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1.
Radiofrequency ablation is the most common minimally invasive therapy used in the United States to treat hepatocellular carcinoma and liver metastases. The ability to perform real-time temperature imaging while a patient is undergoing ablation therapy may help reduce the high recurrence rates following ablation therapy. Ultrasound echo signals undergo time shifts with increasing temperature due to sound speed and thermal expansion, which are tracked using both 1D cross correlation and 2D block matching based speckle tracking methods. In this paper, we present a quantitative evaluation of the accuracy and precision of temperature estimation using the above algorithms on both simulated and experimental data.A finite element analysis simulation of radiofrequency ablation of hepatic tissue was developed. Finite element analysis provides a method to obtain the exact temperature distribution along with a mapping of the tissue displacement due to thermal expansion. These local displacement maps were combined with the displacement due to speed of sound changes and utilized to generate ultrasound radiofrequency frames at specified time increments over the entire ablation procedure. These echo signals provide an ideal test-bed to evaluate the performance of both speckle tracking methods, since the estimated temperature results can be compared directly to the exact finite element solution. Our results indicate that the 1D cross-correlation (CC) method underestimates the cumulative displacement by 0.20 mm, while the underestimation with 2D block matching (BM) is about 0.14 mm after 360 s of ablation. The 1D method also overestimates the size of the ablated region by 5.4% when compared to 2.4% with the 2D method after 720 s of ablation. Hence 2D block matching provides better tracking of temperature variations when compared to the 1D cross-correlation method over the entire duration of the ablation procedure. In addition, results obtained using 1D cross-correlation diverge from the ideal finite element results after 7 min of ablation and for temperatures greater than 65 °C.In a similar manner, experimental results presented using a tissue-mimicking phantom also demonstrate that the maximum percent difference with 2D block matching was 5%, when compared to 31% with the 1D method over the 700 s heating duration on the phantom. 相似文献
2.
This paper gives an overview of the methods developed for tissue motion estimation using transverse oscillation images (TO). TO images are specific radiofrequency ultrasound images featuring oscillations in both spatial directions. The initial studies on TO were published in the late 1990s. This paper reviews the main ideas and applications behind this motion estimation approach. First the origin and motivation of TO is briefly reviewed. Then the beamforming methods that lead to TO images are given, detailing the receive-only approach and the transmit-and-receive approach using synthetic aperture data. The different medical applications where TO has been used are discussed (blood flow, elastography and echocardiography), showing how it can improve motion estimation. Finally, the future perspectives of TO are outlined. 相似文献
3.
Mohammad Arafat Hussain Farzana Alam Sharmin Akhtar Rupa Rayhana Awwal Soo Yeol Lee Md. Kamrul Hasan 《Ultrasonics》2014
Elasticity imaging techniques with built-in or regularization-based smoothing feature for ensuring strain continuity are not intelligent enough to prevent distortion or lesion edge blurring while smoothing. This paper proposes a novel approach with built-in lesion edge preservation technique for high quality direct average strain imaging. An edge detection scheme, typically used in diffusion filtering is modified here for lesion edge detection. Based on the extracted edge information, lesion edges are preserved by modifying the strain determining cost function in the direct-average-strain-estimation (DASE) method. The proposed algorithm demonstrates approximately 3.42–4.25 dB improvement in terms of edge-mean-square-error (EMSE) than the other reported regularized or average strain estimation techniques in finite-element-modeling (FEM) simulation with almost no sacrifice in elastographic-signal-to-noise-ratio (SNRe) and elastographic-contrast-to-noise-ratio (CNRe) metrics. The efficacy of the proposed algorithm is also tested for the experimental phantom data and in vivo breast data. The results reveal that the proposed method can generate a high quality strain image delineating the lesion edge more clearly than the other reported strain estimation techniques that have been designed to ensure strain continuity. The computational cost, however, is little higher for the proposed method than the simpler DASE and considerably higher than that of the 2D analytic minimization (AM2D) method. 相似文献
4.
A pilot study was carried out to investigate the performance of ultrasound stiffness imaging methods namely Ultrasound Elastography Imaging (UEI) and Acoustic Radiation Force Impulse (ARFI) Imaging. Specifically their potential for characterizing different classes of solid mass lesions was analyzed using agar based tissue mimicking phantoms. Composite tissue mimicking phantom was prepared with embedded inclusions of varying stiffness from 50 kPa to 450 kPa to represent different stages of cancer. Acoustic properties such as sound speed, attenuation coefficient and acoustic impedance were characterized by pulse echo ultrasound test at 5 MHz frequency and they are ranged from (1564 ± 88 to 1671 ± 124 m/s), (0.6915 ± 0.123 to 0.8268 ± 0.755 db cm-1 MHz-1) and (1.61×106 ± 0.127 to 1.76 × 106 ± 0.045 kg m-2 s-1) respectively. The elastic property Young’s Modulus of the prepared samples was measured by conducting quasi static uni axial compression test under a strain rate of 0.5 mm/min upto 10 % strain, and the values are from 50 kPa to 450 kPa for a variation of agar concentration from 1.7% to 6.6% by weight. The composite phantoms were imaged by Siemens Acuson S2000 (Siemens, Erlangen, Germany) machine using linear array transducer 9L4 at 8 MHz frequency; strain and displacement images were collected by UEI and ARFI. Shear wave velocity 4.43 ± 0.35 m/s was also measured for high modulus contrast (18 dB) inclusion and X.XX m/s was found for all other inclusions. The images were pre processed and parameters such as Contrast Transfer Efficiency and lateral image profile were computed and reported. The results indicate that both ARFI and UEI represent the abnormalities better than conventional US B mode imaging whereas UEI enhances the underlying modulus contrast into improved strain contrast. The results are corroborated with literature and also with clinical patient images. 相似文献
5.
Optical flow (OF) method has been used in ultrasound elastography to estimate the strain distribution in tissues. However the bias of strain estimation by OF has previously been shown to be close to 20%. The objective in this paper is to improve the performance of OF-based strain estimation, a two-step OF method with a local warping technique is proposed in this paper. The local warping technique effectively decreases the decorrelation of the signals, and hence improves the performance of strain estimation. Simulations on both homogeneous and heterogeneous models with different strains are performed. Experiments on a heterogeneous tissue-mimicking phantom are also carried out. Simulation results of the homogeneous model show that the two-step OF method reduces the bias of strain estimation from 23.77% to 1.65%, and reduces the standard deviation of strain estimation from 2.9 × 10−3 to 0.47 × 10−3. Simulation results of the heterogeneous model shows that the signals-to-noise ratio (SNRe) of strain estimation is improved by 2.1 and 5.3 dB in the inclusion and background, respectively, and the contrast-to-noise ratio (CNRe) is improved by 6.8 dB. Finally, results of phantom experiments show that, by using the proposed method, the SNRe is increased by 4.0 dB and 8.9 dB in the inclusion and background, respectively, while the CNRe is increased by 13.1 dB. The proposed two-step OF method is thus demonstrated capable of improving the performance of strain estimation in OF-based elastography. 相似文献
6.
Microscopic magnetic resonance elastography is a high-resolution method for visualizing shear waves and assessing the biomechanical viscoelastic properties of small biological samples. In this work, we used error propagation to develop a simple analytical model that relates the signal-to-noise ratio of MR magnitude images to the variance in shear-wave maps collected using gradient-echo and spin-echo phase-contrast pulse sequences. Our model predicts results for shear-wave images in phantoms, which match the experimentally observed phase variance within 8%. This model can be used to optimize MR pulse sequences for elastography studies, as well as other phase-difference techniques in MRI. 相似文献
7.
Identification of the anatomical location and mechanical properties such as adherence at the tissue tumour interface may be of clinical benefit in determination of tumour resectability and prognosis. There are currently no imaging modalities in routine clinical practice that can provide this information. This paper presents the development of a new imaging technique based on ultrasound elastography, called slip elastography, for determination of the anatomical location and measurement of the adherence between two surfaces. The theoretical basis of slip and its definition in relation to shear are described. In vitro testing with gelatine phantoms to determine the optimal parameters for shear strain estimation and slip boundary measurement and to test reliability are also described.The results suggest that slip elastography can reliably identify the anatomical location of a slip boundary and can measure the externally applied axial force required to initiate slip at that boundary in vitro. The vector based shear strain estimator was the most robust and worked with minimal angular dependence with minimal non-slip shearing artefact. 相似文献
8.
Elastography is a bioelasticity-based imaging modality which has been proved to be a potential evaluation tool to detect the tissue abnormalities. Conventional method for elastography is to estimate the displacement based on cross-correlation technique firstly, then strain profile is calculated as the gradient of the displacement. The main problem of this method arises from the fact that the cross-correlation between pre- and post-compression signals will be decreased because of the signal’s compression-to-deformation. It may constrain the estimation of the displacement. Numerical optimization, as an efficient tool to estimate the non-rigid deformation in image registration, has its potential to achieve the elastogram. This paper incorporates the idea of image registration into elastography and proposes a radio frenquency (RF) signal registration strain estimator based on the minimization of a cost function using numerical optimization method with Powell algorithm (NOMPA). To evaluate the proposed scheme, the simulation data with a hard inclusion embedded in the homogeneous background is produced for analysis. NOMPA can obtain the displacement profiles and strain profiles simultaneously. When compared with the cross-correlation based method, NOMPA presents better signal-to-noise ratio (SNR, 32.6 ± 1.5 dB vs. 23.8 ± 1.1 dB) and contrast-to-noise ratio (CNR, 28.8 ± 1.8 dB vs. 21.7 ± 0.9 dB) in axial normal strain estimation. The in vitro experiment of porcine liver with ethanol-induced lesion is also studied. The statistic results of SNR and CNR indicate that strain profiles by NOMPA performs better anti-noise and target detectability than that by cross-correlation based method. Though NOMPA carry a heavier computational burden than cross-correlation based method, it may be an useful method to obtain 2D strains in elastography. 相似文献
9.
Cardiac elastography using radiofrequency echo signals can provide improved 2D strain information compared to B-mode image data, provided data are acquired at sufficient frame rates. In this paper, we evaluate ultrasound frame rate requirements for unbiased and robust estimation of tissue displacements and strain. Both tissue-mimicking phantoms under cyclic compressions at rates that mimic the contractions of the heart and in vivo results are presented. Sinusoidal compressions were applied to the phantom at frequencies ranging from 0.5 to 3.5 cycles/sec, with a maximum deformation of 5% of the phantom height. Local displacements and strains were estimated using both a two-step one-dimensional and hybrid two-dimensional cross-correlation method. Accuracy and repeatability of local strains were assessed as a function of the ultrasound frame rate based on signal-to-noise ratio values.The maximum signal-to-noise ratio obtained in a uniformly elastic phantom is 20 dB for both a 1.26 Hz and a 2 Hz compression frequency when the radiofrequency echo acquisition is at least 12 Hz and 20 Hz respectively. However, for compression frequencies of 2.8 Hz and 4 Hz the maximum signal-to-noise ratio obtained is around 16 dB even for a 40 Hz frame rate. Our results indicate that unbiased estimation of displacements and strain require ultrasound frame rates greater than ten times the compression frequency, although a frame rate of about two times the compression frequency is sufficient to estimate the compression frequency imparted to the tissue-mimicking phantom. In vivo results derived from short-axis views of the heart acquired from normal human volunteers also demonstrate this frame rate requirement for elastography. 相似文献
10.
We study displacement and strain measurement error of dual transducers (two linear arrays, aligned orthogonally and coplanar). Displacements along the beam of each transducer are used to obtain measurements in two-dimensions. Simulations (5 MHz) and experiments (10 MHz) are compared to measurements with a single linear array, with and without angular compounding. Translation simulations demonstrate factors of 1.07 larger and 8.0 smaller biases in the axial and lateral directions respectively, for dual transducers compared to angular compounding. As the angle between dual transducers decreases from 90° to 40°, for 1% compression simulations, the lateral RMS error ranges from 2.1 to 3.9 μm compared to 9 μm with angular compounding. Simulation of dual transducer misalignment of 1 mm and 2° result in errors of less than 9 μm. Experiments demonstrate factors of 3.0 and 5.2 lower biases for dual transducers in the axial and lateral directions respectively compared to angular compounding. 相似文献