(1R,4S,5S)-6-环己基-4-[(1R,2S,5R)-5-甲基-2-异丙基环己氧基]-3-氧杂-6-氮杂双环[3.1.0]-2-己酮的合成及结构表征

环已胺与差向异构体5-[(1R,2S,5R)-5-甲基-2-异丙基环己氧基]-3-溴-2(5H)-呋喃酮发生不对称Mi-chael加成-分子内亲核取代反应,并经柱层析分离,得到一对手性氮杂环丙烷-丁内酯衍生物,其中的标题化合物为首次得到的新手性化合物,产率17%,其结构经IR、1H NMR、13C NMR和HRMS进行了表征。     

用实体手当作教学模型的尝试

介绍了在有机化学教学实践中总结的用实体手当作教学模型的三方面实例。该方法简便、快捷实用,可以方便学生的学习。     

健康与化学是一门受欢迎的素质教育课

介绍了健康与化学素质教育课的意义、课程的主要教学内容、教学方法和教学实践体会.     

12-磷钨酸及其铯盐的酸位可接近性: 固体核磁共振探针分子研究

 固体酸催化剂的酸位可接近性是影响催化剂性能的重要性质. 使用与反应分子大小接近的碱性探针分子三甲基膦和固体核磁共振技术,定量研究了磷钨酸及其铯盐的酸位可接近性. 结果表明,磷钨酸具有“假液相性”,三甲基膦可以接近磷钨酸体相中的酸位,在无水的磷钨酸中,有大约2/5的酸位可以被三甲基膦所接近. 磷钨酸的铯盐没有“假液相性”,探针分子只能接近催化剂表面的酸位,在无水的Cs1.5H1.5PW12O40中,只有大约5%的酸位能够被三甲基膦所接近.     

席夫碱大环双核锌配合物的合成与表征

本文用丙酮和乙二胺在高氯酸催化下合成了四氮杂十四环席夫碱(1),并用此化合物(1)与氧化锌和叠氮化钠反应,生成锌的双核大环配合物。通过X-射线单晶衍射和红外光谱对其进行了结构表征。该配合物属单斜晶系,C2/c空间群,晶胞参数为a=2.4914(2)nm,b=1.4 9748(13)nm,c=1.26800(11)nm;β=102.1900(10)°;v=4.6240(7)nm3,Z=4,Dc=1.482Mg/m3,Mr=1032.03,F(000)=2160,最终R=0.0506,wR=0.1434。该配合物中锌原子是五配位,它们分别和大环配体上的4个氮原子及叠氮根负离子两端的氮原子配位形成畸变的三角双锥构型。     

Crystal Engineering of Co(Ⅱ) Metal-organic Frameworks Based on the Hydrolysis Product of Letrozole and Coligands

The cyanide groups of letrozole(1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole) were hydrolyzed into the carboxylic groups under alkaline conditions. Then the hydrolysis product(1-[bis(4-carboxylphenyl)methyl]-1,2,4-triazole, H_2ltzda) reacted with Co(NO_3)_2·6H_2O in the presence of different bipyridl-typed ligands under hydrothermal conditions. As a result, two new Co(Ⅱ) MOFs were obtained, formulated as [Co_2(ltzda)_2(bpp)_2]_n(1) and {[Co_2(ltzda)_2(bpy)]·4H_2O}_n(2)(bpp = 1,3-di(4-pyridyl)propane, bpy = 4,4'-bipyridine). Two MOFs have been characterized by single-crystal X-ray diffraction, thermogravimetric analysis and magnetic measure. 1 displays a 2D metal-organic framework containing wave layers and 2 shows a pillared-layer structure existing in a 2-fold interpenetrated mode.     

叠氮桥联四氮杂十四环席夫碱双核铜(Ⅱ)配合物[Cu_2~(2+)(C_(32)H_(64)N_8N_3~-)]_2(ClO_4~-)_6·H_2O的合成与表征

用丙酮和乙二胺在高氯酸催化下合成了四氮杂十四元环席夫碱(1),并用1与碱式碳酸铜和叠氮化钠反应,生成铜的双核大环配合物。通过X-射线单晶衍射和红外光谱对其进行了结构表征。该配合物属单斜晶系,P2(1)空间群,晶胞参数为a=0.93214(8)nm,b=2.03665(17)nm,c=2.6540(2)nm;β=99.6590(10)°;V=4.9670(7)nm3,Z=2,Dc=1.387mg/m3,Mr=2074.76,F(000)=2172,最终R=0.0557,wR=0.1241。该配合物包括2个不对称的双核结构、6个高氯酸根和1个水分子。每一个双核结构中的铜原子都是五配位,它们分别和大环配体上的4个氮原子及叠氮根两端的氮原子配位形成畸变的四方锥构型。     

Formation and Crystal Structure of 1-（N-tert-butyloxycarbonyl-L-prolyl）-1,3-dicyclohexylurea

The title compound 1-(N-tert-butyloxycarbonyl-L-prolyl)-1,3-dicyclohexylurea formed in the coupling reaction of N-Boc-L-proline and n-butyl amine activated by DCC as an unexpected product was characterized through IR,1H NMR,13C NMR and HRMS spectra as well as single-crystal X-ray diffraction analysis.The crystal(C23H39N3O4,Mr = 421.57) belongs to the orthorhombic system,space group P212121,a = 10.8990(5),b = 12.2153(6),c = 18.8102(9) ,V = 2504.3(2) 3,Z = 4,Dc = 1.118 g/cm3,λ(MoKα) = 0.71073 ,μ = 0.076 mm-1,F(000) = 920,the final R = 0.0572 and wR = 0.1521 for 3564 observed reflections with I > 2σ(I).An intramolecular hydrogen bond N(3)-H…O(2) is observed.