排序方式: 共有18条查询结果,搜索用时 62 毫秒
1.
M.M. Elseweidy N.N. Younis S.E. Elswefy F.R. Abdallah S.I. El-Dahmy G. Elnagar 《Natural product research》2015,29(10):961-965
The anti-atherogenic potentials of total ginger (Zingiber officinale) extract (TGE) or curcuminoids extracted from turmeric (Curcuma longa), members of family Zingiberaceae, were compared in hypercholesterolaemia. Rabbits were fed either normal or atherogenic diet. The rabbits on atherogenic diet received treatments with TGE or curcumenoids and placebo concurrently for 6 weeks (n = 6). The anti-atherogenic effects of curcuminoids and ginger are mediated via multiple mechanisms. This effect was correlated with their ability to lower cholesteryl ester transfer protein activity. Ginger extract exerted preferential effects on plasma lipids, reverse cholesterol transport, cholesterol synthesis and inflammatory status. Curcuminoids, however, showed superior antioxidant activity. 相似文献
2.
合成了3种含姜黄素衍生物(L1~L3)和1,3,5-三氮杂-7-磷金刚烷(PTA)配体的芳基钌配合物[(η6-p-cymene)Ru(L)(PTA)]PF6(1~3,L=L1~L3),通过X射线单晶衍射、核磁共振波谱、高分辨质谱、元素分析等方法表征了这些配合物的结构,并用MTT法研究了它们在λ>400 nm的光照辅助下对Hep G2人肝癌细胞的增殖抑制活性。结果表明,这3个配合物均为半三明治型结构;光辅助下,配合物抗癌活性明显提高,其中配合物3对HepG2细胞的IC50值从(60.3±1.1)μmol·L-1降低至(45.0±6.1)μmol·L-1。说明光照可以有效提高此类配合物的抗肿瘤活性。 相似文献
3.
《应用有机金属化学》2017,31(9)
A series of curcuminoids (L1–L7) and their corresponding (η6‐p ‐cymene)RuII(Cur)Cl complexes ( 1 – 7 ) were synthesized and characterized using 1H NMR spectroscopy, elemental analysis and high‐resolution electrospray ionization mass spectrometry. The molecular structures of L2, L4, 1 and 4 were determined using single‐crystal X‐ray diffraction analysis. The stability of 1 – 7 was investigated by monitoring their UV profiles. The compounds were further evaluated for their in vitro antiproliferative activities against the HepG2 human liver and HeLa human cervical cancer cell lines and HEK‐293 T noncancerous cell line. 相似文献
4.
Rois Benassi Erika Ferrari Sandra Lazzari Francesca Pignedoli Ferdinando Spagnolo Monica Saladini 《Journal of Physical Organic Chemistry》2011,24(4):299-310
In the present study, we investigate the structures of glucosylated curcumin derivatives with DFT at B3LYP/6‐31G* level. A conformational analysis is performed in order to determine the conformational minimum (GS) and rotational transition state (TS) of curcumin derivatives and then their electronic features are evaluated. HOMO and LUMO frontier orbitals and maps of electron density potential (MEPs) are plotted and compared. In order to correlate their predicted spectroscopic properties with IR, UV–vis and NMR experimental data we extended the theoretical study on electronic properties to different solvents (H2O, MeOH, ACN, DMSO). The main finding is that the curcuminic core maintains the same geometrical and electronic structures in all compounds miming the metal coordination capability showed by curcumin. Therefore, we may confirm that the presence of glucose does not affect the electronic properties of the derivatives. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
5.
Epi Erpina Latifah Kosim Darusman Arum Vitasari Budi Riza Putra Eti Rohaeti 《液相色谱法及相关技术杂志》2017,40(12):635-639
A new method for simultaneous quantification of curcuminoids and xanthorrhizol (XNT) in Curcuma xanthorrhiza was developed and validated using high-performance liquid chromatography with diode-array UV–Vis detector. The chromatographic separation was achieved on a Phenomenex C18 at room temperature with the mobile-phase acetonitrile ?0.001% formic acid in gradient elution system and delivered at a flow rate of 1?mL/min. Detection wavelength 425?nm was used for curcuminoids and 224?nm for XNT. System suitability, linearity, precision, accuracy, limit of detection, limit of quantitation, and stability were evaluated and were found in good agreement with Association of Official Analytical Chemists guidelines for single-laboratory validation. The proposed method was found to be precise, accurate, and reliable and also could be applied for the simultaneous quantitative analysis of curcuminoids and XNT in C. xanthorriza raw material and its herbal medicinal product. 相似文献
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7.
Lajos Szente Katsuhiko Mikuni Hitoshi Hashimoto József Szejtli 《Journal of inclusion phenomena and macrocyclic chemistry》1998,32(1):81-89
The paper provides data on the practical utilization of the benefits of the molecular encapsulation of natural colorants by cyclodextrins. Experimental results on the stability of cyclodextrin complexed curcumin, curcuma oleoresin, -carotene and carotenoid oleoresins against light-, heat- and oxygen prove the benefits of molecular encapsulation of colorants. The parent -cyclodextrin stabilized most effectively the curcumines, while the stability of carotenoids was most effectively achieved by -cyclodextrin complexation. Methylated -cyclodextrin was found to be the most potent solubilizing agent for both carotenoids and curcuminoids. 相似文献
8.
高效液相色谱法检测食品中姜黄素类化合物 总被引:1,自引:0,他引:1
建立了食品中姜黄素类化合物的液相色谱分析方法。采用甲醇提取试样中姜黄素及其同系物去甲氧基姜黄素和双去甲氧基姜黄素,以YMCTMCarotenoid色谱柱(250 mm×4.6 mm,5μm)分离,甲醇水溶液(A)-甲基叔丁基醚(B)梯度洗脱。对所分析化合物的稳定性、前处理条件及色谱条件进行考察。3种分析物在0.5~100μg/mL范围内线性关系良好,相关系数为0.997 7~0.999 8。在10~100 mg/kg加标浓度范围内,平均回收率为72.2%~102%,相对标准偏差为3.4%~13.8%。对姜黄素、去甲氧基姜黄素和双去甲氧基姜黄素的检出限分别为6、5、5 mg/kg。方法稳定、可靠,已应用于实际样品的检测。 相似文献
9.
T. V. Deepthi 《Journal of Coordination Chemistry》2016,69(22):3403-3416
Copper(II) chelates of three unsymmetrical synthetic analogs of curcumin, namely (2E)-2-(4-hydroxy-3-methoxybenzylidene)-5-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)cyclopentanone(1), (2E)-2-(3,4-dihydroxybenzylidene)-5-((E)-3-(3,4-dihydroxyphenyl)acryloyl)cyclopentanone(2), and (2E)-2-(3,4-dimethoxybenzylidene)-5-((E)-3-(3,4-dimethoxyphenyl)acryloyl)cyclopeantanone(3) have been synthesized and characterized by physicochemical and spectroscopic methods. The ligands were in their enolic form and metal complexes have 1 : 2 metal:ligand stoichiometry. The DNA-binding properties of the ligands and their metal complexes were studied by absorption titrations, fluorescence quenching experiments, and viscosity measurements with calf-thymus DNA. The interactions of copper(II) complexes were higher than that of free ligands. The observed intrinsic binding constants reveal moderate interaction of copper(II) complexes with calf-thymus DNA. The binding involves intercalative mode through non-covalent interactions and produced conformational changes in the structure of DNA. The compounds were investigated for their possible cytotoxic and antitumor activities. All the compounds were cytotoxic towards Dalton’s lymphoma ascites cells. It was found that copper chelates are remarkably active compared to free curcumin analogs. Concentrations needed for 50% cell death were 10–22 μg mL?1 for copper complexes and 27–52 μg mL?1 for curcumin analogs. Copper complex of 2 with two hydroxyl groups in the phenyl ring was most active towards Dalton’s lymphoma ascites cells (increase in life span 77.91%). Copper(II) complex of 3, which possesses methoxy groups in the phenyl ring system, showed the lowest activity towards increase in lifespan of tumor-bearing mice (increase in lifespan 60.14%). Copper chelates of all curcuminoid analogs showed a significant reduction in solid tumor volume in mice. 相似文献
10.
合成了3种含姜黄素衍生物(L1~L3)和1,3,5-三氮杂-7-磷金刚烷(PTA)配体的芳基钌配合物[(η6-p-cymene)Ru(L)(PTA)]PF6(1~3,L=L1~L3),通过X射线单晶衍射、核磁共振波谱、高分辨质谱、元素分析等方法表征了这些配合物的结构,并用MTT法研究了它们在λ>400 nm的光照辅助下对HepG2人肝癌细胞的增殖抑制活性。结果表明,这3个配合物均为半三明治型结构;光辅助下,配合物抗癌活性明显提高,其中配合物3对HepG2细胞的IC50值从(60.3±1.1)μmol·L-1降低至(45.0±6.1)μmol·L-1。说明光照可以有效提高此类配合物的抗肿瘤活性。 相似文献