An Immersed Boundary-Lattice Boltzmann Prediction for Particle Hydrodynamic Focusing in Annular Microchannels

We numerically study the dynamics of particle crystals in annular microchannels by the immersed-boundary(IB)lattice Boltzmann(LB) coupled model, analyze the fluid-particle interactions during the migration of particles,and reveal the underlying mechanism of a particle focusing on the presence of fluid flows. The results show that the Reynolds and Dean numbers are key factors influencing the hydrodynamics of particles. The particles migrate onto their equilibrium tracks by adjusting the Reynolds and Dean numbers. Elliptical tracks of particles during hydrodynamic focusing can be predicted by the IB-LB model. Both the small Dean number and the small particle can lead to a small size of the focusing track. This work would possibly facilitate the utilization of annular microchannel flows to obtain microfluidic flowing crystals for advanced applications in biomedicine and materials synthesis.     

基于UPLC/Q-TOF-MS分析附子半夏配伍相反的物质基础

利用超高效液相色谱-飞行时间质谱联用技术(UPLC/Q-TOF-MS)分析附子半夏药对配伍相反的物质基础,从化学成分层次阐释其配伍相反机制.基于UPLC/Q-TOF-MS建立附子半夏药对配伍后生物碱类成分的化学指纹图谱,通过主成分分析法和正交偏最小二乘判别法分析药对配伍在合煎过程中的生物碱类成分的含量变化,找出差异变化显著的化学成分.结果表明正离子模式时附子半夏药对合煎液中次乌头碱,中乌头碱,乌头碱,去氧乌头碱,10-OH-中乌头碱,10-OH-乌头碱等的含量明显增高,而中乌头原碱,去乙酸中乌头原碱,去乙酸次乌头原碱,苯甲酰乌头原碱,苯甲酰次乌头原碱,10-OH-苯甲酰中乌头原碱等含量降低.附子半夏药对配伍应用时双酯型二萜生物碱的含量明显增高,而单酯型二萜生物碱的含量明显降低,这可能是附子半夏药对配伍相反作用的物质基础.