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1.
A family of bile acid-based molecular tweezers (1-3) were synthesized, and their binding affinities with picric acid in different solvents were evaluated using a simple extraction-based protocol. The binding affinities increased in nonpolar solvents. The size of the solvent molecule did not affect the binding constant. Thermodynamic parameters for the binding of picric acid in CCl(4) were also determined by this method. Binding constants of these tweezers with trinitrofluorenone in CDCl(3) were determined by NMR titration. 相似文献
2.
A Gurtu P K Malhotra I S Mittra P M Sood SC Gupta VK Gupta GL Kaul LK Mangotra Y Prakash NK Rao ML Sharma 《Pramana》1974,3(5):311-322
This is a continuation of our earlier investigation (Gurtuet al 1974Phys. Lett. 50 B 391) on multiparticle production in proton-nucleus collisions based on an exposure of emulsion stack to 200 GeV/c beam at the NAL. It is found that the ratioR em = 〈n s〉/〈n ch〉, where 〈n ch〉 is the charged particle multiplicity in pp-collisions, increases slowly from about 1 at 10 GeV/c to 1·6 at 68 GeV/c and attains a constant value of 1·71 ± 0·04 in the region 200 to 8000 GeV/c. Furthermore,R em = 1·71 implies an effectiveA-dependence ofR A =A 0.18,i.e., a very weak dependence. Predictions ofR em on various models are discussed and compared with the emulsion data. Data seem to favour models of hadron-nucleon collisions in which production of particles takes place through adouble step mechanism,e.g., diffractive excitation, hydrodynamical and energy flux cascade as opposed to models which envisage instantaneous production. 相似文献
3.
Sciabola S Stanton RV Wittkopp S Wildman S Moshinsky D Potluri S Xi H 《Journal of chemical information and modeling》2008,48(9):1851-1867
Kinases are involved in a variety of diseases such as cancer, diabetes, and arthritis. In recent years, many kinase small molecule inhibitors have been developed as potential disease treatments. Despite the recent advances, selectivity remains one of the most challenging aspects in kinase inhibitor design. To interrogate kinase selectivity, a panel of 45 kinase assays has been developed in-house at Pfizer. Here we present an application of in silico quantitative structure activity relationship (QSAR) models to extract rules from this experimental screening data and make reliable selectivity profile predictions for all compounds enumerated from virtual libraries. We also propose the construction of R-group selectivity profiles by deriving their activity contribution against each kinase using QSAR models. Such selectivity profiles can be used to provide better understanding of subtle structure selectivity relationships during kinase inhibitor design. 相似文献
4.
The eigen frequencies of radial pulsations of neutron stars are calculated in a strong magnetic field. At low densities we
use the magnetic BPS equation of state (EOS) similar to that obtained by Lai and Shapiro while at high densities the EOS obtained
from the relativistic nuclear mean field theory is taken and extended to include strong magnetic field. It is found that magnetized
neutron stars support higher maximum mass whereas the effect of magnetic field on radial stability for observed neutron star
masses is minimal. 相似文献
5.
Munshi G Mustafa Sudhir Raniwala T Awes B Rai RS Bhalerao JG Contreras RV Gavai SK Ghosh P Jaikumar GC Mishra AP Mishra H Mishra B Mohanty J Nayak J-Y Ollitrault SC Phatak L Ramello R Ray PK Sahu AM Srivastava DK Srivastava VK Tiwari 《Pramana》2006,67(5):961-981
This is the report of Heavy Ion Physics and Quark-Gluon Plasma at WHEPP-09 which was part of Working Group-4. Discussion and
work on some aspects of quark-gluon plasma believed to have created in heavy-ion collisions and in early Universe are reported. 相似文献
6.
7.
Ce0.8Eu0.2O2?δ was synthesized by conventional solid state route as well as wet chemical route (i.e. cation complexation, combustion method). The crystallite size obtained for cation complexation and combustion samples is 14 and 19 nm while their surface area is 11.70 and 29.63 m2g?1 respectively. Cation complexation synthesized product lead to formation of agglomerates and hence the sintered sample showed porosity compared to combustion synthesized sample. However, despite high packing density the combustion synthesized sample showed lower grain boundary, total conductivity than cation complexation synthesized product due to the formation of siliceous film at the grain boundary. 相似文献
8.
Two methods are discussed for determining the set of all b for which the system Ax?b (A—constant) is irredundant. For {n=fixed,m=var} and {m-n=fixed,m=var}, the first method is of polynomial complexity and worked significantly faster. The set turns out to be a convex open unbounded polyhedron. 相似文献
9.
Fan X Potluri VK McLeod MC Wang Y Liu J Enick RM Hamilton AD Roberts CB Johnson JK Beckman EJ 《Journal of the American Chemical Society》2005,127(33):11754-11762
Several oxygenated hydrocarbons, including acetylated sugars, poly(propylene glycol), and oligo(vinyl acetate), have been used to generate CO2-soluble ionic surfactants. Surfactants with vinyl acetate tails yielded the most promising results, exhibiting levels of CO2 solubility comparable to those associated with fluorinated ionic surfactants. For example, a sodium sulfate with single, oligomeric vinyl acetate (VAc) tails consisting of 10 VAc repeat units was 7 wt % soluble in CO2 at 25 degrees C and 48 MPa. Upon introduction of water to these systems, only surfactants with the oligomeric vinyl acetate tails exhibited spectroscopic evidence of a polar environment that was capable of solubilizing the methyl orange into the CO2-rich phase. For example, a single-phase solution of CO2, 0.15 wt % sodium bis(vinyl acetate)8 sulfosuccinate, and water, at water loading (W) values ranging from 10 to 40 at 25 degrees C and 34.5 MPa, exhibited a methyl orange peak at 423 nm. This result indicated that the core of a reverse micelle provided a microenvironment with a polarity similar to that of methanol. Quantum chemical calculations indicate that the acetylated sugars may be too hydrophilic to readily form reverse micelles, whereas the VAc-based surfactants appear to have the correct balance of hydrophilic and hydrophobic forces necessary to form reverse micelles. 相似文献
10.
Verma Ashukumar Modi Krunal Dey Shuvankar Kongor Anita Panchal Manthan Vora Manoj Panjwani Falak Jain VK. 《Journal of fluorescence》2022,32(2):637-645
Journal of Fluorescence - Herein, a novel N-(4-(tert-butyl)-phenyl)-2-chloroacetamide functionalized thiacalix[4]arene architecture, viz TCAN2PA has been synthesized and the sensing behaviour... 相似文献