Ferrocenyltrithiocarbonates : I. Direct access from α-ferrocenylcarbinols by a SNi mechanism. Absolute x-ray structure determination of (R)-ferrocenylmethylmethane S-methyl-trithiocarbonate

¹⁰³Rh Chemical shifts of a variety of mono- and di-nuclear rhodium carbonyl complexes are reported together with the modifications to the probe and decoupler unit of a JEOL PS-100 PFT spectrometer which enable these ¹⁰³Rh-decoupled ¹³C NMR measurements to be made. These data are discussed in conjunction with ¹³C NMR data on other rhodium carbonyls.     

Couplage okydatif facile d'anions substitues captodativement

Carbanions carrying captodative substitution are readily oxidized to their dimers.     

Potent Anticancer Efficacy of First-In-Class CuII and AuIII Metaled Phosphorus Dendrons with Distinct Cell Death Pathways

First-in-class Cu^II and Au^III metaled phosphorus dendrons were synthesized and showed significant antiproliferative activity against several aggressive breast cancer cell lines. The data suggest that the cytotoxicity increases with reducing length of the alkyl chains, whereas the replacement of Cu^II with Au^III considerably increases the antiproliferative activity of metaled phosphorus dendrons. Very interestingly, we found that the cell death pathway is related to the nature of the metal complexed by the plain dendrons. Cu^II metaled dendrons showed a potent caspase-independent cell death pathway, whereas Au^III metaled dendrons displayed a caspase-dependent apoptotic pathway. The complexation of plain dendrons with Au^III increased the cellular lethality versus dendrons with Cu^II and promoted the translocation of Bax into the mitochondria and the release of Cytochrome C (Cyto C).     

Stereoselective Cycloaddition of Monosubstituted Ketene to a Methyl Glyoxylate- and Threonine-Derived Imine: Synthesis of Optically Pure β-Lactamic α-Amino Ester with High Functionality

The reaction of chloroacetyl chloride and triethylamine with a chiral imine derived from the combination of methyl glyoxylate and protected L-threonine gave two optically active α-amino acid derivatives with a cis-substituted β-lactam skeleton in a 72:28 ratio. The major product is obtained in 59% yield by simple crystallisation.     

A Convenient Large Scale Synthesis of 1, 1-Diphenyl-1 -silacyclopent-3-ene

An efficient one-step synthesis of 1,1-dipfienyl-1-silacyclopent-3-ene 1 is reported.     

Efficient and Convenient Method for the Synthesis of N‐Arylhydrazones using a Palladium‐Catalyzed Bond‐Forming Reaction

A highly effective, convenient, and reproducible industrial process for palladium‐catalyzed carbon–nitrogen cross coupling has been developed and applied on a large scale. Thus various functionalized N‐arylhydrazones have been easily prepared and well characterized by conventional spectroscopic methods.     

Reduction of nitriles into aldehydes using a TMDS/V(O)(OiPr)3 reducing system

A simple and convenient method for the chemoselective reduction of nitriles into aldehydes using a 1,1,3,3-tetramethyldisiloxane (TMDS)/triisopropoxyvanadium(V) oxide reducing system is described. Aromatic as well as aliphatic nitriles are reduced into the corresponding aldehydes in moderate to good yields.