全息图模压复制技术(Ⅲ)——模压复制及热冲压转印技术

模压复制是形成全息产品的最后一道工序,它类似凸版印刷,因而可以实现机械化大规模生产。本文介绍了平压、滚压工艺过程及所用的原材料及设备,同时还介绍了将模压全息图应用到别的载体材料上的热冲压转印技术。     

Detection of mutant p53 using field-effect transistor biosensor

We assessed the abilities of wild p53 and mutant p53 proteins to interact with the consensus DNA-binding sequence using a MOSFET biosensor. This is the first report in which mutant p53 has been detected on the basis of DNA-protein interaction using a FET-type biosensor. In an effort to evaluate the performance of this protocol, we constructed the core domain of wild p53 and mutant p53 (R248W), which is DNA-binding-defective. After the immobilization of the cognate DNA to the sensing layer, wild p53 and mutant p53 were applied to the DNA-coated gate surface, and subsequently analyzed using a semiconductor analyzer. As a consequence, a significant up-shift in drain current was noted in response to wild p53, but not mutant p53, thereby indicating that sequence-specific DNA-protein interactions could be successfully monitored using a field-effect-based biosensor. These data also corresponded to the results obtained using surface plasmon resonance (SPR) measurements. Taken together, our results show that a FET-type biosensor might be promising for the monitoring of mutant p53 on the basis of its DNA-binding activity, providing us with very valuable insights into the monitoring for diseases, particularly those associated with DNA-protein binding events.     

Thermal annealing effects on the dynamic photoresponse properties of Al-doped ZnO nanowires network

In this study, UV photodetectors based on a network of aluminium-doped zinc oxide (AZO) nanowires were manufactured at a low cost; for this purpose, a fast and simple fabrication process that involved dropping nanowires dispersion solution was employed instead of the conventional e-beam lithography process that is used to manufacture single nanowire–based UV photodetectors. It was demonstrated that nanowire network–based UV photodetectors provide a much faster UV photoresponse than conventional single nanowire–based UV photodetectors. The fast UV photoresponse of the fabricated UV photodetector can be attributed to the fact that the potential barriers formed in the nanowire network junctions effectively block the flow of electrons during the process of photocurrent decay. Furthermore, the UV photoresponse under illumination by a 254 nm UV source was studied as a function of the annealing temperature of the AZO nanowires network at a bias of 5 V. The fabricated UV photodetector showed the fastest response of 2 s to UV illumination in air when the sample was annealed in air for 1 h at 300 °C.     

Non-conflicting ordering cones and vector optimization in inductive limits

Let (E, ξ)= ind (E_n, ξ_n) be an inductive limit of a sequence (E_n, ξ_n)_{n∈ N} of locally convex spaces and let every step (E_n, ξ_n) be endowed with a partial order by a pointed convex (solid) cone S_n. In the framework of inductive limits of partially ordered locally convex spaces, the notions of lastingly efficient points, lastingly weakly efficient points and lastingly globally properly efficient points are introduced. For several ordering cones, the notion of non-conflict is introduced. Under the requirement that the sequence (S_n)_{n∈ N} of ordering cones is non-conflicting, an existence theorem on lastingly weakly efficient points is presented. From this, an existence theorem on lastingly globally properly efficient points is deduced.     

SYNTHESIS OF MELEZITOSE DERIVATIVES

The reactivity of melezitose hydroxyls is studied during tritylation in pyridine. Some novel derivatives of melezitose are prepared. An acetyl is transferred from the 4- to the 6-position after detritylation of 3 and 4. The structures of the products are proved by elemental analysis; ¹ H, ¹³ C, and ¹ H- ¹ H COSY NMR spectra;IR spectra; and fast-atom bombardment mass spectrometry.     

Predicting melting temperature directly from protein sequences

Proteins of both hyperthermophilic and mesophilic microorganisms generally constitute from the same 20 amino acids; however, the extent of thermal tolerance of any given protein is an inherent property of its amino acid sequence. The present study is the first to report a rapid method for predicting Tm (melting temperature), the temperature at which 50% of the protein is unfolded, directly from protein sequences (the Tm Index program is available at http://tm.life.nthu.edu.tw/). We examined 75 complete microbial genomes using the Tm Index, and the analysis clearly differentiated hyperthermophilic from mesophilic microorganisms on this global genomic basis. These results are consistent with the previous hypothesis that hyperthermophiles express a greater number of high Tm proteins compared with mesophiles. The Tm Index will be valuable for modifying existing proteins (enzymes, protein drugs and vaccines) or designing novel proteins having a desired melting temperature.     

GENERAL OPEN MAPPING THEOREMS FOR LINEAR TOPOLOGICAL SPACES

0IntroductionIntile1930's,thefirstoped1flappingtheoremforFr6clletspaceswasprovedbyS.B....htll].Sincethedtilevariousextellsiollsoftheopenmappingtheoremhaveapl)earedillsuccessiollforitsapplications(fordetails,see[4]).In1958,V.PtAkfoundoutthatoped1llappillgtheoremsareconllectedwithsolllecompleteness,alldheobtainedastrikillgextensiollofBallach'sclassicaltlleoreul,whichpoilltsoutthatcontinuouslillearmapsfi.olllB-colllpletespacesolltobarrelledspacesareoped['].1111965,T.Husaingaveaninlportalltope…     

大气声传播通道的声源当量估计方法

提出了一种基于大气声传播通道的爆炸声源能量估计方法,通过将计算大气声学的传播能量分布结果与大气中传播的声压幅度衰减模型相结合,使用平流层通道与热层通道传播损失能量比例作为修正量,提高了对爆炸声源能量的估计精度。在多次地面爆炸实验得到的数据中,使用观测距离800 km以上且同时存在平流层通道与热层通道的次声接收信号,对比了平流层顶风速修正的能量估计方法与该文提出的基于大气声传播通道的能量估计方法。实验结果验证了相对于传统风速修正的能量估计方法,该方法可显著降低估计误差。     

随机振动的信息量及最大熵概率估计

本文将信息量等概念及最大熵的概率估计方法引入随机振动信号分析,给出随机振动的信息量及信息熵的概念,讨论了随机振动的信息描述.最后以复合振动信号为例,给出它的最大熵概率密度函数.     

Altering the Position of Phenyl Substitution to Adjust Film Morphology and Memory Device Performance

In this study, two structural isomers α‐PBT and β‐PBT, which only differ in the phenyl substituent position on the quinoline chromophore, have been designed and successfully synthesized. The influences of substituent position on the film morphology and the storage performance of the devices were investigated. Both molecules employed in the memory devices exhibited same nonvolatile binary (write‐once‐read‐many‐times; WORM) characteristics, but the switch threshold voltage (Vth) of the β‐PBT‐based device was clearly lower than that of the α‐PBT‐based device. Simulation results demonstrate that the variation of the phenyl substituent position led to different intermolecular stacking styles and thus to varied grain sizes for each film morphology. This work illustrates that altering the phenyl substituent position on the molecular backbone could improve the quality of the film morphology and reduce power consumption, which is good for the rational design of future advanced organic memory devices (OMDs).