Non-invasive Near Infrared Fluorescence Imaging of CdHgTe Quantum Dots in Mouse Model

Near infrared CdHgTe quantum dots (QDs) acted as biomarker for in vivo imaging were synthesized in aqueous solution. The size and the fluorescence wavelength of the synthesized quantum dots can be arbitrary manipulated by using different refluxing time. In particular, the fluorescence wavelength was extended to near infrared range (700∼900 nm), which make the in vivo imaging possible. Meanwhile, the characteristics, such as morphology, size, spectra, stability and toxicity were investigated. The dynamic bio-distribution, clearance from blood, liver and intestine in living animal were in vivo monitored by a NIR imaging system. The circulation of CdHgTe QDs in living mice was addressed semi-quantitatively according to the changes of fluorescence intensity. The high stability as well as high fluorescence intensity makes QDs particular interested candidates for in vivo imaging studies.     

Cortistatin类型天然产物的不对称形式全合成:金催化串联Semi-Pinacol重排反应策略

本工作详细报道了Cortistatin类型天然产物不对称形式全合成的研究路线.以近期作者发展的金催化串联semi-pinacol重排反应构建[3,2,1]七元氧桥环结构的方法学为基础,进一步将其应用于复杂体系,高效构建了Cortistatin类型天然产物独特的七元氧桥环核心骨架,从而完成了该类型天然产物的不对称形式全合成.     

COMPREHENSIVE MATHEMATICAL MODEL OF MICROCIRCULATORY DYNAMICS (Ⅰ)——BASIC THEORY

Under the basis of physiological data, a nonlinear and unsteady comprehensive mathematical model of microcirculatory dynamics with distributed parameters is developed. Hemodynamics, interstitium dynamics, lymph dynamics, dynamics of protein transport, oxygen dynamics, dynamics of heat transfer, and myogenic and metabolic regulation procedures are included. The interactions between these factors were comprehensively exhibited. The influences of arteriolar vasomotion and nonlinear viscoelasticity of blood in arteriole are considered. A simplified vessel network consisting of arteriole, open and reserved capillaries, venule, initial lymphatics and arteriole-venule anastomose is adopted as the geometrical model. This kind of comprehensive mathematical model is helpful in analyzing clinical data and developing a “numerical experiment method” in microcirculation research.     

A binuclear manganese(II) complex,deca­aqua(μ‐1,2,4,5‐benzene­tetra­carboxyl­ato‐O1:O4)­di­manganese(II) hydrate

In the title Mn^II complex, [Mn₂(C₁₀H₂O₈)(H₂O)₁₀]·H₂O, two independent binuclear mol­ecules bridged by the 1,2,4,5‐benzene­tetra­carboxyl anion exist in a unit cell, with each anion lying about an inversion centre. One of the Mn—O_water distances [2.2922 (13) Å] is significantly longer than the Mn^II—O_water distances reported so far for Mn^II complexes and very close to the Mn—O_water distances found in the axial direction of Mn^III complexes.     

冠状动脉CTA定量评估稳定型心绞痛患者斑块进展及其在心血管事件中的预测价值

本文对非创伤性血管成像技术(CTA)定量评估稳定型心绞痛患者的冠状动脉斑块进展及其在心血管事件中的预测价值进行了分析。选取2017年1月~2017年12月我院心血管科142例因新发症状或症状加重随访行两次冠状动脉CT血管造影(CCTA)的稳定型心绞痛患者作为研究对象,根据后期随访患者是否有主要不良心脏事件发生进行分组,其中82例发生主要不良心脏事件的患者作为观察组,60例未发生主要不良心脏事件的患者作为对照组,定量评估稳定型心绞痛患者斑块的进展情况。结果显示:观察组患者有糖尿病、高血脂、吸烟史的比例均高于对照组,差异有统计学意义(P<0.05)。两组随访CCTA总体斑块负荷率、冠状动脉直径狭窄率比较差异有统计学意义(P<0.05);两组斑块进展方面,脂质斑块负荷率、纤维斑块负荷率、钙化斑块负荷率、总体斑块负荷率、冠状动脉直径狭窄率比较差异有统计学意义(P<0.05)。通过多因素Logisitic回归分析,脂质斑块负荷进展与基线高血脂有关(P<0.05),总体斑块负荷进展与基线高血脂具有相关性(P<0.05),冠状动脉直径狭窄率进展与糖尿病、高血脂、吸烟史具有相关性(P<0.05)。本文证实了CCTA检查是检测稳定型心绞痛患者斑块负荷进展的一种有效方法,且心血管危险因素能加快稳定型心绞痛患者负荷进展。     

一种测量GaAs-GaAlAs行波激光放大器增益特性的实验方法

本文报导了一种测量光耦合效率η的新实验方法。这个方法是建立于p-n结短路光电流原理上的。本文推导出适合于行波激光放大器的光耦合效率的公式。短路光电流用一检流计测量,利用公式获得光耦合效率的实验值。利用实验所测光耦合效率,测量了行波激光放大器的增益随注入电流变化的规律,其结果和实验符合。另外本文还介绍了在脉冲注入电流条件下测行波半导体激光放大器增益的实验方法。     

镧对锌阳极带低温脆性的影响

研究了镧的加入对锌阳极带韧脆转变温度的影响,并对其金相组织进行了观察.结果表明,适量镧对于改善锌阳极带的综合性能具有重要作用.同不含镧的锌带相比,加入0.1%镧的锌带的韧脆转变温度变化不大,加入0.3%镧的锌带的韧脆转变温度降低明显.添加适量镧后,锌阳极带组织性能也发生了变化.晶粒度从原来的6.5～7级变为8～9级左右.适量镧可以细化晶粒,改善内部组织,提高锌阳极带的综合性能.     

磺基水杨酸盐的晶体结构和倍频效应

用X射线单晶衍射法测定了三水合二（5－磺基水杨酸）钙（C（14）H1（10）O（12）S2Ca·3H2O，1）和二水合（5－磺基水杨酸）二钾（C7H4O6SK2·2H2O，2）的晶体结构·化合物1属单斜晶系，空间群为Pn。，晶胞参数a＝5．604（1），B＝18．560（4），c＝10．006（2），β＝102．19（3）°，Z＝2，最终R＝0．0244．化合物2属正交晶系，空间群Pbca，晶胞参数a＝25．841（5），b＝12．186（2），c＝7．739（2），Z＝8，最终R＝0．0308．化合物1粉末倍频效应为2．86倍KH2PO4，其厘米级单晶体的紫外端吸收边经在375nm附近     

Syntheses,Structures, and Properties of Lanthanide Supramolecular Complexes with 1, 10‐Phenanthroline and Terminal Amino Acids with Different Chain Lengths

Four lanthanide supramolecular coordination compounds, [Eu(gly)₂(phen)₂(H₂O)₂](ClO₄)₃(phen)₄ · H₂O ( 1 ), [Eu₂(APA)₆(phen)₂](ClO₄)₆(phen)₄ · 3H₂O ( 2 ), [Tb₂(ABA)₄(phen)₄](ClO₄)₆(phen)₄ ( 3 ), and [Eu₂(AHA)₄(phen)₄](ClO₄)₆(phen)₂ · 2H₂O · 2C₂H₅OH ( 4 ) (gly = glycine, APA = 3‐aminopropionic acid, ABA = 4‐aminobutanoic acid, AHA = 6‐aminohexanoic acid, phen = 1, 10‐phenanthroline), were synthesized and characterized by single crystal X‐ray diffraction. Compound 1 has a 2‐D supramolecular layered structure of mononuclear coordination cations and free phen molecules connected via hydrogen bonding and π‐π stacking interactions. 2 forms a 3‐D supramolecular network by hydrogen bonding between binuclear coordination cations and free phen molecules, between coordination cations and lattice water molecules, and π‐π stacking interactions between free phen molecules. Compounds 3 and 4 form 2‐D supramolecular structures with π‐π stacking between coordinating phen molecules, and between free phen molecules hydrogen‐bonded to the binuclear coordination cations. The high‐resolution emission spectra show only one Eu³⁺ ion site in the title complexes. The aqueous solutions of the title complexes are all photochromic with the color of the solution changing from yellow to green when irradiated by mercury lamp. During the decoloration process, they return to yellow color.