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In this study, multiwalled carbon nanotubes (MWCNTs) were used to encapsulate a model anticancer drug, doxorubicin (Dox). Then, the drug-loaded MWCNTs (Dox/MWCNTs) with an optimized drug encapsulation percentage were mixed with poly(lactide-co-glycolide) (PLGA) polymer solution for subsequent electrospinning to form drug-loaded composite nanofibrous mats. The structure, morphology, and mechanical properties of the formed electrospun Dox/PLGA, MWCNTs/PLGA, and Dox/MWCNTs/PLGA composite nanofibrous mats were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and tensile testing. In vitro viability assay and SEM morphology observation of mouse fibroblast cells cultured onto the MWCNTs/PLGA fibrous scaffolds demonstrate that the developed MWCNTs/PLGA composite nanofibers are cytocompatible. The incorporation of Dox-loaded MWCNTs within the PLGA nanofibers is able to improve the mechanical durability and maintain the three-dimensional structure of the nanofibrous mats. More importantly, our results indicate that this double-container drug delivery system (both PLGA polymer and MWCNTs are drug carriers) is beneficial to avoid the burst release of the drug and able to release the antitumor drug Dox in a sustained manner for 42 days. The developed composite electrospun nanofibrous drug delivery system may be used as therapeutic scaffold materials for post-operative local chemotherapy. 相似文献
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荧光探针法研究胶原蛋白的水溶液聚集状态 总被引:14,自引:0,他引:14
利用一种分子内电荷转移化合物3 甲氧基 4’ N,N 二甲氨基黄酮(DMMF)作为荧光探针,研究了胶原蛋白在水溶液中的聚集状态.研究结果发现,当胶原蛋白浓度增大到05mg/mL以上时,DMMF在465nm处的荧光强度有一突跃;继续增大其浓度,荧光强度越来越大.证明胶原蛋白在水溶液中随浓度增大有明显的聚集行为.利用荧光偏振法测量该体系内DMMF的荧光偏振特性,发现当胶原蛋白浓度增大到05mg/mL以上时,体系具有较高的微粘度,进一步证实了胶原蛋白在水溶液中的聚集特性. 相似文献
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N—异丙基丙烯酰胺/丙烯酸十八酯共聚物水溶液胶束及相分?… 总被引:5,自引:2,他引:3
合成了N-异丙基丙烯酰胺(NIPAM)和丙烯酸十八酯(ODA)的共聚物,利用荧光探针和滴重法研究了NIPAM-烘聚物在水溶液中的胶束形成过程,同时还利用荧光探针法研究了共聚物水溶液在温度升高时出现的LCST现象,表明该高分子在温度升高时存在着相分离现象,利用L-B技术测量共聚物不溶单分子膜的π-A曲线,发现随着温度升高共聚物的单分子膜越来越凝聚的反常现象,这从另一个侧面证实了共聚物NIPAMODA 相似文献
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Formation of multifunctional Fe_3O_4/Au composite nanoparticles for dual-mode MR/CT imaging applications 下载免费PDF全文
Recent advances with iron oxide/gold(Fe3O4/Au) composite nanoparticles(CNPs) in dual-modality magnetic resonance(MR) and computed tomography(CT) imaging applications are reviewed. The synthesis and assembly of "dumbbelllike" and "core/shell" Fe3O4/Au CNPs is introduced. Potential applications of some developed Fe3O4/Au CNPs as contrast agents for dual-mode MR/CT imaging applications are described in detail. 相似文献
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Capture and detection of metastatic cancer cells are crucial for diagnosis and treatment of malignant neoplasm. Here, we report the use of folic acid (FA) modified electrospun poly(vinyl alcohol) (PVA)/polyethyleneimine (PEI) nanofibers for cancer cell capture applications. Electrospun PVA/PEI nanofibers crosslinked by glutaraldehyde vapor were modified with FA via a poly(ethylene glycol) (PEG) spacer, followed by acetylation of the fiber surface PEI amines. The formed FA-modified nanofibers were well characterized. The morphology of the electrospun PVA/PEI nanofibers is smooth and uniform despite the surface modification. In addition, the FA-modified nanofibers display good hemocompatibility as confirmed by hemolysis assay. Importantly, the developed FA-modified nanofibers are able to specifically capture cancer cells overexpressing FA receptors, which were validated by quantitative cell counting assay and qualitative confocal microscopy analysis. The developed FA-modified PVA/PEI nanofibers may be used for capturing circulating tumor cells for cancer diagnosis applications. 相似文献
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脂质体是一种内层含有水相的、封闭的圆球状双层膜结构体系,作为药物释放系统具有独特的优点:既可以在其内水相包封水溶性药物,也可以在外层双层膜内包封脂溶性药物,它和天然生物膜的生物相容性比较好,在药物学研究应用中安全可靠。 相似文献
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作者以氨基封端的第五代聚酰胺胺(PAMAM)树状大分子为模板,借助静电相互作用将氯金酸盐吸引进入树状大分子内部,再由外加还原剂硼氢化钠将金盐原位还原,得到了树状大分子包裹的金纳米颗粒(Dendrimer-Entrapped Gold Nanoparticles,Au DENPs),并应用紫外、表面电势法、透射电镜和能量色散谱等手段对其结构进行表征。通过改变氯金酸与树状大分子的投料比,平均尺寸在1.9~2.8nm的Au DENPs被成功制备。制得的Au DENPs不仅在水、PBS缓冲液以及生理环境下稳定存在,还在较宽的pH(pH=5~8)与温度(4~50℃)范围内稳定,为其应用于生物医学领域提供了可能。 相似文献
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树状大分子是一类高度支化的单分散性大分子,具有精确可控的分子结构.本文在树状大分子结构特点的基础上,阐述了以树状大分子为载体的新型纳米CT成像造影剂的合成及其在CT成像中的应用,并对树状大分子在CT成像中的发展趋势和应用领域进行了展望. 相似文献
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N-异丙基丙烯酰胺/丙烯酸十八酯共聚物水溶液胶束及相分离行为研究 总被引:3,自引:0,他引:3
合成了N异丙基丙烯酰胺(NIPAM)和丙烯酸十八酯(ODA)的共聚物.利用荧光探针和滴重法研究了NIPAMODA共聚物在水溶液中的胶束形成过程.同时还利用荧光探针法研究了共聚物水溶液在温度升高时出现的LCST(LowerCriticalSolutionTemperature)现象,表明该高分子在温度升高时存在着相分离现象.利用LB技术测量共聚物不溶单分子膜的PA曲线,发现随着温度升高共聚物的单分子膜越来越凝聚的反常现象,这从另一个侧面证实了共聚物NIPAMODA的相分离行为,并对此现象作了讨论. 相似文献