Synthesis and study of iodonium borate salts as photoinitiators

Iodonium butyltriphenylborate salts (A I⁺ Ar′Ph₃B⁻ R), (Bu) were found to be more efficient than iodonium tetraphenylborate salts (RPh) when used as photoinitiators for the polymerization of acrylates. Relative photodecomposition rates were also different. It was found from a study of the photoreaction of iodonium borate salts with a model monomer, methyl methacrylate, that iodonium butyltriphenylborate salts simultaneously produce a butyl radical from the borate anion and an aryl radical from the iodonium cation upon irradiation. Both radicals initiate polymerization. Iodonium tetraphenylborate salts were found to release an aryl radical, but only from the iodonium cation. Iodonium borate salts exhibit strong absorption below 300 nm with a tail absorption above 400 nm. Thus, iodonium butyltriphenyl borate salts are efficient photoinitiators even when used with visible light. When a photosensitizer such as 5,7-diiodo-3-butoxy-6-fluorone is employed, iodonium butyltriphenylborate salts are rendered much more efficient for visible light photopolymerization. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 1667–1677, 1998     

流体晃动时域双协边界元法分析

利用双协边界元法在时域内对流体晃动问题进行分析,推导出边界积分方程及相应的边界条件。分析过程中考虑流体的粘性,自由面上的动力学条件为法向正应力和切向剪应力为零。固壁面上采用流体质点与固壁质点速度相等的条件。时域的离散采用差分法,并利用时间步迭代,逐步追踪流体自由面,在流体的不断变动的边界上考虑其边界条件。数值结果表明本文的双协边界元法是可行的。     

A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters

Glycosidases, which are the enzymes responsible for the removal of residual monosaccharides from glycoconjugates, are involved in many different biological and pathological events. The ability to detect sensitively the activity and spatiotemporal distribution of glycosidases in cells will provide useful tools for disease diagnosis. However, the currently developed fluorogenic probes for glycosidases are generally based on the glycosylation of the phenol group of a donor–acceptor type fluorogen. This molecular scaffold has potential drawbacks in terms of substrate scope, sensitivity because of aggregation-caused quenching (ACQ), and the inability for long-term cell tracking. Here, we developed glycoclusters characterized by aggregation-induced emission (AIE) properties as a general platform for the sensing of a variety of glycosidases. To overcome the low chemical reactivity associated with phenol glycosylation, here we developed an AIE-based scaffold, which is composed of tetraphenylethylene conjugated with dicyanomethylene-4H-pyran (TPE–DCM) with a red fluorescence emission. Subsequently, a pair of dendritic linkages was introduced to both sides of the fluorophore, to which six copies of monosaccharides (d-glucose, d-galactose or l-fucose) were introduced through azide–alkyne click chemistry. The resulting AIE-active glycoclusters were shown to be capable of (1) fluorogenic sensing of a diverse range of glycosidases including β-d-galactosidase, β-d-glucosidase and α-l-fucosidase through the AIE mechanism, (2) fluorescence imaging of the endogenous glycosidase activities in healthy and cancer cells, and during cell senescence, and (3) glycosidase-activated, long-term imaging of cells. The present study provides a general strategy to the functional, in situ imaging of glycosidase activities through the multivalent display of sugar epitopes of interest onto properly designed AIE-active fluorogens.

We report a general strategy for the fluorogenic sensing of glycosidases in cells based on aggregation-induced emission of glycoclusters.     

东方超环上低杂波驱动等离子体环向旋转实验研究

旋转和旋转剪切能抑制磁流体不稳定性和增强等离子体约束.低杂波电流驱动作为未来聚变堆上可能的旋转驱动手段,探索低杂波在现有托卡马克装置上驱动等离子体旋转的驱动机制,可以为未来的聚变堆上旋转预测提供重要参考.在东方超环托卡马克装置上,早期发现了2.45 GHz的低杂波能有效驱动等离子体旋转的现象,认为是边界旋转的改变导致芯部旋转的同电流方向的增加造成的.更高频率下4.6 GHz低杂波电流驱动可以更有效地驱动同电流方向的等离子体旋转.本论文分析在欧姆背景等离子体下,不同功率的低杂波对等离子体环向旋转的影响,研究安全因子剖面变化对环向旋转的关系,利用功率调制获得了低杂波驱动旋转实验中的环向动量输运系数变化情况,发现环向动量扩散系数(χφ)、环向动量箍缩系数(Vpinch)的数值大小趋势是从芯部向靠外的区域逐渐变大.这与低杂波驱动环向旋转时,环向旋转速度由靠外的区域向芯部传递的特性吻合.     

基于悬丝法的螺线管磁轴测量信号处理技术

针对螺线管磁轴测量中的悬丝位置、测量信号失真、磁轴偏轴和磁轴倾斜信号的分离数据处理要求等问题,采用一种高偏置消除的信号检测与测量方法,并对探测器采用了相关的恒定驱动技术,进一步提高了信号产生的稳定性及抗干扰能力,研制了一种可以获得比较直接的悬丝振动信号的测量系统,解决了单纯采用交流耦合隔直滤波放大器或带通滤波放大器不能获得完全准确的测量信号的问题,确保了在较高的直流偏置下获得没有畸变的较小测量信号,消除了测量信号中低频分量基线倾斜及其中起伏的影响,并实现了磁轴偏移和磁轴倾斜信号的分离,极大地提高了螺线管线圈磁轴的测量灵敏度,实际测试结果显示测量灵敏度提高约1个量级。     

The Role of Sulfur in the S-PtRe/Al2O3 Catalysts: The Endogenous Deposition Effect on the Metal/acid Micro-environment

Alumina is widely used as support in the industrial catalytic process. As a common impurity, the sulfur species, which are often considered a harmful component, play a positive role in some petrochemical reactions. Herein, the S-modified catalysts were fabricated using the exogenous/endogenous deposition method to study the effect of the sulfur induced by introduction approaches. Series characterizations reveal that the exogenous sulfur from the sulfidation treatment affects the active metals by poisoning the low-coordinated sites, leading to the active metal sites decrease. As for the endogenous deposition method, besides the poison effect, the removal of the endogenous sulfur from the S-contain alumina support can produce oxygen vacancies, which can not only act as acid sites but work as an electron acceptor that optimizes the catalyst electronic structure. Benefits from the effect of endogenous sulfur, the catalyst with a suitable catalytic metal/acid micro-environment exhibit the best dehydrocyclization performance.     

Immuno-Desorption Electrospray Ionization Mass Spectrometry Imaging Identifies Functional Macromolecules by Using Microdroplet-Cleavable Mass Tags

We present immunoassay-based desorption electrospray ionization mass spectrometry imaging (immuno-DESI-MSI) to visualize functional macromolecules such as drug targets and cascade signaling factors. A set of boronic acid mass tags (BMTs) were synthesized to label antibodies as MSI probes. The boronic ester bond is employed to cross-link the BMT with the galactosamine-modified antibody. The BMT can be released from its tethered antibody by ultrafast cleavage of the boronic ester bond caused by the acidic condition of sprayed DESI microdroplets containing water. The fluorescent moiety enables the BMT to work in both optical and MS imaging modes. The positively charged quaternary ammonium group enhances the ionization efficiency. The introduction of the boron element also makes mass tags readily identified because of its unique isotope pattern. Immuno-DESI-MSI provides an appealing strategy to spatially map macromolecules beyond what can be observed by conventional DESI-MSI, provided antibodies are available to the targeted molecules of interest.     

变厚度薄板静力分析的一种方法

应用有限元法 ,建立了变厚度薄板三角形单元刚度矩阵 ,给出了变厚度薄板三角形单元形心上的应力和位移计算的数学模型。通过对某型反坦克导弹弹翼进行静力分析和实验比较 ,表明采用这种模型进行分析合乎结构设计精度要求