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Rhodium‐Catalyzed Highly Regio‐ and Enantioselective Hydrogenation of Tetrasubstituted Allenyl Sulfones: An Efficient Access to Chiral Allylic Sulfones |
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| Authors: | Jiao Long Liyang Shi Xiong Li Prof Hui Lv Prof Xumu Zhang |
| Institution: | 1. Key Laboratory of Biomedical Polymers of Ministry of Education &, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, P. R. China;2. Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, P. R. China;3. Department of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen, Guangdong, P. R. China |
| Abstract: | A highly regio‐ and enantioselective hydrogenation of challenging tetrasubstituted allenyl sulfones has been developed, affording chiral allylic sulfones in good yields with excellent regio‐ and enantioselectivities (up to 99 % yield and 99 % ee). This method provides an efficient and concise route to chiral allylic sulfones, thus offering an atom‐economic process with a wide range of potential applications in organic synthesis and medicinal chemistry. |
| Keywords: | allenes allylic sulfone asymmetric hydrogenation enantioselectivity rhodium |