一种新的腺苷酸人工受体

报道由刚性双环胍桥联胸腺嘧啶碱基和亲脂性(特丁基二苯基)硅醚基的腺苷酸受体的合成。液液萃取和1^HNMR实验表明该受体能通过互补氢键和静电引力与腺苷酸钠盐,尤其是与3'-腺苷酸二钠盐互相识别形成脂溶性的超分子配合物,因而能把水溶性的腺苷酸盐从水相转移到机相。     

Interaction and Interfacial Molecular Recognition of Calix[4] arene Derivatives Bearing Nucleobases for Complementary Nucleoside

The p-tert-butyl calix[4] arene derivatives la with uracils and 1b with adenines at the lower rim were synthesized.The Interaction between 1a and 1b in CDCl3 solution was demonstrated by ^1H NMR spectra.The interfacial molecular recognitions of la and 1b for the complementary nucleosides in aqueous subphases were investigated by Langmuir-Blodgett technique.     

手性环胍衍生物的合成

以L-天冬酰胺为原料经十步反应合成了光学纯的手性双环胍, 总收率为2.2%. 这一合成方法的优点是避免使用剧毒的硫光气和气味难闻的有机硫化物