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N-烷基-1,10-菲咯啉2-甲胺La(Ⅲ)配合物的合成及抗癌活性 总被引:4,自引:0,他引:4
合成和表征了甲基、乙基、丙基、丁基和苄基N-取代1,10-菲咯啉2-甲胺衍生配体及其镧(Ⅲ)配合物. 研究了配合物对HL60人白血病、PC-3MIE8人前列腺癌、BGC-823人胃癌、MDA-MB-435人乳腺癌、Bel-7402人肝癌、Hela人宫颈癌共6种瘤株的体外抗肿瘤活性及其与DNA的作用方式. 结果表明, 该系列化合物对实验的6种瘤株均具有不同程度的生长抑制作用, 其中配合物L5LaL5对MDA-MB-435人乳腺癌和Bel-7402人肝癌的抑制效果较好, 对Bel-7402人肝癌和Hela人宫颈癌的抑制效果优于顺铂. 其作用机理可能是配合物以部分插入方式同时伴随共价和静电与DNA发生作用, 影响其基因调控与表达, 进而抑制肿瘤细胞的生长, 最终导致癌细胞凋亡. 相似文献
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水平变化环境下声场简正波解的计算精度和效率取决于本地简正波的计算方法。提出一种完备的一阶微扰理论方法,并引入迭代算法,获得了本地简正波水平波数和本征函数的精确表达式。数值结果表明,改进后的微扰简正波方法得到的简正波水平波数和本征函数精度比前人方法更高,与KRAKENC计算结果吻合较好,而计算速度比KRAKENC快100倍。同时将微扰简正波方法与耦合简正波理论结合,应用到海水声速水平变化剧烈的孤立子内波群环境。数值结果表明,该方法计算得到的传播损失与COUPLE07在单次散射近似下的计算结果吻合较好,计算速度比COUPLE07快25倍,并将该方法在声场计算中的适用频率提高到了3 kHz。 相似文献
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基于非线性动力学对海洋混响建模,提出了一种自适应非线性预测方法,通过设计一个滤波器来逼近混响信号在相空间的演化轨迹;采用在不同海域进行的两次海上实验获取的混响信号,对自适应预测方法进行验证,其单步预测结果与实验信号符合较好;以模型的单步预测误差作为检验统计量来检测混响中的目标回波,可以在一定程度上抑制混响干扰,提高信混比. 相似文献
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取犬血浆500μL,加入20.0μg·L~(-1)氯霉素内标甲醇溶液50μL,用甲基叔丁基醚(MTBE)先后萃取2次,使样品中雌三醇(E_3)溶入MTBE中,MTBE的加入量均为1.00mL,充分摇匀2.0min后,离心10min。收集并合并2次萃取的上清液,氮吹至干。加入甲醇100μL溶解残渣后再次离心10min,取上清液(10.0μL)进样进行色谱分离。用Agilent XDB-C18色谱柱为固定相,和以不同比例的乙腈(A)和水(B)的混合液作流动相进行梯度洗脱。串联质谱分析中采用电喷雾离子源负离子扫描和多反应监测模式。测得E_3的线性范围在0.2~40.0μg·L~(-1)之间,测定下限(10S/N)为0.2μg·L~(-1)。在空白犬血浆中加入E_3标准溶液进行回收率和精密度试验,测得日间回收率在93.3%~110%之间,测定值的日内和日间相对标准偏差(n=5)分别在1.6%~3.1%和4.2%~5.9%之间。 相似文献
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We propose a geoacoustic inversion scheme employing a vector hydrophone array based on the fact that vector hydrophone can provide more acoustic field information than traditional pressure hydrophones. Firstly, the transmission loss of particle velocities is discussed. Secondly, the sediment sound speed is acquired by a matchedfield processing (MFP) procedure, which is the optimization in combination of the pressure field and vertical particle velocity field. Finally, the bottom attenuation is estimated from the transmission loss difference between the vertical particle velocity and the pressure. The inversion method based on the vector hydrophone array mainly has two advantages: One is that the MFP method based on vector field can decrease the uncertain estimation of the sediment sound speed. The other is that the objective function based on the transmission loss difference has good sensitivity to the sediment attenuation and the inverted sediment attenuation is independent of source level. The validity of the inverted parameters is examined by comparison of the numerical results with the experimental data. 相似文献
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A novel ligand N-ethyl-1,10-phenanthroline-2-methanamine and its Ni(Ⅱ) complex have been synthesized. The crystal structure of the complex has been determined by X-ray diffraction method. The Ni(Ⅱ) is five-coordinated by three nitrogen atoms from the ligand and two Cl- anions in a distorted trigonal bipyramidal environment: the N(2), Cl(1) and Cl(2) in equatorial plane; the N(1) and N(3) in axial positions. The UV-spectra and IR-spectra of the ligand and its Ni(Ⅱ) complex were recorded and discussed. The thermodynamic properties of the ligand with various bivalent metals were studied by potentiometric titrations and the order of the stability constants is in agreement with the Irving-Williams order in coordination chemistry. CCDC: 221750. 相似文献