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1.
H. Enginar P. Ünak F. Yurt F. Zümrüt Biber 《Journal of Radioanalytical and Nuclear Chemistry》2002,251(3):473-479
An oestrogen derivative 3,17-a-oestradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid)ester (ESTCPTA) that is 3,17-a-oestradiolyl propinol coupled to 1-(4-methylbenzoic acid)1,4,8,11-tetraazacyclotetradecane (CPTA) was synthesized in five steps. The product was purified by recrystallization in ethyl alcohol, and analysed by NMR and IR spectroscopy. ESTCPTA was labeled with 99mTc and radio thin layer chromatography (RTLC) and radio-paper electrophoresis were used to determine the radiochemical yields. Specific activity was approximately 23.7 GBq/mmol and the labeling yield was over 95%. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacricified by ether narcotization at certain time intervals and the activity of the organs was counted by a gamma counter. The activity per gram tissue was calculated and time activity curves were generated. 相似文献
2.
H. Ozakay P. Ünak Z. Biber F. Yurt 《Journal of Radioanalytical and Nuclear Chemistry》1998,230(1-2):231-233
The most suitable way of determination iodine-deficiency is to measure iodine concentrations in water and urine. For this reason, a method that can determine iodide concentrations in drinking water and suitable for routine analysis, is developed. Water samples have been collected from four Aegean localities: Izmir, Salihli, Ödemis and Tire situated in the western Turkey. The method is based on substochiometric isotope dilution analysis. Iodile concentrations vary within 9.86–85.14 μg/l ranges in the analyzed samples. Mean value is 44.92±22.07 μg/l. 相似文献
3.
Burak Sabuncu Fazilet Zumrut Biber Muftuler Ayfer Yurt Kilcar Betul Cekic Eser Ucar Perihan Unak 《Journal of Radioanalytical and Nuclear Chemistry》2014,300(3):1021-1026
People drink various types of tea without knowing the side effects of biological and chemical contents and radiopharmaceutical interactions. In current study, it is aimed to evaluate the effects of green tea extract in different extraction solvents on the radiolabeling of the blood constituents with 99mTc and on the biodistribution of radiopharmaceutical sodium pertechnetate (Na99mTcO4) in male Wistar Albino rats. The extraction of green tea was performed in different solvents. Biodistribution studies were performed on male rats which were treated via gavage with green tea extract in different extraction solvents or saline (0.9 % NaCl) as a control group for 7 days. The radiolabeling of blood constituents performed incubating with SnCl2 and 99mTc. According to experimental results, radiolabeling blood components with 99mTc were not modified in the usage of the different extraction solvents for green tea extraction, but a significant alteration (P < 0.05) of biodistribution of Na99mTcO4 was observed after treatment with green tea extract in distilled water. Although there is no considerable effect on radiolabeling of blood components, there is an outstanding change on the biodistribution studies especially with green tea extract in distilled water. The identified change monitored in this study may cause to reduce the risk of misdiagnosis and/or avoid the repetition of the examinations in nuclear medicine. 相似文献
4.
Ayfer Yurt Kilcar Fazilet Zumrut Biber Muftuler Huseyin Enginar Volkan Tekin Emin Ilker Medine Perihan Unak 《Journal of Radioanalytical and Nuclear Chemistry》2014,302(1):563-573
Recently, the development of novel brain imaging agents has aroused much interest thanks to limited number of brain cancer or diseases diagnosis agents. It is aimed to synthesize a novel brain imaging agent including a promise for further studies on AD diagnosis potential and investigate its bioaffinity with biodistribution studies on healthy Balb/c mice. A novel radiolabeled agent was synthesized and characterized. Quality control of 99mTc-BH was performed utilizing solvent extraction and chromatographic (Radio TLC and Radio HPLC) methods. Bioaffinity of the 99mTc-BH was investigated on male Balb/c mice at various time points (5, 30, 60, 120 min post-injection). Paper electrophoresis showed that 99mTc-BH has a neutral structure. Radiochemical purity of 99mTc-BH was over 95 % with appropriate stability for imaging period. Selected brain regions have uptakes over 4 % ID/g following intravenous injection. Hippocampus has uptake approximately 10 % ID/g. 99mTc-BH has shown brain uptake, so it may prove to be valuable for brain imaging as a novel technetium-labeled agent. Further investigations with AD animal model are our on going effort to show that this agent has AD diagnosis potential. 相似文献
5.
Avcıbaşı Uğur Türkyarar Taner Karadağ Ayşegül Bakan Buket Yavaşoğlu Nefise Ülkü Karabay Kuşat Kevser Akgöl Sinan Gülcemal Derya Tekin Volkan Müftüler Fazilet Zümrüt Biber Topal Gökcen Parlak Yasemin Gümüşer Fikriye Gül 《Journal of Radioanalytical and Nuclear Chemistry》2021,329(2):511-525
Journal of Radioanalytical and Nuclear Chemistry - The aim of this study is the synthesis of a novel 99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties.... 相似文献
6.
A. Biber A. Golick M. Tomak 《International Journal of Infrared and Millimeter Waves》2002,23(9):1315-1325
This paper presents the analytical proof of Time-Domain Mapping Method for the spherical resonator made up of uniaxial crystal. In this way, the main types of caustics inside the spherical resonator made up of uniaxial crystal, which were investigated numerically before, are confirmed analytically. It is engraved that the problem of the ray flow inside the spherical resonator can be reduced to the problem of the ray flow inside metal cavity shaped as spheroid. 相似文献
7.
C. Acar S. Teksöz P. Ünak F. Z. Biber 《Journal of Radioanalytical and Nuclear Chemistry》2007,273(3):641-647
Somatostatin inhibits the release of growth hormone (somatotropin) from the Anterior Pituitary. The main use of derivatives
of somatostatin is to diagnose growth hormone problems and to use against some forms of cancer which involve growth hormone.
Also somatostatin suppresses gastric acid secretion, gallbladder contractions, and pancreatic enzyme secretion. The aim of
the current study is to investigate new bifunctional agents for labeling with 99mTc. Therefore D-Penicillamine was used as a bifunctional agent and compared to DTPA in the labeling with 99mTc. Quality controls were established using thin layer radio chromatography (TLRC) and electrophoresis techniques. In addition,
high performance liquid radio chromatography (HPLRC) was also performed for elimination of possible uncertainties. The radiolabeled
complexes maintained their stabilities throughout the study. The results obtained showed that 99mTc-D-Penicillamine-somatostatin is a promising potential radiopharm aceutical and an alternative of 99mTc-DTPA-somatostatin for in vivo and in vitro applications. 相似文献
8.
Esra Korkmaz Kirakli Gökhan Takan Sinan Hoca F. Zümrüt Biber Müftüler Ayfer Yurt Kılçar Serra Arun Kamer 《Journal of Radioanalytical and Nuclear Chemistry》2018,315(3):595-602
The purpose of this study was to assess SPION’s in vitro radiosensitizer effect at 6MV-energies and to calculate nanoparticle enhancement ratio (NER) of SPIONs. Citrate coated-SPION’s were synthesized. Trypan-blue, metabolic activity tests were performed. Cell cultures were irradiated at 0,2,4,6,8 Gy at 6MV-energy. Clonogenic survival assays, NER calculations were carried out. SPIONs were biocompatible. NERs were cell-line specific and dose dependent. The highest radiosensitization were seen in radiosensitive MCF-7 and MDAH-2447 cells at 2 Gy (NER:1.49 and 1.39 respectively), in relatively radioresistant MDA-MB-231 cells at 4 Gy (NER:1.20). By increasing doses radiosensitizer effect disappeared. There is possibility that by synergistic effect, SPIONs may cause dose-dependent and cell-line specific radiosensitization at 6MV. 相似文献
9.
C. Acar S. Teksoz P. ünak F. Z. Biber Müftüler E. I. Medine 《Journal of Radioanalytical and Nuclear Chemistry》2009,280(2):375-380
The aim of this study is to investigate stereoisomeric behavior of penicillamine and the effect of temperature on labeling.
In addition, it was explored how stereoisomerism affected biological behavior of them. In the present work, D- and L-enantiomers
of penicillamine(D-PA, L-PA) were labeled with 99mTc using SnCl2 as reducing agent and their radiopharmaceutical potentials were investigated. Quality control procedures were carried out
using thin layer radiochromatography (TLRC), electrophoresis and high performance liquid radiochromatography (HPLRC). HPRLC
chromatograms showed two peaks for 99mTc-D-PA, while a single peak was observed for 99mTc-L-PA at room temperature. However, the single peak was observed at 90 °C for both isomers. Labeling yields of each isomer
were found to be over 98%. Biological activity of these complexes was determined on male Albino Wistar rats by biodistribution
studies. While the biodistribution result of 99mTc-D-PA showed high uptake in the liver, maximum uptake of 99mTc-L-PA was observed in the kidneys. Both two complexes were cleared rapidly from the blood, mainly by the renal system. Since
the activity concentration of 99mTc-D-PA at the 30th minute in the kidneys and the liver reached a maximum value and at the 120th minute, it was removed by
renal and hepatobiliary excretion. As a result, it can be concluded that stereoisomerism affect not only the chemical behavior,
but also differs their biological behavior of these compounds. 相似文献
10.
Cansu Uzaras Uğur Avcıbaşı Hasan Demiroğlu Emin İlker Medine Ayfer Yurt Kılçar Fazilet Zümrüt Biber Müftüler Perihan Ünak 《Journal of Radioanalytical and Nuclear Chemistry》2016,307(1):131-140
The aim of this study is to determine the incorporations of PHT radiolabeled with 131I (131I-PHT) on U-87 MG, Daoy and A549 cancerous cell lines. For this, cold and radio-labeling studies were carried out. The radio-labeling yield of 131I-PHT was obtained about 95 %. Subsequently, cell culture studies were carried out and radio-labeling yields of 131I, 131I-PHT on U-87 MG, Daoy and A549 cancerous cells were investigated. Cell culture studies demonstrated that the incorporation values of 131I-PHT on the three cell lines decreased with increasing radioactivity. Consequently, 131I-PHT may be a good radiopharmaceutical for targeting radionuclide therapy of Central Nervous System Tumors. 相似文献