Dynamic acceleration effects in explosions of laser-irradiated heteronuclear clusters

Intense, femtosecond irradiation of atomic and molecular clusters can initiate Coulomb explosions, generating particle energies sufficient to drive nuclear fusion. Last and Jortner have proposed, based on particle dynamics simulations, that heteronuclear clusters with a mixture of heavy and light ions will not explode by the simple, equilibrium Coulomb model but that dynamic effects can lead to a boosting of energy of the lighter ejected ions [Phys. Rev. Lett. 87, 033401 (2001)]. We present experimental confirmation of this theoretically predicted ion energy enhancement in methane clusters.     

How Students “Unpack” the Structure of a Word Problem: Graphic Representations and Problem Solving

This research investigated how fourth and fifth grade students spontaneously ‘unpacked’ a word problem when generating a graphic representation to aid in problem solution. Relationships among the type of graphic representation produced, spatial visualization, drawing ability, gender, and problem solving also were examined and described. Instrumentation developed for the study included several math challenge tasks, a spatial visualization task, and a drawing task. For one of the math challenge tasks, students were instructed to draw a picture to assist them with problem solution. These graphic representations generated by students were rated as pictorial or as displaying some level of schematic representation. Schematic representations included germane information from the problem supportive of problem solution. Pictorial representations included expressive and extraneous elements not necessary for problem solution, with no schematic elements. Findings indicated that the majority of students rendered schematic representations, with girls more likely than boys to use schematic representations at a statistically significant level. Students who used schematic visual representations were more successful problem solvers than those pictorially representing problem elements. The more “schematic‐like” the visual representation, the more successful students were at problem solution. Drawing a pictorial representation in the math challenge task also was negatively correlated to drawing skill.     

Redox titration of antioxidant mixtures with N-bromosuccinimide as titrant: analysis by non-linear least-squares with novel weighting function.

Equations are presented by which potential-volume data from redox titrations can be analyzed. Mixtures of analytes as well as of titrants may be analyzed, yielding for each component its concentration, number of electrons, and reduction potential. A novel weighting function ensures endpoint accuracy in fitting. Standard deviation of each parameter is obtained. The equations can be readily implemented in Microsoft Excel. Agreement with true values and good precision of fit parameters is demonstrated for a number of test cases. Use of these exact equations enables analysis of analyte mixtures without prior separation using single titrant or titrant mixtures. The equations were used to demonstrate that N-bromosuccinimide, a useful oxidant for organic analytes, undergoes hydrolysis.     

Production of periodically modulated laser-driven blast waves in a clustering gas

To study hydrodynamic behavior on thin shell high Mach number blast waves, experiments have been performed in which spatially tailored shock waves have been launched in a gas of clusters using an intense 35 fs laser pulse. The target medium was first modified by destroying clusters in specific locations using a spatially modulated laser focus. Under subsequent intense laser irradiation, the efficient absorption properties of the remaining clustered regions compared to those regions with no clusters led to a pattern of hot and cold plasma resulting in a cylindrical blast wave with a periodic modulation imprinted on the shock front. This technique may provide a method for studying thin shell instabilities in strongly radiative blast waves.     

Measurement of the decay rate of single-frequency perturbations on blast waves

To explore the validity of theories forwarded to explain the dynamics of hydrodynamic perturbations on high Mach number blast waves, we have studied the decay rate of perturbations on blast waves traveling through nitrogen gas. In our experiments, 1 kJ pulses from the Z-Beamlet laser at Sandia National Laboratories illuminated solid targets immersed in gas and created blast waves. The polytropic index implied by comparing experiment to theoretical predictions is compared to simulation results.     

Measurements of magneto-Rayleigh-Taylor instability growth during the implosion of initially solid Al tubes driven by the 20-MA, 100-ns Z facility

The first controlled experiments measuring the growth of the magneto-Rayleigh-Taylor instability in fast (～100 ns) Z-pinch plasmas are reported. Sinusoidal perturbations on the surface of an initially solid Al tube (liner) with wavelengths of 25-400 μm were used to seed the instability. Radiographs with 15 μm resolution captured the evolution of the outer liner surface. Comparisons with numerical radiation magnetohydrodynamic simulations show remarkably good agreement down to 50 μm wavelengths.     

Enzyme‐Mediated Modification of Single‐Domain Antibodies for Imaging Modalities with Different Characteristics

Antibodies are currently the fastest‐growing class of therapeutics. Although naked antibodies have proven valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half‐life. They have been conjugated to toxic payloads, PEGs, or radioisotopes to increase and optimize their therapeutic efficacy. Although nonspecific conjugation is suitable for most in vitro applications, it has become evident that site specifically modified antibodies may have advantages for in vivo applications. Herein we describe a novel approach in which the antibody fragment is tagged with two handles: one for the introduction of a fluorophore or ¹⁸F isotope, and the second for further modification of the fragment with a PEG moiety or a second antibody fragment to tune its circulatory half‐life or its avidity. Such constructs, which recognize Class II MHC products and CD11b, showed high avidity and specificity. They were used to image cancers and could detect small tumors.     

Removal of uranium from sulfate leach liquor of salcrete deposits using tri-n-octyl amine

A uranyl sulfate leach liquor obtained by uranium leaching of a technological sample of salcrete deposits of Gabal Qatrani ore was subjected to uranium extraction using the liquid–liquid technique. Uranium was effectively extracted from sulfate leach liquor by [(10 %) tri-n-octylamine (TOA)] dissolved in xylene as a diluent. The extraction efficiency was markedly enhanced as the concentration of TOA increases from 1 to 10 %. The relevant factors controlling the extraction process of uranium using tri-n-octylamine were studied. These factors include the effect of diluents used, TOA concentration, contact time, settling time and phase ratio (O/A) v/v. The optimum extraction conditions were chosen. Stripping of uranium from the loaded TOA has been carried out using 5 % Na₂CO₃ as an effective stripping agent. More than 97 % of uranium was extracted by 10 % TOA, at contact time 10 min, settling time 5 min, phase ratio (V_O/V_A) 1/1 and at room temperature. The feasibility of using the TOA for preconcentration-separation of uranium was assessed by stripping studies. The loaded uranium onto TOA has been stripped by 100 % when using 5 % Na₂CO₃ as an efficient eluting agent at 15 min contact time, 5 min settling time and phase ratio (O/A) 2/1.     

Laboratory simulations of astrophysical blast waves with high energy lasers

We review recent efforts to simulate aspects of supernova remnants in laboratory experiments by creating energetic explosions with high energy lasers. High energy pulsed lasers are uniquely suited for these kinds of studies. By focusing a laser with pulse energy of a few joules to many hundreds of joules onto a solid target or into a dense gas target, explosive shock waves of very high Mach number can be created. With a well chosen set of laser and target parameters it has been shown by a number of groups that radiative blast waves can be produced. Such blast waves have dynamics dominated by radiation transport and exhibit unusual characteristics, the most important of which include hydrodynamic instabilities which may play an important role in the structure of the interstellar medium. As a result there are now prospects for gaining new insights into astronomical observations of supernova remnants by studying laboratory laser driven plasma systems.