Synthesis, Crystal Structure and Antiproliferative Activity of 2,2-Dimethyl-4-oxochroman-3-ylmorpholine-4-carbodithioate

The crystal structure of the new title compound 2,2-dimethyl-4-oxochroman-3-ylmorpholine-4-carbodithioate(C16H19NO3S2,Mr = 337.44) has been prepared and determined by single-crystal X-ray diffraction.The crystal is of triclinic,space group P1 with a = 9.5518(7),b = 9.7172(7),c = 11.0220(8),α = 67.08(1),β = 74.66(1),= 61.31(1)°,V = 822.72(10)3,Z = 2,Dc = 1.362 g/cm3,F(000) = 356,μ = 0.092 mm-1,MoKa radiation(λ = 0.71073),R = 0.0515 and wR = 0.1389 for 2623 observed reflections with I > 2(I).X-ray diffraction analysis reveals that the chroman ring adopts a half-chair conformation while the morpholine ring shows a chair conformation.Intramolecular and intermolecular C-H···S and C-H···O hydrogen bonds together with π-π interations are found in the structure.The result of MTT assay shows the title compound displays good antiproliferative activity against two human cancer cell lines.     

Synthesis and X-ray Crystal Structure of a Methylene-bridged Glycoluril Dimer

The synthesis and X-ray crystal structure of a methylene-bridged glycoluril dimer 2 was reported.The methylene-bridged glycoluril dimer 2(C38H36Br4N8O12,Mr=1116.35) crystallizes in space group P1 with a=10.5802(6),b=16.8469(9),c=24.7673(14) ,α=98.00,β=96.263(1),γ=101.606(1)o,V=4239.3(4)3,Z=4,Dc=1.749 g/cm3,μ=3.869 mm-1 and F(000)=2224.It crystallizes in an S-shaped conformation that displays two ethoxycarbonyl groups on each face of the molecule.     

类杯芳烃合成受体的拓扑选择性合成

具有高度识别性的新型合成受体的构筑一直是主客体化学的研究热点[1],因为它们是人们借以模拟生物酶的复杂结合过程、了解酶与底物之间弱相互作用力(如疏水效应、π-π堆积、氢键等)的作用形态的桥梁分子[2,3].目前,对一些经典的受体,如环糊精、杯芳烃、葫芦脲等,都已进行过广泛而深入的研究,但由于这些受体的孔径较小,构造板块单一,从而限制了它们对客体分子识别的选择性和包结能力.我们在考虑和设计新的分子受体的结构时,期望以多样性的构造板块构造出拥有较大三维几何空腔的分子,从而提高受体的选择性和识别能力.     

天然产物吴茱萸碱一锅法合成的综合实验设计

结合天然产物全合成的理论知识,设计了从简单易得的底物出发实现吴茱萸碱一锅法合成的综合化学实验。实验过程包括背景文献调研与分析总结、吴茱萸碱一锅法合成、化合物波谱性质表征以及反应机理研究。该综合实验不仅可以培养学生的文献检索、合成操作以及谱图分析等方面的综合能力,而且可以提高学生对有机合成方法学及反应机理研究的理解,提升学生对科学研究逻辑的认知,为将来从事相关科研或实践工作打下基础。     

Synthesis,Crystal Structure and Biological Activity of 8-（（4-（（2,3-diaminopyridin-4-yl）oxy）-3-fluorophenyl）-amino）-2-（4-fluorophenyl）-3-methyl-2,7-naphthyridin-1（2H）-one

The new title compound 8-((4-((2,3-diaminopyridin-4-yl)-oxy)-3-fluorophenyl)-amino)-2-(4-fluorophenyl)-3-methyl-2,7-naphthyridin-1(2H)-one(C26H20F2N6O2, Mr = 486.48) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/c with a = 15.365(3), b = 13.144(2), c = 11.863(2), β= 108.882(3)°, Z = 4, V = 2267.0(7)3, Dc = 1.425 g/cm3, F(000) = 1008, μ = 0.105 mm-1, MoKa radiation(λ = 0.71073), R = 0.0480 and wR = 0.1294 for 3197 observed reflections with I 2σ(I). X-ray diffraction analysis reveals that the region C(substituents of 8-amino group and 3-methyl group on the 2,7-naphthyridin-1(2H)-one ring) of compound 6 are effectively planar. Intramolecular and intermolecular hydrogen bonds together with π···π interations are found in the structure. In addition, compound 6 shows potent c-Met and c-Kit kinase inhibition activities.     

师范院校有机化学教学融入课程思政的探索与实践*

通过有机化学的教学探索与实践,着力构建三维课程思政建设体系,让“课程思政”进课前、驻课中、留课后,挖掘有机化学思政元素、构建课程思政案例库,并在探索与实践中实施教学效果调查、跟踪学生发展、深化反思总结,努力发挥有机化学教学融入课程思政的积极成效,实现通过有机化学专业课程的教与学来达到育人目的,助力培养卓越未来教师。     

BOPPPS教学模式的教学设计要素分析及案例设计*

BOPPPS教学模式与课堂的5W教学要素有紧密的联系,它强调以学生为中心,将课堂6个教学模块进行分解。研究探讨了BOPPPS教学模式的教学设计要素涵义及应用策略,结合有机化学课程的双分子亲核取代机理教学设计及其教学效果,说明该模式的具体实施之策。     

二元组装体集群时的高选择性杂化重组行为

多样性自组装体在混合时,通常表现出互不干扰的自分类性,能高度选择性地自分类堆积.但结构极为相似的组装子在相互混合时,会发生交互作用并表现出重组现象.文中合成和观测了具有芳香环边墙和不同酰胺侧链的C型甘脲分子夹为组装单元的混合组装行为.研究发现,此类分子在各自以单一态物质溶解于CDCl3时,能通过π-π相互作用和氢键形成二聚自组装体;若将两种具有不同酰胺侧链的C型甘脲分子夹两两混合,从理论上推测应有三种二聚自组装堆积态存在：A·A、B·B、A·B.但经1HNMR分析发现了一个有趣的现象,即当酰胺侧链上的取代基R′分别为具有C-H结构（如1和2）与PhF5基（5）的组装体两两混合时,二聚组装主要呈现出高度选择性杂化重组的A·B结构态.这种取代基控制的高选择性重组行为可能是基于π-π相互作用、N—H…O氢键,以及C—H…π等三重作用力的协同结果.