[mü]MAD, the adhesion based dynamic micro-manipulator

In this paper, a micro-manipulation method based on adhesion forces and dynamic effects is proposed. A prototype manipulator, called [mü]MAD, has been constructed and successfully experimented. Moreover, the advanced capabilities of [mü]MAD, especially two new interesting applications, are presented: sorting of micro-objects and mechanical characterizations.     

Hydro­gen bonding in 2-(hydroxy­methyl)-1,3-propane­diol and N,N′-bis­[2-hydroxy-1,1-bis­(hydroxy­methyl)­ethyl]­malon­amide

The mol­ecule of 2-(hydroxy­methyl)-1,3-propane­diol, C₄H₁₀O₃, lies across a mirror plane in space group P2₁/m, with disorder of both terminal hydroxyl H atoms. The molecules are linked by three O—H⋯O hydrogen bonds which combine to form sheets; in each O—H⋯O bond, the H atom resonates between the two O atoms. In the crystal structure of N,N′-­bis­[2-hydroxy-1,1-bis­(hydroxy­methyl)­ethyl]­malon­amide, C₁₁H₂₂N₂O₈, the molecule lies about a twofold axis and has four strong hydrogen bonds which form a mixture of chains and dimers; these combine to give a three-dimensional supramolecular framework.     

Photolithographic Encoding of Metal Complexes

A platform technology for the creation of spatially resolved surfaces encoded with a monolayer consisting of different metal complexes was developed. The concept entails the light‐triggered activation of a self‐ assembled monolayer (SAM) of UV‐labile anchors, that is, phenacylsulfides, and the subsequent cycloaddition of selected diene‐functionalized metal complexes at defined areas on the surface. The synthesis and characterization of the metal complexes for the UV‐light assisted anchoring on the surface and a detailed study of a short‐chain oligomer model system in solution confirm the high efficiency of the photoreaction. The hybrid materials obtained by this concept can potentially be utilized for the design of highly valuable catalytic or (opto‐)electronic devices.     

On Some Methods to Derive Necessary and Sufficient Optimality Conditions in Vector Optimization

The aim of this paper is to address new approaches, in separate ways, to necessary and, respectively, sufficient optimality conditions in constrained vector optimization. In this respect, for the necessary optimality conditions that we derive, we use a kind of vectorial penalization technique, while for the sufficient optimality conditions we make use of an appropriate scalarization method. In both cases, the approaches couple a basic technique (of penalization or scalarization, respectively) with several results in variational analysis and optimization obtained by the authors in the last years. These combinations allow us to arrive to optimality conditions which are, in terms of assumptions made, new.     

Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes

Ergot alkaloids are toxins and important pharmaceuticals which are produced biotechnologically on an industrial scale. They have been identi?ed in two orders of fungi and three families of higher plants. The most important producers are fungi of the genera Claviceps, Penicillium and Aspergillus (all belonging to the Ascomycota). Chemically, ergot alkaloids are characterised by the presence of a tetracyclic ergoline ring, and can be divided into three classes according to their structural features, i.e. amide- or peptide-like amide derivatives of D-lysergic acid and the clavine alkaloids. Signi?cant progress has been achieved on the molecular biological and biochemical investigations of ergot alkaloid biosynthesis in the last decade. By gene cloning and genome mining, gene clusters for ergot alkaloid biosynthesis have been identi?ed in at least 8 different ascomycete species. Functions of most structure genes have been assigned to reaction steps in the biosynthesis of ergot alkaloids by gene inactivation experiments or biochemical characterisation of the overproduced proteins.     

Kinetic analysis of the estrogen receptor alpha using RIfS

The label-free time-resolved reflectometric interference spectroscopy has been used to study the interaction of the human estrogen receptor alpha (ERa) and different types of ligands. Different possible sensor surface coatings including various estrogen derivatives were evaluated for their suitability for detection of ERa. The determination of the kinetic and thermodynamic constants was carried out for the interaction in the heterogeneous phase as well as for the interaction in homogeneous phase. In addition, the affinity of 11 ligands ranging from natural hormones and pharmaceuticals to endocrine disrupting chemicals (EDCs) has been determined with this label-free assay format.     

Bernstein�CWalsh Type Theorems for Real Analytic Functions in Several Variables

The aim of this paper is to extend the classical maximal convergence theory of Bernstein and Walsh for holomorphic functions in the complex plane to real analytic functions in ℝ ^N . In particular, we investigate the polynomial approximation behavior for functions F:L→ℂ, L={(Re z,Im z):z∈K}, of the structure F=g[`(h)]F=g\overline{h}, where g and h are holomorphic in a neighborhood of a compact set K⊂ℂ <sup>N</sup> . To this end the maximal convergence number ρ(S <sub>c</sub> ,f) for continuous functions f defined on a compact set S <sub>c</sub> ⊂ℂ <sup>N</sup> is connected to a maximal convergence number ρ(S <sub>r</sub> ,F) for continuous functions F defined on a compact set S <sub>r</sub> ⊂ℝ <sup>N</sup> . We prove that ρ(L,F)=min {ρ(K,h)),ρ(K,g)} for functions F=g[`(h)]F=g\overline{h} if K is either a closed Euclidean ball or a closed polydisc. Furthermore, we show that min {ρ(K,h)),ρ(K,g)}≤ρ(L,F) if K is regular in the sense of pluripotential theory and equality does not hold in general. Our results are based on the theory of the pluricomplex Green’s function with pole at infinity and Lundin’s formula for Siciak’s extremal function Φ. A properly chosen transformation of Joukowski type plays an important role.