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N;N'-二(糖基硫代亚脲基)芳基硫代膦酰二胺的合成;糖基异硫氰酸酯;硫代膦酰二肼;生物活性 相似文献
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在众多桥联配体中 ,二硫代草酰胺有独特的性质 ,其衍生物与各种金属形成单核或多核配合物已有较多报道 ,但以二硫代草酰胺 (H2 dto)作桥联基的双核铜配合物的合成报道仍较少[1 ] 。本文以 H2 dto作桥联基 ,乙二胺 (en)或二乙烯三胺 (dien)作端接配体 ,合成了两个新的双核配合物 [Cu2 (en) 2 (dto) ](Cl O4) 2 .3H2 O(1)和 [Cu2 (dien) 2 (dto) ](Cl O4) 2 .2 H2 O(2 ) ,另外用二环己酮草酰二腙 (BCO)作桥联基 ,以 2 ,2′-联吡啶作端接配体 ,合成了一个新型草酰胺类双核铜配合物 [Cu2 (bipy) 2 (BCO) (Cl O4) 2 ](Cl O4) 2 (3) ,研… 相似文献
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N,N'-二取代一硫代草酰胺的合成及其与二元胺反应的研究陆忠娥,邹建平,袁于人,陈克潜(苏州大学化学系,苏州,215006)关键词N,N'-二取代一硫代草酰胺,咪唑啉,四氢嘧啶N,N'-二硫代草酰胺可与多种金属络合,而N,N'-二取代一硫代草酰胺的合... 相似文献
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通过4-(4-吡啶基甲基硫代)苯甲酸与三苯基氧化锡以及三环己基氢氧化锡反应,合成了三苯基锡4-(4-吡啶基甲基硫代)苯甲酸酯(1)及三环己基锡4-(4-吡啶基甲基硫代)苯甲酸酯(2)。它们的结构通过红外,核磁以及X-射线单晶衍射分析得到确证。化合物1表现为一维链状结构,而化合物2通过分子间的O-H…O和O-H…N氢键形成二维网状结构。生物活性测试表明,这2个化合物具有较高的抗肿瘤活性。 相似文献
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利用2-碘酰基苯甲酸(IBX)的氧化作用,在四丁基溴化铵(TBAB)作为添加剂的条件下,硫酚、硫醇类化合物在室温快速反应生成相应的硫代磺酸酯类化合物,共获得了11个硫代磺酸酯,产率为54%~83%;而该氧化体系在加入浓盐酸(w=36%)或浓氢溴酸(w=46%)的条件下,硫酚或硫醇均顺利被氧化卤代成相应的磺酰氯或磺酰溴,分别获得了11个磺酰氯和11个磺酰溴产物,产率为62%~84%.这两种体系都简单、高效,使用了绿色氧化剂和溶剂、具有处理简单、条件温和等优点,所有合成产物均经1H NMR、13C NMR结构确证. 相似文献
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1-Benzoyl-3-benzylguanidine and 1-benzoyl-3-benzyl-O-ethylisourea were synthesized in good yields (68 and 76%, respectively) from 1-benzoyl-3-benzylthiourea and benzoyl-ethylthiocarbamate in dry media conditions using KF-Al2O3 under microwave irradiation. Strong nucleophilic amines promoted the sulfur elimination by attack on the thiocarbonyl group in both thiourea and thiocarbamates to afford guanidines and isourea, respectively. Transesterification products were obtained from p-TsOH catalyzed reaction of thiocarbamate with alcohols under MW-solvent-free conditions. Very important non-purely thermal MW specific effects were evidenced and attributed to stabilization by coulombic interactions between materials and waves. 相似文献
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F. J. Caires L. S. Lima C. T. Carvalho A. B. Siqueira Oswaldo Treu-Filho M. Ionashiro 《Journal of Thermal Analysis and Calorimetry》2012,107(1):335-344
Synthesis, characterization, and thermal behavior of transition metal oxamates, M(NH2C2O3)2·nH2O (M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II)), as well as the thermal behavior of oxamic acid and its sodium salt
(NaNH2C2O3) were investigated employing simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), experimental and
theoretical infrared spectroscopy, TG-DSC coupled to FTIR, elemental analysis and complexometry. The results led to information
about the composition, dehydration, thermal stability, thermal decomposition, as well as of the gaseous products evolved during
the thermal decomposition of these compounds in dynamic air and N2 atmospheres. 相似文献
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This study was designed to evaluate the isolated flavonoids (chrysin 1, and umbelliferone 2) from Potentilla evestita for cytotoxic, antitumour-promoting and inhibition of protein denaturation activities. The results showed marked cytotoxic effect of compounds 1 and 2 in brine shrimp cytotoxic assay at various concentrations with LD50 of 34.5 and 31.8 mg/mL, respectively. In Epstein–Barr-virus early antigen activation assay, both compounds 1 and 2 illustrated significant antitumour-promoting effect with IC50 values of 462 and 308 mol ratio/32 pmol TPA, respectively. The cytotoxic and antitumour-promoting effects of compounds were strongly supported by inhibition of protein denaturation activity with IC50 of 119 and 112 μg/mL, respectively. In conclusion, both compounds possess strong cytotoxic, antitumour-promoting and inhibition of protein denaturation activities. 相似文献
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The possibility of indirect and direct electrosyntheses of thiocarbamates is studied. The indirect synthesis is based on producing
monochloramines by the chlorination of an aqueous solution containing an amine and sodium chloride on a dimensionally stable
anode (DSA) in diaphragm electrolysis and a subsequent interaction of monochloramines with potassium xanthate. Optimum synthesis
conditions are found ensuring a current efficiency for thiocarbamates of 43-60%. These are:c
amine
= 0.17-2 M, cNaC1 = 4 M,ja = 20-30 A dm-2, electrolysis temperature 10‡C, the chloramine : potassium xanthate : amine molar ratio of 1 : 1.1 : 2, and the temperature
of the reaction between chloramine and potassium xanthate of 8‡C. The direct synthesis of thiocarbamates is realized in diaphragm
electrolysis when oxidizing an aqueous solution containing an amine, potassium xanthate, and sodium chloride on DSA. With
the electrosynthesis of ethyl ester of methylthiocarbamic acid as an example, conditions are found that allow one to obtain
a target product with a current efficiency of about 44%. However, the direct synthesis is accompanied by the destruction of
the anode material. 相似文献
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Unsymmetrical ureas and S‐thiocarbamates were prepared in good to excellent yields by direct condensation of phenylurea with amines and thiols in 1‐butyl‐3‐methylimidazolium tetrafluoroborate ([BMIM]BF4) without the addition of any additives. The [BMIM]BF4 ionic liquid is a mild medium and can be recycled and reused several times. 相似文献
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Photoreduction of carbamates, thiocarbamates and carbonate occurs in a mixture of HMPTH2O. A better yield of alkane is observed for thiocarbamates. Formates and photoFries products are also isolated from the reaction mixture. Radical intermediates can be trapped by cyclohexene even in HMPA. 相似文献
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Nine 5-aryl-2-methyloxazole derivatives were synthesized via gold-catalyzed alkyne oxidation. All of the compounds have been screened for their antiproliferative activities against MCF-7 cell (human breast carcinoma), A549 cell (human lung carcinoma) and Hela cell (human cervical carcinoma) lines in vitro. The results revealed that compounds 1b, 1c and 1d exhibited strong inhibitory activities against the MCF-7 cell lines (with ICso values of 4.6, 9.7 and 2.2 μmol/L, respectively). 相似文献
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Taking natural product phenazine-1-carboxamide (PCN) as a lead compound, a series of novel phenazine-1-carboxylic acid diamide derivatives were designed and synthesised. Their structures were confirmed by 1H-NMR and HRMS. The bioassays showed that some of the target compounds exhibited promising in vitro fungicidal activities, and exhibited excellent and selective herbicidal activities. Particularly, compounds c, h, o and s displayed root length inhibition activities against barnyard grass with the rate of more than 80%. Compound c exhibited the best activity among all the target compounds against barnyard grass stalk length with the IC50 value of 0.158 mmol/L, and compound o exhibited the best and wide spectrum inhibition against barnyard grass root length and rape in both root length and stalk length herbicidal activities with its IC50 values of 0.067, 0.048 and 0.059 mmol/L respectively. The analysis of preliminary Structure-Activity Relationships provides the theoretical basis for further design of phenazine-1-carboxylic acid. 相似文献
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Chiral α-aminophosphonates were synthesized using (R) or (S)-1-phenylethylamine in the presence of BF3·Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by ^1H NMR, ^19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α-aminophosphonates containing fluorine moiety. 相似文献
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1,2-cis-Fused bicyclic sugar thiocarbamates of gluco and manno configurations have been prepared by treatment of the corresponding O-unprotected amino sugars and glycopyranosyl amines with thiophosgene. The reactivity of these compounds towards amines has been studied in order to determine whether these compounds could act as latent isothiocyanates; it is shown that 1,2-cis-fused bicyclic sugar thiocarbamates are more stable than their trans analogues, and are not transformed into thioureas upon treatment with amines. An unprecedented isomerization of a peracetylated glucopyranoso[2,1-d]oxazolidine-2-thione into a glucopyranoso[2,1-d]thiazolidin-2-one in DMF is also reported. The structure of this thiazolidin-2-one was confirmed by X-ray crystallography. 相似文献