荧光光谱法研究左氧氟沙星和头孢呋辛与牛血清白蛋白分子的相互作用

在模拟动物生理条件(pH=7.40的Tris-HCl缓冲溶液中)下,左氧氟沙星(LVFX)和头孢呋辛(CEFX)能够猝灭牛血清白蛋白(BSA)的荧光.据此建立了利用荧光光谱法研究抗生素左氧氟沙星(LVFX)和头孢呋辛(CEFX)间相互作用的研究.结果表明:用Stern-Volmer方程处理实验数据发现BSA与药物发生反应生成了新的复合物,猝灭机理以静态猝灭为主,药物与蛋白结合位点数约为1,药物间存在相互作用,使药物与蛋白间的结合常数增大、结合稳定性增大,游离型药物含量减少.     

Collisional Effects on Drift Wave Microturbulence in Tokamak Plasmas

Collisional effects on the microturbulence, excited by the electrostatic drift-wave instability, are investigated through first-principle large scale gyrokinetic particle simulations using the realistic discharge parameters of the DIII–D Tokamak. In the linear simulations, the growth rates of the drift waves are decreased by the collisions compared to the collisionless simulations in the lower and higher T_e plasmas. In the lower T_e plasma, the collisions can promote the transition of the drift wave regime from the TEM-dominant instability to the ITG-dominant instability. The zonal flows are excited by the microturbulence and work as a modulation mechanism for the microturbulence in the nonlinear simulations. Microturbulence can excite high frequency zonal flows in the collisionless plasmas, which is in agreement with the theoretical work. In the lower T_e plasma, the collisions decrease the microturbulence in the nonlinear saturated stage compared to the collisionless simulations, which are beneficial for the plasma confinement. In the higher T_e plasma, the final saturated microturbulence shows a slight change.     

HNO自由基与O2反应机理的理论研究

采用密度泛函理论（DFT）和从头算方法,在B3LYP/6-311++G（d,p）水平上对反应HNO+O₂做了理论计算研究。优化得到了反应物、中间体、过渡态和产物的几何构型以及相应的能量值、振动频率。通过分析反应路径的能量差异,以及异构化难易程度,发现HNO+O₂反应有2种产物通道：HOONO和HNO₃。其中过氧亚硝酸HOONO是主要产物,有3种稳定的构象。     

基于订货满足率的订单装配系统中的库存管理

在本文中,我们研究了订单装配系统的订货满足率问题.在给定库存费用上限的条件下,给出了最优的基本库存水平,并且给出了计算库存水平的方法.     

光谱法研究维生素C和拉米夫定与血清白蛋白的相互作用

应用光谱法研究在模拟动物生理条件（pH=7.40的缓冲溶液）下,维生素C（Vitamin c）和拉米夫定（Lamivudine）对牛血清白蛋白（BSA）的荧光猝灭作用.建立了利用荧光光谱法研究维生素C和拉米夫定间相互作用的方法.用Stern-Volmer方程处理实验数据,发现BSA与药物反应生成新的产物,以静态猝灭为主要猝灭机理,药物与蛋白结合位点数约为1,药物间存在相互作用,增大了药物与蛋白间的结合常数、稳定性,减少了游离型药物含量,造成药效减弱.     

制造商为小本经营情况下的零售商购货机制

研究一个零售商到小本经营的制造商处购货的模型,零售商设计合同最小化自己单位时间的总费用.零售商考虑两个参数:供货时间和进货价格.零售商用最优控制的方法设计进货合同.结果发现β(即制造商承担100β%的制造费用)对于零售商的最优合同有极大的影响.     

乙烯基化的中空二氧化硅球的制备与表征

在乙醇/氨水介质中,以分散法制备的聚苯乙烯微球为模板,通过乙烯基三乙氧基硅烷水解缩合反应在聚苯乙烯表面形成包覆层.然后将聚苯乙烯球核溶解而制备了乙烯基化二氧化硅空心微球.     

信息不对称下制造商填塞分销渠道策略研究

由制造商和零售商构成的二级供应链,制造商管理者可能使用填塞分销渠道策略最大化自己的效用。本文研究在信息不对称的情形下,制造商填塞分销渠道决策对供应链绩效的影响。研究发现:随着修正财务报告的投资者增多,制造商的库存水平以及制造商管理者的效用都会降低;而随着制造商管理者对市场价值重视程度提高,制造商的利润降低,这表明填塞分销渠道对制造商的真实价值产生负面影响。同时,供应链的利润不仅与管理者填塞分销决策有关,还受到零售价格等外在因素的影响。进一步地,加强外部监管以及设计合理的激励制度,有助于减少管理者填塞分销渠道的行为。     

Comparison of ITG and TEM Microturbulence in DⅢ-D Tokamak

Microturbulence excited by ion temperature gradient(ITG)-dominant and trapped electron mode(TEM)-dominant instabilities is compared in the fusion plasmas using gyrokinetic simulations based on the realistic equilibrium data from DⅢ-D discharges.Collisions make a difference between two plasmas and give rise to similar results to those found in previous research experiments[Chin.Phys.Lett.35(2018)105201].The mode structures and frequency spectrum of the most unstable modes characterized by the ITG-dominant and TEM-dominant instabilities are excited in the lower and higher T. plasmas in the linear simulations.In the nonlinear simulations,contour plots of the perturbed potential are shown in the saturated stage,with the radial correlation lengths being microscopic on the order of the ion thermal gyroradius ρi in both the ITG and the TEM microturbulences.The dominant mode wavelengths of the perturbed potential increase when evolving from linear to nonlinear stages in both simulations, with the fluctuation energy spreading from the linearly dominant modes to the nonlinearly dominant modes.The radial correlation lengths are about 4ρi and the electron density fluctuation intensities are about 0.85% in the nonlinear saturated stage,which are in agreement with the experimental results.