A Chinese Lantern-like 2D Cu(Ⅱ) Coordination Polymer Constructed by Bis-imidazole and Dicarboxylate Co-ligands: Synthesis,Crystal Structure and Photocatalytic Activity

A new Cu(II) coordination polymer, {[Cu(1,3-BIP)(TFBDC)]·DMF}n(1,1,3-BIP is a 1,3-bis(imidazole)propane, and H2TFBDC is 2,3,5,6-tetrafluoroterephthalic acid) was prepared under solvothermal conditions and characterized by single-crystal and powder X-ray diffraction, IR spectra, thermogravimetric analyses and elemental analyses. The single-crystal X-ray diffraction reveals that metal coordination polymer 1(MCP 1) shows a two-dimensional sheet layer structure, which is further reinforced through strong intermolecular hydrogen bonding to form a 3 D supramolecular framework. Furthermore, the photocatalytic experiment result indicates the degradation ratios of methyl orange(MO) reach 83.4% within 180 minutes when MCP 1 acts as catalyst.     

新型吡唑甲酰胺类化合物的合成及其抗肿瘤活性

以2-氰基乙酰胺为起始原料,与三乙氧基取代化合物经加成反应制得取代烯酰胺类化合物(3a~3c);3a~3c与芳肼经环合反应得取代吡唑-4-甲酰胺类化合物(5a~5d);5a~5d与酰氯经酰化反应合成了6个新型的1-芳基-3-取代-5-取代氨基-4-吡唑甲酰胺类化合物(7a~7f),其结构经1H NMR,MS和元素分析表征。抗肿瘤活性测试结果表明,7a~7f对人乳腺癌细胞(A)、人宫颈癌细胞(B)和人肝癌细胞(C)有一定抑制作用,其中3-甲基-5-[4-(甲磺酰胺基)苯甲酰胺]-1-苯基-1H-吡唑-4-甲酰胺(7f)的抑制活性最好,对A,B和C的IC50分别为3.25μM,8.74μM和10.47μM。