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交让木(Daphniphyllum macropodum)和虎皮楠(Daphniphyllum angustifolium)属于虎皮楠科虎皮楠属,为小乔木.近年来,从虎皮楠属植物中分离得到一系列结构非常复杂的、独特的、生物活性多样的聚环生物碱[1,2],我们从交让木(D.macropodum)中分得7个此类生物碱,根据NMR和MS数据鉴定了3个化合物的结构,其中1个为新化合物.另外4个化合物的结构正在鉴定中.经文献查阅发现对该属植物非生物碱部分的研究很少,我们从虎皮楠)(D.angustifolium)非生物碱部位分得18个化合物,并根据NMR,UV,和MS等数据鉴定了它们的结构,其中7个为新化合物.新化合物的结构如下所示: 相似文献
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本文报道从虎皮楠科植物交让木的树皮中分到4个新的和7个已知的虎皮楠生物碱的结构研究。4个新生物碱分别命名为脱氧交让木碱(dehydroxymacropodumineA)(1), 4,21-脱乙酰-23-脱甲基-脱氧交让木胺(4,21-deacetyl-23-demethyl-deoxyyuzurimine) (2),7-氧杂--脱氧交让木胺(7-oxo-deoxyyuzurimine)(3),和4-乙酰氧-虎皮楠素B (4-acetoxydaphmanidinB)(4)。新化合物1-4的结构是通过仔细解析其波谱数据和与已知结构相关的化合物波谱数据比较而确定。脱氧交让木碱(dehydroxymacropodumineA)(1) 具有罕见的11元环的大环内酯结构,是从自然界中分到的第二个具有这一新颖结构特征的生物碱。 相似文献
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生物碱类天然产物通常具有复杂多样的化学结构和广泛的生物活性,因此备受生物学、化学、药学领域研究者的关注。微生物是仅次于植物的生物碱类天然产物重要来源,微生物尤其是放线菌产生的众多次生代谢产物中,也包括很多生物碱。对放线菌来源生物碱的骨架结构和药效基团生物合成研究,不仅能够丰富人们对天然产物结构形成原理的理解,还可以为运用合成生物学技术人工合成此类化合物提供重要的遗传元件。本文从模块化生物合成和非模块化生物合成两种方式,综述放线菌来源生物碱的生物合成基因簇、途径及其酶催化反应过程。 相似文献
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二酮哌嗪类化合物(DKPs)的特征结构是由两个α-氨基酸通过肽键缩合而成的环二肽(CDPs),稳定的六元环骨架结构使DKPs在药物化学中成为一个重要的药效团,表现出丰富的生物活性.合成可作为药物先导物的DKPs已日益引起人们的关注,其中,开展生物合成研究是拓宽其化学结构多样性的一个有效途径.与早期阐明的非核糖体肽合成酶(NRPSs)生物合成途径不同,环二肽合酶(CDPSs)以氨酰-t RNAs(aa-t RNAs)作为底物合成环二肽,其后修饰过程发生在环二肽形成之后.目前国内外已研究的经CDPS途径合成的二酮哌嗪类化合物报道了6例.对近年来环二肽合酶(CDPSs)生物合成途径相关研究进展进行了综述. 相似文献
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单萜吲哚生物碱是一类具有重要药用价值的天然产物,但是在其宿主的生物含量很低;虽然通过有机化学的方法可以实现该类复杂结构化合物的全合成,但是难以大量快速获得,而且围绕核心骨架的进一步衍生化修饰也有一定的瓶颈.随着单萜吲哚生物碱生物合成途径的解析和合成生物学使能技术的发展,利用合成生物学策略结合化学半合成将是实现该类化合物的合成制造和通量结构衍生化的重要发展趋势.单萜吲哚生物碱基因元件的挖掘鉴定和生物合成途径的解析是进行合成生物学研究的前提条件.异胡豆苷是单萜吲哚生物碱合成的关键骨架化合物,由色胺和开环马钱子苷汇聚合成,这一过程被称为上游合成途径;以异胡豆苷为骨架形成各种单萜吲哚生物碱的过程称为下游合成途径.从这两个方面对近30年来单萜吲哚生物碱合成元件的发现和合成生物学研究进展进行了综述,为后续合成生物学的应用研究奠定基础. 相似文献
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中国番荔枝科植物抗癌有效成分研究 总被引:6,自引:0,他引:6
介绍了近年来我们实验室中国番荔枝科植物抗癌有效成分研究工作。从番荔枝科5种紫玉盘属植物,5种哥纳香属植物,1种番荔枝属植物,1种囊瓣木属植物中分离得到59种新的番荔枝内酯,32种新的多氧取代环己烯,12种新的苯乙烯吡喃酮和3种新的生物碱,并通过化学和光谱方法鉴定了它们的结构。大部分化合物显示了较强的抗癌活性。并对抗癌活性成分海南哥纳香醇甲进行了全合成。 相似文献
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J I Kobayashi Y Inaba M Shiro N Yoshida H Morita 《Journal of the American Chemical Society》2001,123(46):11402-11408
Eight highly modified Daphniphyllum alkaloids with unprecedented fused hexa- or pentacyclic skeletons, daphnicyclidins A-H (1-8), have been isolated from the stems of Daphniphyllum humile and D.teijsmanni, and their structures were elucidated on the basis of spectroscopic data and chemical means. The stereochemistry was elucidated by combination of NOESY correlations, X-ray crystallographic data, and CD analyses. 相似文献
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Two Daphniphyllum alkaloids with unprecedented polycyclic skeletons, daphnicyclidins J (1) and K (2), have been isolated from the stems of Daphniphyllum humile, and the structures and relative stereochemistry were elucidated on the basis of spectroscopic data. The absolute stereochemistry of 1 was established by chemical correlation with a known-related alkaloid, daphnicyclidin D (3), through a modified Polonovski reaction. 相似文献
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[structure: see text] Two new complex polycyclic alkaloids, macropodumines D (1) and E (2), both possessing unprecedented skeletons, along with four known related alkaloids, were isolated from the leaves and barks of Daphniphyllum macropodum Miq. The structures including the relative stereochemistry of new compounds 1 and 2 were elucidated on the basis of detailed spectroscopic data analysis. 相似文献
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Two new alkaloids, angustimine (1) featuring an unprecedented skeleton, and angustifolimine (2) being a rare diamino Daphniphyllum alkaloid, were isolated from Daphniphyllum angustifolium. Their structures were elucidated by extensive spectroscopic analysis. The biosynthetic origin of 1 was postulated. Cytotoxic activities of 1 and 2 were tested, and all of them were inactive. 相似文献
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Liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (LC/ESI-QTOF-MS/MS) was performed to study the fragmentation behaviors of steroidal alkaloids from Fritillaria species, the antitussive and expectorant herbs widely used in traditional Chinese medicine. We propose, herein, a strategy that combining key diagnostic fragment ions and the relative abundances and amounts of major fragment ions (the ions exceeding 10% in abundance) to distinguish different sub-classes of Fritillaria alkaloids (FAs). It was found that hydrogen rearrangement and induction effects result in ring cleavage of the basic skeletons occurred in the MS/MS process and produced characteristic fragment ions, which are useful for structural elucidation. This method was finally used to investigate the primary steroidal alkaloids in the extracts of eight major Fritillaria species. As a result, 41 steroidal alkaloids (29 cevanine type, 1 jervine type, 6 veratramine type and 5 secosolanidine type alkaloids) were selectively identified in these Fritillaria species. Twenty-six compounds were unambiguously identified by comparing with the reference compounds and 15 compounds were tentatively identified or deduced according to their MS/MS data. Logical fragmentation pathways for different types of FAs have been proposed and are useful for the identification of these types of steroidal alkaloids in natural products especially when there are no reference compounds available. 相似文献
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[structure: see text] Two types of Daphniphyllum alkaloids with unprecedented fused-hexacyclic ring systems, calyciphyllines A (1) and B (2), have been isolated from the leaves of Daphniphyllum calycinum (Daphniphyllaceae), and the structures and relative stereochemistry were elucidated on the basis of spectroscopic data. 相似文献
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[structure: see text] Two cytotoxic quaternary Daphniphyllum alkaloids with an unprecedented fused-polycyclic skeleton containing a 1-azoniatetracyclo[5.2.2.0.(1,6)0.(4,9)]undecane ring system, daphniglaucins A (1) and B (2), have been isolated from the leaves of Daphniphyllum glaucescens. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic data. 相似文献
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Yu Zhang Ying‐Tong Di Hai‐Yang Liu Chun‐Shun Li Cheng‐Jian Tan Qiang Zhang Xin Fang Shun‐Lin Li Xiao‐Jiang Hao 《Helvetica chimica acta》2008,91(11):2153-2158
Nine Daphniphyllum alkaloids, including three new ones, paxiphyllines C–E ( 1 – 3 , resp.), were isolated from the twigs and the leaves of Daphniphyllum paxianum. Paxiphylline C ( 1 ) represents the first example of Daphniphyllum alkaloids with a carbonyldioxy group. Their structures were elucidated on the basis of spectroscopic data. 相似文献
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Qiang Zhang Ying‐Tong Di Hai‐Yang Liu Ning‐Chuan Kong Suo Gao Chun‐Shun Li Yu Zhang Shun‐Lin Li Xiao‐Jiang Hao 《Helvetica chimica acta》2008,91(5):914-919
Two new yuzurine alkaloids, daphnoldines A ( 1 ) and B ( 2 ), possessing a rare four‐ring system, were isolated from the fruits of Daphniphyllum oldhami. Their structures were established on the basis of extensive spectroscopic analyses. Daphnoldine A ( 1 ) is the first example of Daphniphyllum alkaloids bearing a hydroxymethyl group at C(14). 相似文献
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Li‐She Gan Xiao‐Ning Wang Cheng‐Qi Fan Yan Wu Jian‐Min Yue 《Helvetica chimica acta》2007,90(12):2395-2400
Seventeen Daphniphyllum alkaloids, including two new pentacyclic alkaloids, yuzuric acid ( 1 ) and daphnezomic acid ( 2 ), and 15 known ones, were isolated from the fruits of Daphniphyllum oldhamii. The structures and configuration of the two new alkaloids were determined on the basis of spectroscopic methods, especially 2D NMR techniques. 相似文献