共查询到20条相似文献,搜索用时 375 毫秒
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本实验中,将2,2'-联苯二酚与1-溴丁烷经Williamson反应后,利用该反应产物溴化钠在酸性条件下与溴酸钠反应生成初生态的溴作为溴源,溴代反应得到5,5'-二溴-2,2'-二丁氧基联苯.中间产物5,5'-二溴-2,2'-二丁氧基联苯制成Grignard试剂后与烯丙基溴反应生成5,5'-二烯丙基-2,2'-二丁氧基... 相似文献
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烯丙基溴与金属钐在室温条件下、THF溶剂中反应生成中间体烯丙基溴化钐,烯丙基溴化钐再与α,β-不饱和醛、酮反应生成高烯丙基醇.烯丙基溴化钐与α,β-不饱和醛、酮发生1,2-加成反应,其与α,β-不饱和酮的反应几乎定量进行,表明该反应具有很好的区域选择性.产物的结构通过IR,1H NMR和MS光谱确证. 相似文献
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利用氢氧化钠作催化剂使β-环糊精(简称β-CD)被烯丙基修饰合成了七-(2,3,6-O-烯丙基)-β-环糊精[Heptakis-(2,3,6-O-allyl)-β-CD].用正交实验法考察了反应温度、反应时间、催化剂用量和修饰剂--烯丙基溴用量等因素对合成目标化合物的影响,得出合成七-(2,3,6-O-烯丙基)-β-环糊精的最佳实验条件:n(β-环糊精)∶n(烯丙基溴)=1∶86.92,n(催化剂)∶n(烯丙基溴)=1∶1.052.产物经元素分析,IR和1H NMR表征和确认. 相似文献
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Stable enolates such as diethyl malonate enolate can be smoothly substituted by allylic acetates (or sulfones) in the presence of nickel complexes. Sulfinate ions convert allylic acetates into sulfones. 相似文献
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XS Wu Y Chen MB Li MG Zhou SK Tian 《Journal of the American Chemical Society》2012,134(36):14694-14697
The NH(2) group in primary allylic amines was substituted directly by sulfinate salts with excellent regio- and stereoselectivities. In the presence of 0.1 mol % [Pd(allyl)Cl](2), 0.4 mol % 1,4-bis(diphenylphosphino)butane (dppb), and excess boric acid, a range of α-unbranched primary allylic amines were smoothly substituted with sodium sulfinates in an α-selective fashion to give structurally diverse allylic sulfones in good to excellent yields with exclusive E selectivity. Replacing dppb with 1,1'-bi-2-naphthol (BINOL) allowed unsymmetric α-chiral primary allylic amines to be transformed into the corresponding allylic sulfones in good to excellent yields with excellent retention of ee. Importantly, the reaction complements known asymmetric methods in substrate scope via its unique ability to provide α-chiral allylic sulfones with high optical purity starting from unsymmetric allylic electrophiles. 相似文献
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Rhodium‐Catalyzed Highly Regio‐ and Enantioselective Hydrogenation of Tetrasubstituted Allenyl Sulfones: An Efficient Access to Chiral Allylic Sulfones 下载免费PDF全文
Jiao Long Liyang Shi Xiong Li Prof. Hui Lv Prof. Xumu Zhang 《Angewandte Chemie (International ed. in English)》2018,57(40):13248-13251
A highly regio‐ and enantioselective hydrogenation of challenging tetrasubstituted allenyl sulfones has been developed, affording chiral allylic sulfones in good yields with excellent regio‐ and enantioselectivities (up to 99 % yield and 99 % ee). This method provides an efficient and concise route to chiral allylic sulfones, thus offering an atom‐economic process with a wide range of potential applications in organic synthesis and medicinal chemistry. 相似文献
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The alkylation of conjugated arylsulfonyl ylids, prepared from the corresponding allylic sulfones (2 or 8), and allylic halides bearing terminal carbonylgroups (3 or 4) leads to polyene sulfones which readily undergo spontaneous elimination of the corresponding aryl sulfinates. By this method two apocarotenoids (5 and 6) and torularhodin ethyl ester (9) have been prepared. 相似文献
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Samuel Braverman Dan Grinstein Zvi Lior 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):443-444
Abstract The synthesis and rearrangement of the title compounds to sulfones are discussed. A facile isomerization of the allylic trichloromethyl sulfones to the corresponding vinyl sulfones is also described. 相似文献
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Aijie Cai Arjan W. Kleij 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(42):15086-15091
We describe here the first general asymmetric synthesis of sterically encumbered α,α‐disubstituted allylic sulfones via Pd‐catalyzed allylic substitution. The design and application of a new and highly efficient phosphoramidite ligand ( L10 ) proved to be crucial, and a wide variety of challenging allylic sulfones featuring quaternary stereocenters could be obtained in good yields and with good to excellent levels of regio‐ and enantioselectivities under attractive process conditions. The developed methodology employs easily accessible chemical feedstock including racemic allylic precursors and sodium sulfinates. The utility of the method is further demonstrated by the synthesis of the sesquiterpene (?)‐Agelasidine A. 相似文献
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Allyl sulfones are versatile intermediates in organic chemistry. The presence of two distinct functional groups sets the stage for a plethora of subsequent transformations. However, despite these advantages the preparation of regioisomerically enriched sulfones is not easy. The use of sulfinate salts as nucleophiles in substitutions is frequently accompanied by side reactions such as π-bond migration, β-elimination, and so on. Herein we present a preparatively simple way to synthesize a variety of different aryl or alkyl allyl sulfones starting from readily accessible allylic carbonates. By employing aryl or alkyl α-sulfonyl succinimides as sulfinate synthons, mild and regioselective ipso substitution of diverse allylic carbonates was realized. 相似文献
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Allylic tri-n-butyltins can be prepared easily by the treatment of allylic sulfones or sulfides with tri-n-butyltin formate in refluxing xylene. 相似文献
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Lithium salts of allylic sulfones are oxidized with ferric chloride-dimethyl-formamide complex mainly to 1,6-disulfones by 3-3′ coupling. Products resulting from coupling of 3,3-disubstituted sulfones undergo Cope rearrangement affording vicinal disulfones with threo-configuration. Coupling with iodine results in mixtures containing mainly vicinal disulfones, again with threo-configuration. 相似文献
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A highly chemoselective oxidation of widely substituted aryl allylic sulfides, prepared by allylation of arylthioethers with KF-Celite, to the corresponding aryl allylic sulfoxide was achieved by employing calcium hypobromite. Neither over-oxidation to sulfones nor halogenation of the aromatic rings was observed. The protocol may be successfully applied for the oxidation of substituted allylic systems (i.e., 2-haloallyl) that per se could interact with the oxidizing agent. 相似文献