开发中国营养平衡米提高老人健康水平

介绍了广州老人进食中国营养平衡米(下称平衡米)的效果.营养调查发现,180例广州老人Ca、P、Fe、Zn和Se摄入量分别为403、807、17、14 mg和46 μg,说明老人Ca、Zn、Se不足.原因是主食籼米矿物质营养不平衡.建议进食营养平衡米后,老人Ca、P、Fe、Zn 和 Se 摄入量分别提高到1 153、863、45、45 mg和111 μg,结果表明,进食平衡米可以提高广州老人矿物质营养水平,致使老人健康长寿.对此,建议开发和推广食用中国营养平衡米.     

广州老人钙及磷,铁,锌,硒营养状况的研究

通过称量法，记帐法和询问法对广州市三所老人院１８０名老人进行了营养调查，并分析了钙，磷，铁，锌，硒的营养状况，结果表明，每人每日营养元素摄入量为钙４０３ｍｇ，磷８０７ｍｇ，铁１７ｍｇ，锌１４ｍｇ硒４６μｇ据此认为，广州老人缺钙，锌，硒。原因是饮食习惯不良，主食钙，锌，硒量低及食谱不合理，建议对老人改革主食结构，进食营养平衡米，制定合理的食谱，增加户外活动，多晒太阳，进行钙，锌，硒补充。     

均衡膳食可使幼儿锌、铜、铁营养平衡研究

目的通过幼儿进食均衡膳食可使锌、铜、铁营养平衡,目的使幼儿健康成长。方法常规体检、原子吸收法血检3 000多幼儿,其中随机抽查300名幼儿作调查,进行均衡膳食前后的自身对比。结果幼儿进食均衡膳食后,每人每日锌、铜、铁摄入量达标,则血中锌、铜、铁含量达标;而进食均衡膳食前每人每日锌、铜、铁摄入量不达标,导致血中锌、铜、铁含量也不达标,则会影响幼儿生长发育和健康成长。结论建议在幼儿及学生中推广均衡膳食和开展营养工程,以保证其健康成长。     

Expanding Horizons of Metal Oxide-based Chemical and Electrochemical Sensors

Metal-oxide (MOx) are widely used in electrical/electrochemical sensors owing to their quick-response ability, High surface-to-volume ratio, matching lateral-dimensions with surface-charge zone and modifiable with dopants significantly enhances their sensing performance. Typically, MOx-based sensors are used in gaseous-analytes for monitoring environmental-pollutants and gas-leakage. Tuning the properties of nanostructured-metal-oxides advanced their applications beyond environmental-monitoring. This review focuses on the emerging-dimensions of MOx-based sensors in hazard-surveillance and risk-investigation like in deployment to detect fire-hazards, chemical-warfare agents, oil-spills and explosives. Recent advances of using MOx-based sensors as electronic-tongue and electronic-nose for non-invasive health monitoring and MOx-based sensor mobile robots for remote surveillance is also discussed.     

基于地理因素的健康中青年(18～40)PaO_2参考值预测研究

动脉血氧分压(PaO_2)参考值是医学诊治的重要指标,并随地理因素的变化而变化.鉴于各地参考值的不同,从地理因素角度出发,利用各地的各项地理因素指标,与各地的健康中青年动脉血氧分压参考值建立相关分析和回归分析,以此建立较为精确的预测模型,用以验证已知地区和预测未知地区的参考值.其建立的预测模型为医学参考值的制定提供了新的方法,并促进了地理资源的实践发展.     

Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study

A rapid, sensitive and specific method to quantify cyproheptadine in human plasma using amitriptyline as the internal standard (IS) is described. The analyte and the IS were extracted from plasma by liquid‐liquid extraction using a diethyl‐ether/dichloromethane (70/30; v/v) solvent. After removing and drying the organic phase, the extracts were reconstituted with a fixed volume of acetonitrile/water (50/50 v/v) + 0.1% of acetic acid. The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry (LC‐MS/MS). Chromatography was performed isocratically using an Alltech Prevail C18 5 µm analytical column, (150 mm x 4.6 mm I.D.). The method had a chromatographic run time of 4 min and a linear calibration curve ranging from 0.05 to 10 ng/mL (r2 > 0.99). The limit of quantification was 0.05 ng/mL. This HPLC/MS/MS procedure was used to assess the bioequivalence of cyproheptadine in two cyproheptadine + cobamamide (4 mg + 1 mg) tablet formulations (Cobactin® [cyproheptadine + cobamamide] test formulation supplied from Zambon Laboratórios Farmacêuticos Ltda. and Cobavital® from Solvay Farma (standard reference formulation)). A single 4 mg + 1 mg [cyproheptadine + cobamamide] dose of each formulation was administered to healthy volunteers. The study was conducted using an open, randomized, two‐period crossover design with a 1‐week washout interval. Since the 90% CI for Cmax and AUCs ratios were all within the 80‐125% bioequivalence limit proposed by the US Food and Drug Administration, it was concluded that the cyproheptadine test formulation (Cobactin®) is bioequivalent to the Cobavital® formulation for both the rate and the extent of absorption of cyproheptadine. Copyright © 2011 John Wiley & Sons, Ltd.     

减肥产品中非法添加西布曲明类似物的ESI-MS/MS检测与确证

通过分析西布曲明和减肥类健康产品中未知化合物质谱图的质谱信息,由高分辨串联质谱获得裂解碎片离子的精密质量数,质谱软件给出碎片的可能组成,推测了西布曲明和未知化合物的质谱裂解途径,进而推测出该化合物的结构。并通过合成该结构的化合物,采用液相色谱-串联质谱法对样品作确证检验,证实样品中添加了新的西布曲明类似物。该实验提供了一种可用于检测和确证健康产品中非法添加合成药物未知类似物的方法。     

Pharmacokinetic profile of ivabradine hemisulfate sustained‐release tablets administered in Chinese healthy volunteers: An open‐label,randomized, single‐dose,three‐period crossover study

We aimed to determine the pharmacokinetics and safety of three single oral doses (5, 10 and 15 mg) of ivabradine hemisulfate sustained‐release tablets in healthy Chinese volunteers. A total of 12 volunteers (six males and six females) were randomized to receive a single oral dose of ivabradine hemisulfate sustained‐release tablets 5, 10 or 15 mg, with a 1‐week washout between periods. Blood samples were collected at regular intervals from 0 to 48 h after drug administration, and the concentrations of ivabradine and N‐desmethyl ivabradine were determined by HPLC–tandem mass spectrometry. Pharmacokinetic parameters were estimated by non‐compartmental analysis. After administering single doses of 5, 10 and 15 mg, the mean maximum concentration (C_max) levels of ivabradine were 4.36, 7.29 and 12.62 ng/mL, and the mean area under the curve from time 0 to 48 h (AUC_0–48) values were 55.66, 101.16 and 182.09 h·ng/mL, respectively. The mean C_max levels of N‐desmethyl ivabradine were 1.05, 2.03 and 3.16 ng/mL, and the mean AUC_0–48 values were 20.61, 39.44 and 65.72 h·ng/mL, respectively. The median time of maximum concentration (T_max) levels of ivabradine and N‐desmethyl ivabradine were 5 h for all three doses tested. The pharmacokinetic properties of ivabradine hemisulfate sustained‐release tablets were linear at doses from 5 to 15 mg. Ivabradine hemisulfate sustained‐release tablet appears to be well tolerated in these healthy volunteers.     

Lupin Protein Isolate Structure Diversity in Frozen-Cast Foams: Effects of Transglutaminases and Edible Fats

This study addresses an innovative approach to generate aerated foods with appealing texture through the utilization of lupin protein isolate (LPI) in combination with edible fats. We show the impact of transglutaminases (TGs; SB6 and commercial), glycerol (Gly), soy lecithin (Lec) and linoleic acid (LA) on the micro- and nanostructure of health promoting solid foods created from LPI and fats blends. 3-D tomographic images of LPI with TG revealed that SB6 contributed to an exceptional bubble spatial organization. The inclusion of Gly and Lec decreased protein polymerization and also induced the formation of a porous layered material. LA promoted protein polymerization and formation of homogeneous thick layers in the LPI matrix. Thus, the LPI is a promising protein resource which when in blend with additives is able to create diverse food structures. Much focus has been placed on the great foamability of LPI and here we show the resulting microstructure of LPI foams, and how these were improved with addition of TGs. New food applications for LPI can arise with the addition of food grade dispersant Lec and essential fatty-acid LA, by improved puffiness, and their contributing as replacer of chemical leavening additives in gluten-free products.     

人口迁入与新增确诊数的趋势关系及因果量化分析

目前,很多地区新冠肺炎疫情已得到缓解,复工、复产已被多地政府部门提上日程.2月10日前后,全国各地返城复工人数增多,2月14日开始,广东、河南等地新增病例数出现了明显反弹,人口跨地区迁徙使疫情防控更加困难.目前全国返工、返校需求还远未得到满足,需要通过数据分析,对"返城复工"的风险进行评估.通过观察数据可以发现人口迁徙与新增确诊病例数有很强的正相关性,因此由"格兰杰因果检验"确定了人口迁徙与新增确诊病例数有显著的因果关系.