氯·氨荒酸基·二苯基锗配合物的合成

以二苯基二氯化锡和氨荒酸盐为原料,合成了13种氯．氨荒酸基．二苯基锗配合物,利用元素分析,IR和1HNMR表征了这些配合物的结构,生物活性测试结果表明,该类化合物对KB和Bel癌细胞具有较好的抑制活性。     

三苯基锗氨荒酸酯的合成

合成了10个新的三苯基锗氨荒酸酯类化合物,利用元素分析,IR、^1HNMRMS表征了它们的结构。部分化合物初步生物活性测试结果表明,该类化合物对KB,HCT和Bel癌细胞具有较好的抑制活性。     

三苯基锡（IV）哌啶氨荒酸酯的合成及结构研究

利用三苯基氯化锡和哌啶氨荒酸钠反应，合成了三苯基锡(IV)哌啶氨荒酸酯。通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征。用X-射线单晶衍射测定了该化合物的晶体结构。结果表明，化合物中锡原子呈五配位畸变三角双锥构型。     

二苄基一氯化锡氨荒酸酯的合成与表征

合成了13个新的二苄基氯化锡氨荒酸酯化合物(PhCH_2)_2Sn(Cl)S_2CNRR＇。利用元素分析、UV.IR.H NMR谱和TG-DTA表征了它们的结构 初步生物活性研究表明,有些化合物表现出体外抑制白细胞P_(388)生长的活性。     

三苯基锡(Ⅳ)哌啶氨荒酸酯的合成及结构研究

利用三苯基氯化锡和哌啶氨荒酸钠反应,合成了三苯基锡(Ⅳ)哌啶氨荒酸酯.通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征.用X-射线单晶衍射测定了该化合物的晶体结构.结果表明,化合物中锡原子呈五配位畸变三角双锥构型.     

氨荒酸膦酸树脂的合成及应用.Ⅰ.树脂的合成

本文以丙烯酸甲酯为原料,经过聚合,胺化,磷化,氨荒酸化等反应,合成了氨荒酸膦酸螯合树脂,探讨了影响各步功能基化反应的反应条件。     

二苄基锡双氨荒酸酯的合成

由二苄基二氯化锡与氨荒酸盐反应，合成了１０个新的二苄基锡双氨荒酯化合物，利用元素分析，ＩＲ和＾１ＮＮＭＲ表征了这些化合物的结构。     

氨荒酸膦酸树脂的合成及应用.Ⅱ.树脂的应用

本文以原子吸收光谱为检测手段,将氨荒酸膦酸树脂应用于地下水中Zn,Cd,Co,Cr,Cu,Mn,Ni,Pb等八种痕量元素的同时分析,取得了满意的结果。用美国环保局标准水样评价此分析方法的可靠性,结果表明分析结果的方差小,回收率高。文中还探讨了氨荒酸膦酸树脂对Hg~(2+)的吸附性能和吸附机理,表明树脂吸附Hg~(2+)的过程是受内扩散控制的。     

二苄基一氯化锡氨荒酸酯的合成与表征

合成了13个新的二苄基一氯化锡氨荒酸酯化合物(PhCH~2)~2Sn(Cl)Sn(Cl)S~2CNRR'。利用元素分析、UV、IR、^1HNMR谱和TG-DTA表征了它们的结构。初步生物活性研究表明,有些化合物表现出体外抑制白血细胞P~3~8~8生长的活性。     

氯·氨荒酸基·二丁基锡(Ⅳ)配合物的合成和性质

合成了 13种新的氯·氨荒酸基·二丁基锡 ?配合物 (n C4H9)2Sn(C1)S2CNRR′。通过元素分析、 IR、 UV、 1H NMR及 MS对这些配合物进行了表征,结果表明,氨荒酸基是以双齿形式与锡原子配位。初步生物活性测试表明,部分配合物具有较强的抗癌活性。     

三丁基锡二硫代氨基甲酸酯的合成及表征

通过三丁基氯化锡与二硫代氨基甲酸盐反应,合成了１０个 三丁基锡二硫代氨基甲酸酯,利用元素分析,ＩＲ、ＨＮＭＲ、ＵＶ和ＴＧ－ＤＴＡ表征了这些化合物结构,测定了部分化合物的生物活性。     

Carbazyl RAFT agents synthesized by an improved aqueous phase method and their applications in RAFT polymerization

A series of carbazyl dithiocarbamates as RAFT agents, i.e. benzyl 9H-carbazole-9-carbodithioate (B), 1-phenylethyl 9H-carbazole-9-carbodithioate (C), cumyl 9H-carbazole-9-carbodithioate (D) and tert-butyl 9H-carbazole-9-carbodithioate (E), were successfully synthesized by an improved aqueous phase method based on a nucleophilic substitution reaction between sodium carbazole-9-carbodithioate (A) and alkyl halides at room temperature. Furthermore, the optimum reaction conditions and synthetic technology were sought. Compared with the traditional oil-phase method, the expected high-purity RAFT agents were obtained in the form of crystal that was precipitated and separated from the aqueous solution, so that vast organic solvents for purification were avoided. The activities of the carbazyl dithiocarbamates obtained as RAFT agents for the polymerizations of both styrene and methyl methacrylate were determined. The results show that all of the RAFT agents above mentioned are of significant activity in the RAFT polymerization of styrene, but only D has obvious activity in the RAFT polymerization of methyl methacrylate. Therefore, both the novel synthetic method and the carbazyl dithiocarbamates obtained possess potential application in the RAFT polymerization.     

Influence of the chemical structure of dithiocarbamates with different N‐groups on the reversible addition–fragmentation chain transfer polymerization of styrene

Polymerizations of styrene with azobisisobutyronitrile initiation or thermal initiation have been performed in the presence of dithiocarbamates with different N‐groups, that is, benzyl 4,5‐diphenyl‐1H‐imidazole‐1‐carbodithioate ( 2a ), benzyl 1H‐1,2,4‐triazole‐1‐carbodithioate ( 2b ), benzyl indole‐1‐carbodithioate ( 2c ), benzyl 2‐phenyl‐indole‐1‐carbodithioate ( 2d ), benzyl phenothiazine‐10‐carbodithioate ( 2e ), benzyl 9H‐carbazole‐9‐carbodithioate ( 2f ), and benzyl dibenzo[b,f]azepine‐5‐carbodithioate ( 2g ). The results show that the structure of the N‐group of dithiocarbamates has significant effects on the activity of dithiocarbamates for the polymerization of styrene. 2a , 2b , 2c , 2d , and 2f are effective reversible addition–fragmentation chain transfer (RAFT) agents for the RAFT polymerization of styrene, and the polymerizations have good living characteristics. However, in the cases of 2e and 2g , the obtained polymers have uncontrolled molecular weights and broad molecular weight distributions. The polymerization rate is markedly influenced by the conjugation structure of the N‐group of the dithiocarbamate, and the polymerization rate of 2b is greater than that of 2a . For 2b , the rate of polymerization seems independent of the RAFT agent concentration. However, a significant retardation in the rate of polymerization can be observed in the case of 2c . 2d is more effective than 2c , and the substitution group of phenyl on this dithiocarbamate has obvious effects on the effectiveness of the controlled polymerization of styrene. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 4849–4856, 2005     

二苯基锗二硫代氨基甲酸酯的合成及表征

合成了10种二苯基锗二硫代氨基甲酸酯Ph2Ge(S2CNR2)2,用元素分析、IR、^1H NMR和MS表征了这些化合物的结构,体外实验表明,这些化合物对MCF－7,WiDr和EC癌细胞具有较的抑制活性。     

三苯基锗二硫代氨基甲酸酯的合成及表征

近年来 ,人们相继合成了有机锗倍半硫化物、有机锗硫杂环戊酮、含硫的螺环有机锗等化合Scheme1　 Synthetic route of compound物[1,2 ] .但烃基锗二硫代氨基甲酸酯类化合物尚未见报道 .我们 [3,4 ] 发现 ,有机锡二硫代氨基甲酸酯类化合物有很强的生物活性 .鉴于有机锗化合物比有机锡化合物毒性低得多 ,且副作用小 ,我们以三苯基氯化锗和二硫代氨基甲酸盐为原料 ,合成了一系列新型的有机锗含硫衍生物 (反应式如Scheme1所示 ) ,并对其结构进行了表征 ,初步生物活性测试结果表明 ,部分化合物显示出较强的抗癌活性 .1　实　　验1 .1　仪器与…     

Determination of N,N-Dialkyl Dithiocarbamates in Wastewater by Thin-Layer Densitometry

Abstract

The quantitative determination of N,N-dialkyl dithiocarbamates tetramethylthiuram disulfide and tetramethyl-thiuram monosulfide in industrial wastewater was studied by thin-layer densitometry of their copper complexes. It has been demonstrated that a densitometer provides a simple and rapid means to quantitate these compounds. N,N-dialkyl dithiocarbamates have been analyzed in microgram quantities using this method. Coefficients of variation of 2–6 per cent were obtained.     

新双硫代甲酸盐衍生物的合成

双硫代甲酸盐可用作抗菌剂,橡胶硫氏剂,也是过渡金属的良好配位体。但是大多数研究都只限于脂肪族一元胺衍生物,本文报道芳香族及脂肪族多元胺的双硫代甲酸盐的合成。产物的红外光谱,核磁共振谱和元素分析结果列于附表。