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Reduction of nitriles into aldehydes using a TMDS/V(O)(OiPr)3 reducing system |
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| Authors: | Stéphane Laval Wissam Dayoub Leyla Pehlivan Estelle Métay Dominique Delbrayelle Gérard Mignani Marc Lemaire |
| Institution: | 1. Laboratoire de Catalyse, Synthèse et Environnement, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), CNRS, UMR 5246, Université Claude-Bernard Lyon 1, campus de la Doua, 43 boulevard du 11 novembre 1918, bât. Curien—CPE, 3e étage, 69622 Villeurbanne, France;2. Minakem SAS, 145 Chemin des Lilas, 59310 Beuvry la Foret, France;3. Rhodia, Lyon Research Center, 85, Avenue des Frères Perret, BP 62, 69192 Saint-Fons Cedex, France |
| Abstract: | A simple and convenient method for the chemoselective reduction of nitriles into aldehydes using a 1,1,3,3-tetramethyldisiloxane (TMDS)/triisopropoxyvanadium(V) oxide reducing system is described. Aromatic as well as aliphatic nitriles are reduced into the corresponding aldehydes in moderate to good yields. |
| Keywords: | Nitriles Aldehydes Reduction 1 1 3 3-Tetramethyldisiloxane (TMDS) Vanadium |
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