Spectrophotometric determination of some antipsychotic phenothiazines

Thioridazine hydrochloride reacts with sodium nitrite and antimony(III) potassium tartrate in the presence of hydrogen peroxide to give a yellowish orange colour having maximum absorbance at 420 nm. The reaction is specific for antipsychotic phenothiazines with 1 g/ml as visual limit of identification and provides a basis for a new Spectrophotometric determination. The colour reaction obeys Beer's Law from 0.01 to 1.25 mg/10ml thioridazine. The standard deviation does not exceed 0.050 mg/10 ml. The method is successfully applied to pure and pharmaceutical preparations of antipsychotic phenothiazines, as well as to urine samples. The quantitative assessment of tolerable amounts of other drugs is also studied.     

盐酸二乙胺与己二酸、癸二酸的相关系

在电子工业中,盐酸二乙胺常与己二酸或癸二酸等二羧酸配合用作有机软钎剂的活性成份[1].文献中极少报道有关有机物的相图研究[2],上述(C2H5)2NH·HCl-C6H10O4和(C2H5)2NH·HCl-C10H18O4的相图,特别是它们混和物的热分解尚未见报道,这给有关钎剂的合成和应用带来很大的盲目性.本文用DTA,DSC,TGA和目测变温法[3]研究了(C2H5)2NH·HCl-C6H10O4和(C2H5)2NH·HCl-C10H18O4两个二元系的相图及其各组成点的热分解温度和行为.1　实验部分(C2H5)2NH·HCl[2],C6H10O4[4](化学纯)在二次去离子水中重结晶,C10H18O4(化学纯)在无水…     

FACTORS AFFECT THE RELEASE OF PSEUDOEPHDRINE HYDROCHLORIDE FROM THE UNCOATED CATION EXCHANGE RESIN-BASED DRUG DELIVERY SYSTEM IN VITRO

1. INTRODUCTIONIn recent years increasing attention has been given to the controlled drug delivery system, which offer a potential advantage over conventional drug therapy. The advantages of a controlled drug release system included localized delivery of the drug to a particular region in the body. This lowers the systemic drug level, increases patient comfort and improves patient compliance. Ion exchange resins are functional polymers that have been used in purification of water, analyti…     

Phase behavior of ternary mannosylerythritol lipid/water/oil systems

Due to the great importance of new therapeutic routes for morphine in pain treatment, several investigations are under development. In this way, the design of a liquid system for the oral administration of morphine would be of great help, especially in patients with difficulties in swallowing (children and elderly people). The systems studied in this work are kollidon^® SR microparticles, a biodegradable polymer classically used as excipient in the design of solid dosage forms, as vehicles for morphine. A detailed investigation of the capabilities of the polymer particles to load this drug at their surface is described. Electrophoretic mobility and optical absorbance determinations were used with this aim. The main factors determining the drug incorporation, after incubation of the microparticles in the morphine solutions, were the adsorption time, the type of electrolyte and its concentration, and the drug concentration. The optimum loading conditions were used to perform morphine release evaluations, finding that the release profiles were biphasic since the drug adsorbed was slowly released during 24 h after an initial burst release phase.     

新型离子液体体系催化苯与1-己烯的烷基化反应

氯化铁;盐酸三乙胺;新型离子液体体系催化苯与1-己烯的烷基化反应     

Studies of Active Ingredients in Cough Syrup by Capillary Zone Electrophoresis with Amperometric Detection

The present paper covers a simple, reliable and reproducible method, based on capillary zone elec-trophoresis (CZE) with amperometric detection(AD), for the separation and the determination of ephedrine hydrochloride, promethazine hydrochloride and codeine phosphate. Under the optimal conditions, the three analytes were base-line separated completely within 16 min. Good linear relationships between the peak heights and the concentrations of the three analytes were obtained with the correlation coefficients better than 0. 9993. The method was directly applied to the determination of the active ingredients in pharmaceutical preparations and the assay results were satisfactory.     

离子对反相高效液相色谱法同时测定复合维生素片中4种水溶性维生素

采用离子对反相高效液相色谱法同时测定了复合维生素片中烟酰胺、维生素B1、维生素B2、维生素B6等4种水溶性维生素的含量。样品经水溶解、过滤后,以Hypersil C18化学键合硅胶为固定相,以甲醇-0.5%(体积分数)醋酸水溶液(含2.5 mmol/L己磺酸钠,pH 2.8)(体积比为18∶82)为流动相,等度洗脱,紫外检测器于280 nm波长下检测。当烟酰胺、维生素B1、维生素B2和维生素B6的质量浓度分别在25450 mg/L,590 mg/L,2.590 mg/L,595 mg/L时,其峰面积与质量浓度的线性关系良好;日内测定平均相对标准偏差(n=7)分别为1.0%,2.2%,1.8%和1.3%;日间测定相对标准偏差(n=5)分别为1.5%,3.6%,2.4%和1.7%。该方法已成功应用于复合维生素片中4种水溶性维生素的同时测定。     

阳离子交换树脂对盐酸麻黄碱交换吸附与解离的研究

研究了强酸型阳离子交换树脂对盐酸麻黄碱的交换吸附与妥离作用。发现在弱碱和酸性溶液中树脂地盐酸麻黄碱的亲和力很强。强碱性环境则不利同树脂的亲和;用2．0Mol/L NaOH或2．0Mol/L HCl作为解离液时的解离效果优于2．0Mol/L NaCl溶液的解离液效果。温度对解离的影响不是很大,在室温条件下进行解离即可取得较好的解离效果。选用了有机溶剂乙醇,乙二醇,乙腈和四氢呋喃作为解离增强剂,以乙醇较为合适,且其浓度在15％左右时较好,在给定离子交换柱中的解离情况,用含2．0Mol/L HCl的15％乙醇地,回收率为91％。     

强酸和弱酸阳离子交换树脂与盐酸维拉帕米的静态交换反应特性研究

离子交换树脂是一类功能高分子材料,本文研究了强酸（001×7）和弱酸（110）阳离子交换树脂与钙通道阻滞剂盐酸维拉帕米（VH）的交换反应特性。结果表明,001×7和110树脂与VH的交换率、树脂载药量及反应平衡常数均分别随温度的升高而增加和减少;298K时,两树脂与VH进行交换反应的自由能ΔG°(kJ/mol) 分别为8.5503和6.0911,交换反应热ΔHm°（kJ/mol）分别为100.29和 -22.77;交换反应熵（kJ/mol·K）分别为0.3077和 -0.0968,表明001×7与VH的交换反应是吸热反应,且属于熵增加的反应,即升高温度有利于交换反应的进行;而110与VH 树脂的交换反应是放热反应,且该反应是熵减少的反应,即升高温度不利于交换反应的进行。     

聚甲基红膜修饰电极的电化学性质及其对盐酸吡哆辛的伏安测定

制备了聚甲基红膜修饰电极 ( PMRE) ,采用循环伏安法、计时库仑法及交流阻抗法对该膜电极的电化学性质进行了初步研究。同时发现 ,聚甲基红膜修饰电极对盐酸吡哆辛 ( VB6 )有良好的伏安响应 ,在较低的扫速下 ,VB6 在该修饰电极上产生一对准可逆氧化还原峰。氧化峰电流与 VB6 浓度在 2× 1 0 - 7～ 1× 1 0 - 2 mol/L范围内有良好的线性关系 ,检测限可达 1× 1 0 - 7mol/L ,用于样品分析 ,取得了满意的结果