共查询到20条相似文献,搜索用时 93 毫秒
1.
2.
3-芳基-6-(6-/8-取代-4-氯喹啉-3-基)1,2,4-三唑-[3,4-b]-1,3,4-噻二唑类化合物的合成 总被引:2,自引:0,他引:2
研究了3-芳基-4-氨基-5-巯基-1,2,4-三唑与6-/8-取代-4-羟基喹啉-3-酸在三氯氧磷催化下的反应,制得16个的3-芳基-6-(6-/8-取代-4-氯喹啉-3-基)1,2-4,-三唑[3,4-b)-1,3,4-噻二唑,新化合物的结构通过元素分析,IR,^1H NMR和MS确定,讨论了其波谱性质。 相似文献
3.
4.
5.
6.
1-取代苯基-1,4-二氢-6-甲基-4-哒嗪酮-3-酰氨基硫脲的合成及其抗烟草花叶病毒活性 总被引:8,自引:0,他引:8
用1-芳基-1,4-二氢-6-甲基-4-氧哒嗪-3-酰肼与取代苯基异硫氰酸酯反应合成了系列新型取代-1,4-二氢-6-甲基-4-哒嗪酮-3-酰氨基硫脲化合物,其结构经IR,1H NMR及元素分析确认,生物活性测定表明,该类化合物对烟草花叶病毒具有很高的抑制活性。 相似文献
7.
8.
本文以2-氰基-4-硝基-6-溴苯胺为原料,经重氮化后与邻异丙基苯酚偶联,合成2-(2-氰基-4-硝基-6-溴苯偶氮)-6-异丙基苯酚,用乙醇重结晶精制。用元素分析,波谱等鉴定其结构,并测定其离解常数,研究该试剂的一般性质。发现其与Cu2+、Ni2+、Co2+等的显色反应在吐温80表面活性剂存在下有较高的灵敏度。 相似文献
9.
10.
应用反相高效液相色谱法,分离和鉴定3,4,6,7,9,10-6H-3,3,6,6-四甲基-9-对硝基苯基吖啶-1,8-二酮(化合物Ⅰ),分离系统包括Zorbax SB C18及苯基柱,紫外检测器检测波长为285nm,等比和线性梯度淋洗,液相色谱-质谱联用和光导二极和列检测系统被用来鉴定主要化合物及其它杂质,此方法可达到分离效果好,灵敏度高。 相似文献
11.
Various pyrazole and dihydropyrazolones containing an adamantane fragment were synthesized from adamantyl-substituted 1,3-
and 1,4-diketones, ethyl 4-(1-adamantyl)-2-R-4-oxobutanoates (R = CN, Ac), and ethyl 2-(1-adamantylcarbonyl)-4-oxo-4-phenylbutanoate. 相似文献
12.
《Tetrahedron: Asymmetry》1999,10(12):2327-2336
Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate, a key component of the natural product bestatin and HIV protease inhibitors of KNI-272 and R-87366, has been achieved from the stereoselective aldimine coupling reaction between 3-phenyl-2-aminopropanenitrile and (Z)-α-methoxy trimethylsilyl ketene acetal in the presence of Lewis acids. 相似文献
13.
V. L. Gein N. N. Kasimova Z. G. Aliev M. I. Vakhrin 《Russian Journal of Organic Chemistry》2010,46(6):875-883
The reactions of methyl 2,4-dioxo-4-phenylbutanoate and methyl 2,4-dioxopentanoate with a mixture of an aromatic aldehyde
and propane-1,2-diamine, depending on the initial reactant ratio, gave 4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-2,5-dihydro-1H-pyrrol-2-ones and 1,1′-(propane-1,2-diyl)bis(4-acetyl-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one). Reactions of substituted 1-(2-aminopropyl)-2,5-dihydro-1H-pyrrol-2-ones with aromatic amines and hydrazines were studied, and the structure of one of the products, 5-(2-aminopropyl)-3,4-diphenylpyrrolo[3,4-c]pyrazol-6-one, was proved by X-ray analysis. 相似文献
14.
Kusano G Orihara S Tsukamoto D Shibano M Coskun M Guvenc A Erdurak CS 《Chemical & pharmaceutical bulletin》2002,50(2):185-192
Investigation of the constituents of the fruits of Morus alba LINNE (Moraceae) afforded five new nortropane alkaloids (1-5) along with nor-psi-tropine (6) and six new amino acids, morusimic acids A-F (7-12). The structures of the new compounds were determined to be 2alpha,3beta-dihydroxynortropane (1), 2beta,3beta-dihydroxynortropane (2), 2alpha,3beta,6exo-trihydroxynortropane (3), 2alpha,3beta,4alpha-rihydroxynortropane (4), 3beta,6exo-dihydroxynortropane (5), (3R)-3-hydroxy-12-[(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yll-dodecanoic acid-3-O-beta-D-glucopyranoside (7), (3R)-3-hydroxy-12-[(1S,4S)-4-[(1S)-1-hydroxyethyl]-pyrrolidin-1-yll-dodecanoic acid (8), (3R)-3-hydroxy-12-1(1R,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yll-dodecanoic acid-3-O-beta-D-glucopyranoside (9), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-methyl-piperidin-1-yll-dodecanoic acid (10), (3R)-3-hydroxy-12-[(1R,4R,5S)-4-hydroxy-5-hydroxymethyl-piperidin-1-yl]-dodecanoic acid-3-O-beta-D-glucopyranoside (11), and (3R)-3-hydroxy-12-[(1R,4S,5S)-4-hydroxy-5-methyl-piperidin-1-yl]-dodecanoic acid (12) on the basis of spectral and chemical data. 相似文献
15.
We have developed the chloramphenicol base urea-catalyzed intramolecular Michael addition of γ-hydroxy-α, β-unsaturated enones. The oxidation of the resulting products provided facile access to the corresponding α-hydroxy chiral alcohols with good efficiency and enantioselectivity, with the reaction displaying broad substrate scope. The utility of this methodology was further demonstrated by the synthesis of (R)-2-hydroxy-4-phenylbutanoate, which is a key building block for the construction of the ACE inhibitor benazepril hydrochloride. 相似文献
16.
Shibano M Tsukamoto D Fujimoto R Masui Y Sugimoto H Kusano G 《Chemical & pharmaceutical bulletin》2000,48(9):1281-1285
Four new pyrrolidine alkaloids, broussonetines M, O, P, and Q, were isolated from the branches of Broussonetia kazinoki SIEB, (Moraceae). Broussonetines M, O, P, and Q were formulated as (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(10S)-10,13-dihydroxy-tri decyl]pyrrolidine (1), (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(E)9-oxo-13-hydroxy-3- tridecenyl]pyrrolidine (2), (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(E)10-oxo-13-hydroxy-3-++ +tridecenyl]pyrrolidine (3), and (2R,3S,4R,5R)-2-hydroxymethyl-3-hydroxy-4-(beta-D-glucopyranosyloxy++ +)-5-[10-oxo-13-(beta-D-glucopyranosyloxy)tridecyl]pyrrolidine (4) respectively, by spectroscopic and chemical methods. 1-4 inhibited beta-glucosidase, beta-galactosidase and beta-mannosidase. 相似文献
17.
Ma G Li W Dou D Chang X Bai H Satou T Li J Sun D Kang T Nikaido T Koike K 《Chemical & pharmaceutical bulletin》2006,54(8):1229-1233
Five new monoterpene glycosides, rhodiolosides A-E (1-5), were isolated from the roots of Rhodiola rosea (Crassulaceae). Their structures were elucidated as (2E,6E,4R)-4,8-dihydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glucopyranoside (1), (2E,4R)-4-hydroxy-3,7-dimethyl-2,6-octadienyl alpha-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside (2), (2E,4R)-4-hydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glucopyranosyl(1-->3)-beta-D-glucopyranoside (3), (2E,4R)-4,7-dihydroxy-3,7-dimethyl-2-octenyl beta-D-glucopyranoside (4), and (2E)-7-hydroxy-3,7-dimethyl-2-octenyl alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside (5), on the basis of various spectroscopic analyses and chemical degradation. 相似文献
18.
Ethyl 2-oxo-4-aryl-3-butene-1-oates 1a–1c are reduced by NAD(P)H models (1-n-propyl-1,4-dihydronicotinamide (4) and Hantzsch ester(5)), in presence of magnesium perchlorate. One equivalent of the reductant reduces the substrates selectively to the corresponding 2-oxo-4-arylbutanoates (6,10a,b). An additional equivalent and higher temperature, converts ethyl 2-oxo-4-phenylbutanoate (6) to ethyl 2-hydroxy-4-phenylbutanoate (7). Reduction of ethyl 2-oxo-4-phenyl-3-buten-1-oate (1a) by Hantzsch ester in C2H5OD or by Hantzsch ester-4,4-d2 in C2H5OH, leads to direct transfer of the hydrogen or deuterium, respectively, without isotopic scrambling. These results have been interpreted to support the hydride transfer mechanism. 相似文献
19.
Xi Ying ZHAO Machiko ONO Hiroyuki AKITA Yu Ming CHI 《中国化学快报》2006,17(6):727-729
( )-(4S,5R)-Osmundalactone 1 was isolated from the fungus Paxillus atrotomentosus (Paxillaceae) by Buchanan1. (-)-(4R,5S)-Osmundalactone 1 and ( )-(4R,5S)-5-hydroxy- 2-hexen-4-olide 2 were isolated from Osmunda japonica (Osmundaceae) as feeding inhibitors… 相似文献
20.
Isaka K Nagatsu A Ondognii P Zevgeegiin O Gombosurengyin P Davgiin K Kojima K Ogihara Y 《Chemical & pharmaceutical bulletin》2001,49(9):1072-1076
Nine novel prenyl-dihydrofurocoumarin-type sesquiterpenoid derivatives, 2,3-dihydro-7-hydroxy-2R*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadien-6-onyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2R*,3R*-dimethyl-2-[4-methyl-5- (4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2R*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadien-6-onyl]-furo-[3,2-c]coumarin, and 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, were isolated from the roots of Ferula ferulaeoides [corrected]. The structures were established by comprehensive spectral analysis. The biosynthetic pathway leading to these prenyl-furocoumarin-type sesquiterpenoids is proposed based on their structures. 相似文献