Macrocybin,a Natural Mushroom Triglyceride,Reduces Tumor Growth In Vitro and In Vivo through Caveolin-Mediated Interference with the Actin Cytoskeleton

Mushrooms have been used for millennia as cancer remedies. Our goal was to screen several mushroom species from the rainforests of Costa Rica, looking for new antitumor molecules. Mushroom extracts were screened using two human cell lines: A549 (lung adenocarcinoma) and NL20 (immortalized normal lung epithelium). Extracts able to kill tumor cells while preserving non-tumor cells were considered “anticancer”. The mushroom with better properties was Macrocybe titans. Positive extracts were fractionated further and tested for biological activity on the cell lines. The chemical structure of the active compound was partially elucidated through nuclear magnetic resonance, mass spectrometry, and other ancillary techniques. Chemical analysis showed that the active molecule was a triglyceride containing oleic acid, palmitic acid, and a more complex fatty acid with two double bonds. The synthesis of all possible triglycerides and biological testing identified the natural compound, which was named Macrocybin. A xenograft study showed that Macrocybin significantly reduces A549 tumor growth. In addition, Macrocybin treatment resulted in the upregulation of Caveolin-1 expression and the disassembly of the actin cytoskeleton in tumor cells (but not in normal cells). In conclusion, we have shown that Macrocybin constitutes a new biologically active compound that may be taken into consideration for cancer treatment.     

Properties of mono-weakly hyponormal 2-variable weighted shifts

In this paper, we study several properties for mono-weakly hyponormal 2-variable weighted shifts. First, we consider propagation phenomena for mono-weakly hyponormal (resp. mono-polynomially hyponormal) 2-variable weighted shifts. Next, we contemplate the mono-weak hyponormality under the Schur product. Finally, we study whether the mono-weak hyponormality is invariant under powers.     

On warped product manifolds satisfying some curvature conditions

We determine curvature properties of pseudosymmetric type of certain warped product manifolds, and in particular of generalized Robertson–Walker spacetimes, with Einsteinian or quasi-Einsteinian fibre.     

Four-mode coherent-entangled state and its application

A new kind of four-mode continuous variable coherent-entangled state is proposed in the Fock space by using the technique of integration within an ordered product,which exhibits both the properties of a coherent state and an entangled state,and spans a complete and orthonormal representation.The conjugate state of the four-mode continuous variable coherent-entangled state is derived by using the Fourier transformation.Moreover,a simple experimental protocol of generating a four-mode continuous variable coherent-entangled state is proposed by using beam splitters.As applications of this four-mode continuous variable coherent-entangled state,a four-mode entangled state and a four-mode squeezing-Fresnel operator are constructed.     

On the Development of Titanium κ1-Amidinate Complexes,Commercialized as Keltan ACE™ Technology,Enabling the Production of an Unprecedented Large Variety of EPDM Polymer Structures

ARLANXEO Elastomers has developed and commercialized Keltan ACE™ technology, a class of half-sandwich cyclopentadienyl κ¹-amidinate metal complexes, which are extremely active for the production of first-class ethylene/propylene/diene copolymers (EPDM). In this review, the development and some of the key features of the Keltan ACE™ catalyst system are presented. Many different ACE catalysts have been synthesized over the past years, including bridged and bimetallic catalysts. With Keltan ACE™, a complete range of EPDM products with similar polymer characteristics as their Ziegler–Natta (ZN) counterparts can be produced, including variations containing very high 5-ethylidene-2-norbornene (ENB) contents, controlled long chain branching, very high molecular weight, as well as oil-extended products. Moreover, other EPDM structures can be polymerized. The Keltan ACE™ catalyst technology also allows the production of EPDMs with very high amounts of dicyclopentadiene (DCPD) or 5-vinyl 2-norbornene (VNB) without excessive gelation and reactor fouling, that is, products that cannot or are extremely difficult to obtain via classical ZN catalysis. In a next step, high-VNB-EPDM can be postreactor modified, for example, via metathesis chemistry. In addition, EPDM polymers with a very broad or even bimodal molecular weight distribution can be obtained in a single reactor with certain ACE catalyst structures at particular activator/precatalyst ratios. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55, 2877–2891     

Ap和Hp空间的乘子

给出了关于Ａ^p和Ｈ^p空间系数乘子的一些结果     

Testifying experiment of the multi-pulse phenomena of capillary discharge soft-X-ray laser

In a capillary discharge experiment for the neon-like argon lasing, we have proposed an experimental scheme to verify that the multi-spike of X-ray diode (XRD) signal is a multi-pulse laser or is a reflection of the laser pulse in the XRD.The ceramic capillary has an inner diameter of 3mm and a length of 200mm.At the gas pressure of 28Pa and discharge current of 27kA, stable lasing has been realized.The experimental results prove that the multi-spike of XRD signal is a reflection of the electromagnetic signal produced by the laser pulse in the XRD.The improved electrocircuit scheme of the XRD to minimize the reflection phenomena is also found.     

Decompositions of Fundamental Groups of Closed Surfaces into Free Constructions

Let T be a closed surface. It is proven that any decomposition of ₁(T,x) into an amalgamated product (or, more generally, into the fundamental group of a finite graph of groups) with f.g. edge group(s) is almost geometric. A problem of H. Zieschang is solved and the edge rigidity property is investigated.     

An Inequality for Tail Probabilities of Martingales with Bounded Differences

Let M _n =X₁+...+X_n be a martingale with bounded differences X_m=M_m-M_m-1 such that {|X_m| _m}=1 with some nonnegative _m. Write ²= ₁ ² + ... + _n ² . We prove the inequalities {M _nx}c(1-(x/)), {M _n x} 1- c(1- (-x/)) with a constant . The result yields sharp inequalities in some models related to the measure concentration phenomena.     

Natural bound in Kwiecinski's criterion for flatness

Kwiecinski has proved a geometric criterion for flatness: A morphism of germs of analytic spaces is not flat if and only if its fibre power has a vertical component, for some . We show how to bound using Hironaka's local flattener: If is not flat, then has a vertical component, where is the minimal number of generators of the ideal in of the flattener of .