Effects-based chemical category approach for prioritization of low affinity estrogenic chemicals

Regulatory agencies are charged with addressing the endocrine disrupting potential of large numbers of chemicals for which there is often little or no data on which to make decisions. Prioritizing the chemicals of greatest concern for further screening for potential hazard to humans and wildlife is an initial step in the process. This paper presents the collection of in vitro data using assays optimized to detect low affinity estrogen receptor (ER) binding chemicals and the use of that data to build effects-based chemical categories following QSAR approaches and principles pioneered by Gilman Veith and colleagues for application to environmental regulatory challenges. Effects-based chemical categories were built using these QSAR principles focused on the types of chemicals in the specific regulatory domain of concern, i.e. non-steroidal industrial chemicals, and based upon a mechanistic hypothesis of how these non-steroidal chemicals of seemingly dissimilar structure to 17ß-estradiol (E2) could interact with the ER via two distinct binding types. Chemicals were also tested to solubility thereby minimizing false negatives and providing confidence in determination of chemicals as inactive. The high-quality data collected in this manner were used to build an ER expert system for chemical prioritization described in a companion article in this journal.     

Relative derived equivalences and relative homological dimensions

Let A be a small abelian category. For a closed subbifunctor F of Ext_A¹(-,-), Buan has generalized the construction of Verdier's quotient category to get a relative derived category, where he localized with respect to F-acyclic complexes. In this paper, the homological properties of relative derived categories are discussed, and the relation with derived categories is given. For Artin algebras, using relative derived categories, we give a relative version on derived equivalences induced by F-tilting complexes. We discuss the relationships between relative homological dimensions and relative derived equivalences.     

On the predictability of discrete dynamical systems III

Given an integer n?2, a metrizable compact topological n-manifold X with boundary and a finite positive Borel measure μ on X, we prove that “most” homeomorphisms are non-sensitive μ-almost everywhere on X. Moreover, we also prove that for “most” homeomorphisms the non-wandering set Ωf has μ-measure zero.     

The Change-Base Issue for Ω-Categories

Let G ： Ω→Ω＇ be a closed unital map between commutative, unital quantales. G induces a functor G^- from the category of Ω-categories to that of Ω＇-categories. This paper is concerned with some basic properties of G^-. The main results are： （1） when Ω, Ω＇ are integral, G ： Ω→Ω＇ and F ： Ω＇→Ω are closed unital maps, F is a left adjoint of G^- if and only if F is a left adjoint of G; （2） G^- is an equivalence of categories if and only if G is an isomorphism in the category of commutative unital quantales and closed unital maps; and （3） a sufficient condition is obtained for G^- to preserve completeness in the sense that GA is a complete Ω＇-category whenever A is a complete Ω-category.     

关于(f,τ) -相容Hopf代数对(B,H)

该文定义了(f,τ) -相容Hopf代数对(B,H),利用这样的对(B,H),给出了左H -余模范畴^HM的一个辫子张量子范畴,从而得到一个量子Yang-Baxter算子,并且通过扭曲Hopf代数$B$的乘法,构造出Yetter-Drinfeld范畴中^H_HYD的Hopf代数.     

Maximal exact structures on additive categories revisited

Sieg and Wegner showed that the stable exact sequences define a maximal exact structure (in the sense of Quillen) in any pre‐abelian category 1 . We generalize this result to weakly idempotent complete additive categories.     

关于余极限范畴(英文)

本文研究了余极限范畴.利用余完备Abel范畴的定义,证明了余完备Abel范畴A的余极限范畴Acl是余完备的Abel范畴,并得到一类等价于模范畴的余极限范畴,从而推广了文献[9]中的一些结果.     

Finitary-Algebraic ‘Resolution’ of the Inner Schwarzschild Singularity

A ‘resolution’ of the interior singularity of the spherically symmetric Schwarzschild solution of the Einstein equations for the gravitational field of a point-particle is carried out entirely and solely by finitistic and algebraic means. To this end, the background differential spacetime manifold and, in extenso, Differential Calculus-free purely algebraic (:sheaf-theoretic) conceptual and technical machinery of Abstract Differential Geometry (ADG) is employed. As in previous works [Mallios, A. and Raptis, I. (2001). Finitary spacetime sheaves of quantum causal sets: Curving quantum causality. International Journal of Theoretical Physics, 40, 1885 [gr-qc/0102097]; Mallios, A. and Raptis, I. (2002). Finitary Čech-de Rham cohomology. International Journal of Theoretical Physics, 41, 1857 [gr-qc/0110033]; Mallios, A. and Raptis, I. (2003). Finitary, causal and quantal vacuum Einstein gravity. International Journal of Theoretical Physics 42, 1479 [gr-qc/0209048]], which this paper continues, the starting point for the present application of ADG is Sorkin's finitary (:locally finite) poset (:partially ordered set) substitutes of continuous manifolds in their Gel'fand-dual picture in terms of discrete differential incidence algebras and the finitary spacetime sheaves thereof. It is shown that the Einstein equations hold not only at the finitary poset level of ‘discrete events,’ but also at a suitable ‘classical spacetime continuum limit’ of the said finitary sheaves and the associated differential triads that they define ADG-theoretically. The upshot of this is two-fold: On the one hand, the field equations are seen to hold when only finitely many events or ‘degrees of freedom’ of the gravitational field are involved, so that no infinity or uncontrollable divergence of the latter arises at all in our inherently finitistic-algebraic scenario. On the other hand, the law of gravity—still modelled in ADG by a differential equation proper—does not break down in any (differential geometric) sense in the vicinity of the locus of the point-mass as it is traditionally maintained in the usual manifold-based analysis of spacetime singularities in General Relativity (GR). At the end, some brief remarks are made on the potential import of ADG-theoretic ideas in developing a genuinely background-independent Quantum Gravity (QG). A brief comparison between the ‘resolution’ proposed here and a recent resolution of the inner Schwarzschild singularity by Loop QG means concludes the paper. PACS numbers: 04.60.−m, 04.20.Gz, 04.20.−q     

The braid index is not additive for the connected sum of 2-knots

Any -dimensional knot can be presented in a braid form, and its braid index, , is defined. For the connected sum of -knots and , it is easily seen that holds. Birman and Menasco proved that the braid index (minus one) is additive for the connected sum of -dimensional knots; the equality holds for -knots. We prove that the equality does not hold for -knots unless or is a trivial -knot. We also prove that the -knot obtained from a granny knot by Artin's spinning is of braid index , and there are infinitely many -knots of braid index .

     

单纯广群的准层和同伦纤维

显示了在设置C上的单纯广群的准层的范畴是个封闭模型范畴.证明了在一个单纯广群的准层G上的单纯函子X是局部弱等价于同伦纤维.