brain Ca~(2+) and cAMP levels in the animals greatly reduced. From the changes of brain Ca~(2+) and cAMP levels, the analgesic effects by electro-acupuncture, morphine and lanthanides seem to be very similar and share a mutual ion basis and the mechanism of action. So does the development of analgesic tolerance to electro-acupuncture and morphine. These finding 相似文献
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钙离子在电针镇痛、电针耐受和吗啡耐受发展中的作用 总被引:2,自引:0,他引:2
本文研究了Ca~(2+)在电针镇痛、电针耐受和吗啡耐受发展中的作用,同时了解电针耐受发展是否能被蛋白质合成抑制剂抑制。实验结果表明,和吗啡耐受一样,电针耐受动物的脑Ca~(2+)和cAMP水平均明显增高。用蛋白质合成抑制剂茴香霉素(Anisomycin)、放线菌素(Actinomycin)或环己亚胺(Cycloheximide)处理后,电针镇痛耐受发展被抑制,同时使脑Ca~(2+)和cAMP水平降低.从脑Ca~(2+)和cAMP水平的变化看,电针、吗啡和镧系元素引起的镇痛,以及电针和吗啡的耐受发展不仅相似,很可能还有共同的离子基础和作用机理,同时提示蛋白质合成抑制剂阻断电针和吗啡的耐受发展似与新的多肽或RNA合成相关。 相似文献
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脑内有数种内源性吗啡样物质,它们的分布和功能意义不尽相同.为阐明内源性吗啡样物质与针刺镇痛的关系有必要对它们分别进行研究.本文采用灵敏和专一的放射免疫分析法测定了家兔和大白鼠在针麻过程中各脑区及脑脊液中两种脑啡肽的含量变化.主要结果为:(1)针刺镇痛过程中下丘脑及纹状体两种脑啡肽均明显升高;(2)家兔侧脑室注射杆菌肽能够显著增强针效和提高脑内及脑脊液中脑啡肽的含量;(3)蛋白合成抑制剂环己亚胺可以削弱针刺升高脑啡肽含量的作用,说明加速生物合成是针刺增加脑啡肽含量的机制之一;(4)手术游离下丘脑后大白鼠电针效应削弱,提示下丘脑参与了针刺镇痛过程. 相似文献
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α-石英对离体巨噬细胞内游离Ca2+的影响 总被引:3,自引:3,他引:3
本文用荧光试剂Fura-2/AM和AR-CM-MlC阳离子测定系统研究了α-石英对离体肺泡巨噬细胞内游离Ca~(2+)的影响.结果表明:在含Ca~(2+)介质中,α-石英对巨噬细胞的毒性作用引起胞浆游离Ca~(2+)浓度的升高,α-石英剂量越大或作用时间增长,胞浆游离Ca~(2+)浓度升高越大,这种效应只能部分地被Ca~(2+)通道阻断剂异搏定所阻断.但在无Ca~(2+)介质中未观察到细胞胞浆游离Ca~(2+)浓度升高的现象. 相似文献
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