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1.
Werner Seebacher Reto Brun Robert Saf Robert Weis 《Monatshefte für Chemie / Chemical Monthly》2003,17(9):1411-1420
4-Aminobicyclo[2.2.2]octanones were converted to their N-oxides and to 4-aminobicyclo[2.2.2]octanes. Furthermore, the 6,7-bis-(4-methoxyphenyl) analogues were synthesized. All products were screened for their activities against Trypanosoma b. rhodesiense and Plasmodium falciparum. The pharmacological results were compared with those of formerly tested bicyclo[2.2.2]octanones and bicyclo[2.2.2]octanols. Structure-activity relationships are discussed. 相似文献
2.
Gerald Schwarzenbacher Marion S. Gangl Marian Goriup Martin Winter Matthias Grunert Franz Renz Wolfgang Linert Robert Saf 《Monatshefte für Chemie / Chemical Monthly》2001,132(4):519-529
Summary. 11-(4H-1,2,4-Triazol-4-yl)-undecylmethacrylate (1), a new ligand for Fe(II) spin-crossover (SCO) complexes containing a polymerizable group, was synthesized and characterized.
The complex [Fe·1
3](BF4)2 (2) was obtained by reaction of 1 with Fe(BF4)2·6H2O (molar ratio 1/Fe(II) = 3/1) in THF. Complex 2 showed a gradual spin-crossover between 80 and 230 K. The methacrylate units in the ligands of complex 2 could be oligomerized radically in solution (initiator: azoisobutyronitrile) without loss of the spin-crossover behaviour.
Received May 30, 2000. Accepted December 10, 2000 相似文献
3.
Synthesis and characterization of four iridium(III)-octaethylporphyrins and a π-extended iridium(III)-benzoporphyrin are presented. Strong room-temperature phosphorescence was observed for all of the complexes with quantum yields of up to 30 %. Axial ligands were introduced to tune the photophysical properties and the solubility. Complexes bearing lipophilic ligands such as pyridine or N-(n-butyl)imidazole were incorporated into polystyrene to obtain optical oxygen sensors. Covalent coupling of the dye is possible by introduction of ligands with binding domains (1-imidazoleacetic acid). This enabled preparation of a water-soluble oxygen probe (by staining bovine serum albumin) and a trace oxygen sensor (by coupling to amino-modified silica gel). 相似文献
4.
Robert Weis Reto Brun Robert Saf Werner Seebacher 《Monatshefte für Chemie / Chemical Monthly》2003,134(7):1019-1026
Summary. 4-Aminobicyclo[2.2.2]octanones which were prepared in one-pot-reactions from benzylidene acetone and dialkylammonium rhodanides
were reduced stereoselectively to their corresponding alcohols. The activities of the bicyclic compounds against causative
organisms of tropical deseases were examined. The 4-aminobicyclo[2.2.2]octan-2-ols were in general more active against Trypanosoma b. rhodesiense and Plasmodium falciparum than the corresponding keto compounds.
Corresponding author. E-mail: robert.weis@uni-graz.at
Received November 27, 2002; accepted December 2, 2002
Published online May 2, 2003 相似文献
5.
Baikousi M Bourlinos AB Douvalis A Bakas T Anagnostopoulos DF Tuček J Safářová K Zboril R Karakassides MA 《Langmuir : the ACS journal of surfaces and colloids》2012,28(8):3918-3930
Magnetic Fe(2)O(3)/carbon hybrids were prepared in a two-step process. First, acetic acid vapor interacted with iron cations dispersed on the surface of a nanocasted ordered mesoporous carbon (CMK-3). In the second step, the primarily created iron acetate species underwent pyrolysis and transformed to magnetic iron oxide nanoparticles. X-ray diffraction, Fourier-transform infrared, and Raman spectroscopies were used for the chemical and structural characterization of the hybrids, while surface area measurements, thermal analysis, and transmission electron microscopy were employed to determine their physical, surface, and textural properties. These results revealed the preservation of the host carbon structure, which was homogenously and controllably loaded (up to 27 wt %) with nanosized (ca. 20 nm) iron oxides inside the mesoporous system. M?ssbauer spectroscopy and magnetic measurements at low temperatures confirmed the formation of γ-Fe(2)O(3) nanoparticles exhibiting superparamagnetic behavior. The kinetic studies showed a rapid removal of Cr(VI) ions from the aqueous solutions in the presence of these magnetic mesoporous hybrids and a considerably increased adsorption capacity per unit mass of sorbent in comparison to that of pristine CMK-3 carbon. The results also indicate highly pH-dependent sorption efficiency of the hybrids, whereas their kinetics was described by a pseudo-second-order kinetic model. Taking into account the simplicity of the synthetic procedure and possibility of magnetic separation of hybrids with immobilized pollutant, the developed mesoporous nanomaterials have quite real potential for applications in water treatment technologies. 相似文献
6.
Werner Seebacher Marcel Kaiser Reto Brun Robert Saf Robert Weis 《Monatshefte für Chemie / Chemical Monthly》2007,138(7):709-714
Summary. We synthesized several 4-aminobicyclo[2.2.2] octan-2-ols and 4-amino-2-azabicyclo[3.2.2]nonanes from epimerized 4-amino-bicyclo[2.2.2]octan-2-ones.
The new compounds were tested for their activity against Trypanosoma b. rhodesiense, the causative organism of East African sleeping sickness, and Plasmodium falciparum K
1, a multiresistant protozoan parasite which causes Malaria tropica. The results are compared to the activities of their formerly
synthesized stereoisomers and structure–activity relationships are discussed. 相似文献
7.
Werner?Seebacher Reto?Brun Robert?Saf Robert?WeisEmail author 《Monatshefte für Chemie / Chemical Monthly》2003,134(10):1411-1420
Summary. 4-Aminobicyclo[2.2.2]octanones were converted to their N-oxides and to 4-aminobicyclo[2.2.2]octanes. Furthermore, the 6,7-bis-(4-methoxyphenyl) analogues were synthesized. All products were screened for their activities against Trypanosoma b. rhodesiense and Plasmodium falciparum. The pharmacological results were compared with those of formerly tested bicyclo[2.2.2]octanones and bicyclo[2.2.2]octanols. Structure-activity relationships are discussed.Received April 8, 2003; accepted April 14, 2003
Published online September 25, 2003 相似文献
8.
Erbilen Nesibe Zor Erhan Saf Ahmet Ozgur Akgemci Emine Guler Bingol Haluk 《Journal of Solid State Electrochemistry》2019,23(9):2695-2705
Journal of Solid State Electrochemistry - Chirality is a universal characteristic of natural systems and discrimination of enantiomers of a chiral molecule plays a major role particularly in... 相似文献
9.
Robert Weis Marcel Kaiser Reto Brun Robert Saf Werner Seebacher 《Monatshefte für Chemie / Chemical Monthly》2006,31(6):1365-1374
4-Aminobicyclo[2.2.2]octan-2-ones and -ols showed activity against the causative organisms of East African sleeping sickness
and Malaria tropica. Several imino derivatives of the ketones were more active. Now hydrazono analogues and 3-hydroximino
derivatives of the ketones and alcohols were synthesized. The structures of the obtained isomers were elucidated by NMR spectroscopy.
A single phenylhydrazone exhibited quite good antitrypanosomal activity in the range of already known imino analogues. 相似文献
10.