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Brahim ABBOU Imane LEBKIRI Hanae OUADDARI Lamya KADIRI Abdelkarim OUASS Amar HABSAOUI Ahmed LEBKIRI El Housseine RIFI 《Turkish Journal of Chemistry》2021,45(2):362
In this work, we study the elimination of three bivalent metal ions (Cd2+, Cu2+, and Pb2+) by adsorption onto natural illitic clay (AM) collected from Marrakech region in Morocco. The characterization of the adsorbent was carried out by X-ray fluorescence, Fourier transform infrared spectroscopy and X-ray diffraction. The influence of physicochemical parameters on the clay adsorption capacity for ions Cd2+, Cu2+, and Pb2+, namely the adsorbent dose, the contact time, the initial pH imposed on the aqueous solution, the initial concentration of the metal solution and the temperature, was studied. The adsorption process is evaluated by different kinetic models such as the pseudo-first-order, pseudo-second-order, and Elovich. The adsorption mechanism was determined by the use of adsorption isotherms such as Langmuir, Freundlich, and Temkin models. Experiments have shown that heavy metals adsorption kinetics onto clay follows the same order, the pseudo-second order. The isotherms of adsorption of metal cations by AM clay are satisfactorily described by the Langmuir model and the maximum adsorption capacities obtained from the natural clay, using the Langmuir isotherm model equation, are 5.25, 13.41, and 15.90 mg/g, respectively for Cd(II), Cu(II), and Pb(II) ions. Adsorption of heavy metals on clay is a spontaneous and endothermic process characterized by a disorder of the medium. The values of ΔH are greater than 40 kJ/mol, which means that the interactions between clay and heavy metals are chemical in nature. 相似文献
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Fertout Radia Imane Ghelamallah Madani Kacimi Soufi López Paloma Navarro Corberán Vicente Cortés 《Russian Journal of Applied Chemistry》2020,93(2):289-298
Russian Journal of Applied Chemistry - Nickel catalysts supported on γ–Al2O3 doped with La2O3 and alkaline earth oxides (MgO, CaO, and SrO) were investigated in the dry reforming of... 相似文献
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Noureddine Bencheikh Mohamed Bouhrim Loubna Kharchoufa Omkulthom Mohamed Al Kamaly Hamza Mechchate Imane Es-safi Ahmed Dahmani Sabir Ouahhoud Soufiane El Assri Bruno Eto Mohamed Bnouham Mohammed Choukri Mostafa Elachouri 《Molecules (Basel, Switzerland)》2021,26(16)
Zizyphus lotus L. (Desf.) (Z. lotus) is a medicinal plant largely distributed all over the Mediterranean basin and is traditionally used by Moroccan people to treat many illnesses, including kidney failure. The nephrotoxicity of gentamicin (GM) has been well documented in humans and animals, although the preventive strategies against it remain to be studied. In this investigation, we explore whether the extract of Zizyphus lotus L. (Desf.) Fruit (ZLF) exhibits a protective effect against renal damage produced by GM. Indeed, twenty-four Wistar rats were separated into four equal groups of six each (♂/♀ = 1). The control group was treated orally with distilled water (10 mL/kg); the GM treated group received distilled water (10 mL/kg) and an intraperitoneal injection of GM (80 mg/kg) 3 h after; and the treated groups received ZLF extract orally at the doses 200 or 400 mg/kg and injected intraperitoneally with the GM. All treatments were given daily for 14 days. At the end of the experiment, the biochemical parameters and the histological observation related the kidney function was explored. ZLF treatment has significantly attenuated the nephrotoxicity induced by the GM. This effect was indicated by its capacity to decrease significantly the serum creatinine, uric acid, urea, alkaline phosphatase, gamma-glutamyl-transpeptidase, albumin, calcium, sodium amounts, water intake, urinary volume, and relative kidney weight. In addition, this effect was also shown by the increase in the creatinine clearance, urinary creatinine, uric acid, and urea levels, weight gain, compared to the rats treated only with the GM. The hemostasis of oxidants/antioxidants has been significantly improved with the treatment of ZLF extract, which was shown by a significant reduction in malondialdehydes levels. Histopathological analysis of renal tissue was correlated with biochemical observation. Chemical analysis by HPLC-DAD showed that the aqueous extract of ZLF is rich in phenolic compounds such as 3-hydroxycinnamic acid, catechin, ferulic acid, gallic acid, hydroxytyrosol, naringenin, p- coumaric Acid, quercetin, rutin, and vanillic acid. In conclusion, ZLF extract improved the nephrotoxicity induced by GM, through the improvement of the biochemical and histological parameters and thus validates its ethnomedicinal use. 相似文献
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Imane Boubezari Ali Zazoua Franois Bessueille Abdelhamid Errachid Nicole Jaffrezic‐Renault 《Electroanalysis》2020,32(7):1642-1650
Instant determination of glucose levels is necessary to monitor the treatment of diabetes. The next generation of electrochemical sensors aims to eliminate the use of enzymes because of their lack of stability and the complex procedure to immobilize them on the electrode. In this paper Pr1.92Ba0.08Ni0.95Zn0.05O4+δ perovskite, a A2BO4+δ type, was tested, for the first time for non enzymatic detection of glucose. It was synthesized by a sol‐gel method. The obtained crystallized powder was structurally characterized by XRD, morphologically characterized by SEM and EDX and electrochemically characterized. A monoclinic crystallographic system was formed. The presence of Pr2O3 during synthesis and calcination is in agreement with the formation of defects in the crystalline network and the disproportionation of NiIII sites into NiII and NiIV, due to the substitution of Pr by Ba. The oxido‐reduction of NiII sites is observed by cyclic voltammetry. The electrocatalytic oxidation of glucose through the electrooxidized NiII site was observed on a gold electrode, at 481 mV. The analytical performance of this glucose sensor is good in comparison to previously published ABO3 perovskite modified electrodes, in terms of dynamic range (1.5 μM–7000 μM) and detection limit (0.5 μM). Its application to human serum shows that there is no interference for glucose detection. 相似文献
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James D. Grayson Matthew P. Baumgartner Cleide Dos Santos Souza Samuel J. Dawes Imane Ghafir El Idrissi Jennifer C. Louth Sasha Stimpson Emma Mead Charlotte Dunbar Joanna Wolak Gary Sharman David Evans Anastasia Zhuravleva Margarita Segovia Roldan Nicola Antonio Colabufo Ke Ning Claire Garwood James A. Thomas Benjamin M. Partridge Antonio de la Vega de Leon Valerie J. Gillet Amlia P. Rauter Beining Chen 《Chemical science》2021,12(10):3768
Amyloid β oligomers (Aβo) are the main toxic species in Alzheimer''s disease, which have been targeted for single drug treatment with very little success. In this work we report a new approach for identifying functional Aβo binding compounds. A tailored library of 971 fluorine containing compounds was selected by a computational method, developed to generate molecular diversity. These compounds were screened for Aβo binding by a combined 19F and STD NMR technique. Six hits were evaluated in three parallel biochemical and functional assays. Two compounds disrupted Aβo binding to its receptor PrPC in HEK293 cells. They reduced the pFyn levels triggered by Aβo treatment in neuroprogenitor cells derived from human induced pluripotent stem cells (hiPSC). Inhibitory effects on pTau production in cortical neurons derived from hiPSC were also observed. These drug-like compounds connect three of the pillars in Alzheimer''s disease pathology, i.e. prion, Aβ and Tau, affecting three different pathways through specific binding to Aβo and are, indeed, promising candidates for further development.A new approach combining virtual screening, 19F and STD NMR, and biochemical assays using hiPSC and targetting multiple pathways involving Aβ, PrPC and Tau provides a more effective strategy for Alzheimer''s disease drug discovery than Aβ only approach. 相似文献
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Imane Es-safi Hamza Mechchate Amal Amaghnouje Omkulthom Mohamed Al Kamaly Fatima Zahra Jawhari Hamada Imtara Andriy Grafov Dalila Bousta 《Molecules (Basel, Switzerland)》2021,26(7)
Depression and anxiety are major mental health problems in all parts of the world. These illnesses are associated with a number of risk factors, including oxidative stress. Psychotropic drugs of a chemical nature have demonstrated several side effects that elevated the impact of those illnesses. Faced with this situation, natural products appear to be a promising alternative. The aim of this study was to evaluate the anxiolytic and antidepressant effects of the Petroselinum sativum polyphenols in vivo, as well as its correlated antioxidant properties in vitro. Anxiolytic activity of the extract (50 and 100 mg/kg) was evaluated using the open field and the light-dark chamber tests, while the antidepressant activity was evaluated using the forced swimming test. The antioxidant activity of the extract was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical test and the FRAP (iron-reducing capacity) test. The phenolic extract showed very powerful anxiolytic and antidepressant-like effects, especially at a dose of 100 mg/kg, decreasing the depressive behavior in mice (decreased immobility time) and also the anxiolytic behavior (tendency for discovery in the center and illuminated areas) better even than those of paroxetine and bromazepam (classic drugs) concomitant with those results the extract also showed an important antioxidant capacity. These preliminary results suggest that Petroselinum sativum exhibits anxiolytic and antidepressant potential for use as a complement or independent phytomedicine to treat depression and anxiety. 相似文献
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Khadija El Ouahdani Imane Es-safi Hamza Mechchate Mohammed Al-zahrani Ashraf Ahmed Qurtam Mohammed Aleissa Amina Bari Dalila Bousta 《Molecules (Basel, Switzerland)》2021,26(22)
The study of bioactive molecules of natural origin is a focus of current research. Thymus algeriensis and Artemisia herba-alba are two medicinal plants widely used by the Moroccan population in the traditional treatment of several pathologies linked to inflammation. This study aimed to evaluate the single and combined antioxidant, anti-inflammatory and analgesic effects of the essential oils extracted from these two medicinal plants, and also their potential toxicity. Essential oils were extracted using hydro-distillation in a Clevenger-type apparatus. The antioxidant activity was evaluated by two methods: the scavenging of the free radical DPPH, and the reduction in iron. Anti-inflammatory activity was evaluated by evaluating the edema development induced by carrageenan injecting, while the analgesic power was evaluated according to the number of abdominal contortions induced by the intraperitoneal injection of acetic acid (0.7%). The acute oral toxicity was performed to assess the potential toxicity of the studied EOs, followed by an analysis of the blood biochemical parameters. The results of the two antioxidant tests indicated that our extract mixture exhibits good iron reduction capacity and very interesting DPPH free radical scavenging power, with an IC50 of around 4.38 ± 0.98 μg/mL higher than that of the benchmark antioxidant, BHT. The anti-inflammatory test demonstrated that the mixture administered orally at a dose of 150 mg/kg has a better activity, exceeding that of 1% Diclofenac, with a percentage of maximum inhibition of the edema of 89.99 ± 4.08. The number of cramps in the mice treated with the mixture at a dose of 150 mg/kg is significantly lower (29.80 ± 1.92) than those of the group treated with Tramadol (42.00 ± 2.70), respectively. The toxicity results show no signs of toxicity with an LD50 greater than 150 mg/Kg. These interesting results show that the two plants’ EOs had an important anti-inflammatory, analgesic, and antioxidant activity, and also a powerful synergistic effect, which encourages further in-depth investigations on their pharmacological proprieties. 相似文献