共查询到20条相似文献,搜索用时 105 毫秒
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1-取代苯基-1,4-二氢-6-甲基-4-哒嗪酮-3-酰氨基硫脲的合成及其抗烟草花叶病毒活性 总被引:8,自引:0,他引:8
用1-芳基-1,4-二氢-6-甲基-4-氧哒嗪-3-酰肼与取代苯基异硫氰酸酯反应合成了系列新型取代-1,4-二氢-6-甲基-4-哒嗪酮-3-酰氨基硫脲化合物,其结构经IR,1H NMR及元素分析确认,生物活性测定表明,该类化合物对烟草花叶病毒具有很高的抑制活性。 相似文献
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先合成1,2,4-三嗪环,然后并接吡唑环,对标题化合物进行了合成研究。对1,2,4-三嗪环上的硫化反应进行了改进,解决了3个反应活性相近部位的选择性肼解问题;并发现了肼基与乙酸乙酯于室温下反应生成1,3,4- 二唑环的新反应。 相似文献
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二唑衍生物具有抗菌、消炎和调节植物生长等活性[1~5].二唑硫醚衍生物也具有一定抗菌活性[6].为筛选具有生物活性的新化合物和研究亲核取代反应的规律,我们设计和合成了新的2-酰肼基-5-(2,4-二氯苯基)-1,3,4-二唑2,研究了2在K2C... 相似文献
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6-硝基苯并咪唑杂环衍生物的合成 总被引:1,自引:0,他引:1
以6-硝基苯并咪唑-1-乙酰肼和5-(6-硝基苯并咪唑-1-亚甲基)-3-巯基-4-氨基-1,2,4-三唑为原料,在不同条件下合成了一系列新的均三唑〔3,4-b〕-1,3,4-噻二唑,1,2,4-三唑和1,3,4-恶二唑衍生物。化合物的结构均经元素分析、^1H NMR、IR和MS确证,并对其波谱性质进行了讨论。 相似文献
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微波作用下2,5-二取代-1,3,4-噁二唑的合成 总被引:2,自引:0,他引:2
2 ,5 二取代 1 ,3 ,4 二唑可用作药品 ,光敏物质 ,闪烁体 ,激光材料 ,高分子液晶单体等[1- 5] 。一种是以芳香酸与水合肼作为原料用多聚磷酸作为脱水环合剂来合成此类化合物[6 ] ,另一种是由芳香酸转变为芳香酰氯或酯 ,再与水合肼反应得到单酰肼或二酰肼 ,最后用三氯氧磷[7] ,五氧化二磷和五氯化磷[8] ,一氯三甲硅[9] 脱水环合 ;此外 ,用水合肼和尿素合成得到的氨基脲代替水合肼 ,与芳香酸缩合合成二唑[10 ] ,这些方法共同的缺陷是 :环合时间较长 ,少者 4~ 5h ,多则 8h。近年来 ,微波技术在有机合成及其杂环化合物的合成中得到了广… 相似文献
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3-(3'-乙酰基-5'-芳基-1',3',4'-二氢噁二唑-2'-)色酮的微波促进合成 总被引:2,自引:0,他引:2
将微波应用于促进有机合成是近年来兴起的新技术,已受到极大注意,我们采用简单的微波反应装置,成功地合成了3-杂环基取代的色酮,杂环基取代的色酮因其显著的生理活性,而成为近年来的研究特点,以3-甲酰基色酮为原料,与芳酰肼反应得到相应的芳酰腙,再用乙酸酐关环,合成了一系列3位为1,3,4-二氢恶二唑基取代的色酮(3),为在合适的母体上引入杂环提供了一系新思路,合成路线如下。 相似文献
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Bioassay-directed fractionation of the ethyl acetate extracts of the stem bark of Aegle marmelos Correa (Rutaceae) afforded a new compound, named skimmiarepin C, along with skimmiarepin A. The latter is a known compound but isolation from A. marmelos is new. The new compound is a senecioate ester analogue of the latter. Full identification of the new compound was achieved using spectroscopic methods on the separated mono-acetate derivatives. Skimmiarepins A and C exhibit moderate insecticidal activity against Phaedon cochleariae and Musca domestica in comparison with natural pyrethrum extract. The two epimeric acetates of skimmiarepin C are both less active. 相似文献
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The main cytotoxic compound from the liverwort Lepidolaena taylorii is the known ent-8,9-seco-7-hydroxy-kaura-8(14),16-dien-9,15-dione1. The relative stereochemistry of a new cytotoxic compound, 16,17-dihydro derivative 2, was supported by molecular modelling. Another new cytotoxic compound was identified as 8,14-epoxide 3 by preparation from 1. These compounds showed differential cytotoxic activity against human tumor cell lines. 相似文献
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Sakamoto M Moriyasu T Minowa K Kishimoto K Kadoi H Hamano T Fukaya H 《Journal of AOAC International》2012,95(4):1048-1052
A sildenafil-related compound was detected in a dietary supplement marketed as an aphrodisiac. The compound was detected during analysis of the dietary supplement using LC-UV and LC/electrospray ionization-MS. The structure of the compound was established using high resolution MS, NMR spectrometry, and X-ray crystal structure analysis. The compound was identified as 5-(5-((3,5-dimethylpiperazin-1-yl)sulfonyl)-2-ethoxyphenyl)-l-methyl-7-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-3-propyl-1H-pyrazolo[4,3-d] pyrimidine. Based on this structure, the compound was named nitroprodenafil. The dietary supplement was found to contain 90 mg nitroprodenafil/capsule. This article describes the structural characterization of a new sildenafil-related compound. The compound was detected during analysis of a dietary supplement using LC-UV and LC/electrospray ionization (ESI)-MS. The structure was established using high resolution MS (HRMS), NMR spectrometry, and X-ray crystal structure analysis. The structures of methisosildenafil, thiomethisosildenafil, and this new analog, named nitroprodenafil (21), are shown in Figure 1. In the Demizu et al. report, the compound is named mutaprodenafil instead ofnitroprodenafil. Considering the naming right, the authors of this paper think the use of mutaprodenafil is appropriate as the compound name, although nitroprodenafil is used. 相似文献
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(33):10013-10017
Herbicide resistance is driving a need to develop new herbicides. The evolutionary relationship between apicomplexan parasites, such as those causing malaria, and plants is close enough that many antimalarial drugs are herbicidal and so represent novel scaffolds for herbicide development. Using a compound library from the Medicines for Malaria Venture, the model plant Arabidopsis thaliana, and a physicochemical database of known herbicides, a compound was discovered that showed post‐emergence herbicidal activity equal to commercial herbicides. Using structure–activity analysis, important points for its potency were found. The compound was also tested and found to be active against common crop weeds. Physiological profiling suggested the compound was a photosystem II inhibitor, representing a new scaffold for herbicide development. Overall this approach demonstrates the viability of using antimalarial compounds as lead compounds for the development of much needed new herbicides. 相似文献
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GuangFeiLIU LangLIU DianZengJIA KaiBeiYU 《中国化学快报》2003,14(12):1230-1232
A new photochromic compound containing pyrazolone-ring was synthesized, and its crystal structure was determined on X-ray singlecrystal diffraction, which belongs to monoclinic crystal system, space group P21/c. The UV spectrum of the compound is studied. 相似文献
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Casey Chun Zhou Eric J. Stoner Kent D. Stewart L. Steven Hollis Edmund D. Matayoshi Gregory M. Brill 《Tetrahedron》2004,60(47):10611-10618
Oritavancin is a semi-synthetic glycopeptide antibiotic which is structurally related to vancomycin. When oritavancin bisphosphate is dried in vacuo with heat, a new compound forms. This new compound is stable only in the solid state and reverts to oritavancin in solution. Highly enriched samples of this compound were obtained by preparative HPLC and the structure of this compound was elucidated by using one and two-dimensional (1H and 13C) NMR spectroscopy in conjunction with computer-assisted molecular modeling. It has been determined that oritavancin adopts a conformation similar to that of vancomycin in solution, while the new compound is the unnatural R-AB-biaryl atropisomer of oritavancin. This is the first observation and isolation of an AB-biaryl atropisomer in an intact member of the vancomycin family of glycopeptide antibiotics. 相似文献
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C S Yang M Hashimoto N Baba M Takahashi H Kaneto N Kawano I Kouno 《Chemical & pharmaceutical bulletin》1990,38(1):291-292
A new toxic neoanisatin-derivative (1) was isolated from the pericarps of Illicium majus. The structure of this compound was elucidated by spectroscopic data, including the 2D COSY NMR technique. The toxicity of compound 1 is also described. 相似文献
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设计并合成了一种基于喹诺酮衍生物的双极绿色磷光主体材料1-甲基-3-[4-(9-咔唑基)苯基]-4-苯基喹啉-2(1 H)-酮.计算发现,化合物的HOMO轨道的电子云位于咔唑基团,LUMO轨道的电子云位于喹诺酮基团,是一种良好的双极材料.化合物的磷光发射峰为515 nm(2.41 eV),符合绿色磷光主体材料的基本要求(>2.4 eV).热失重和差热分析结果表明,该化合物具有较高的热稳定性,分解温度和玻璃化转变温度分别为312℃和105℃.研究结果表明:该新型化合物是一种潜在的具有双极特性的绿色磷光主体材料. 相似文献