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1.
Addition of trichloronitrosomethane to 1,3-cycloalkadienes gives [2+4] cpclo-adducts. However, reactions with acyclic 1,3-butadienes afford unstable cycloadducts which hydrolyze in water-ether solution to produce N-chloroformyl-3,6-dihydro-l, 2-oxazines. The later compounds are reduced to N-methyl or converted to N-methoxylcarbonyl derivatives in high yields. 相似文献
2.
Summary 3,6-Dichloro- and 3,6-dibromo-8-quinolinols were prepared by direct halogenation of 8-nitroquinoline by N-halosuccinimide in acetic acid or by halogenation of the corresponding 6-halo-8-nitroquinoline prepared via aSkraup reaction. The nitro group was reduced to amino and the amine was hydrolyzed to the phenol in 70% sulfuric acid at 220°C. The fungitoxicity of 3,6-dichloro- and 3,6-dibromo-8-quinolinols, as well as intermediates in their preparation, againstAspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, andMucor cirinelloides was determined. 3,6-dichloro-8-quinolinol is the most fungitoxic analogue of this class of compounds observed to date.
Herstellung und Fungitoxizität von 3,6-Dichlor- und 3,6-Dibrom-8-chinolinen
Zusammenfassung 3,6-Dichlor- und 3,6-Dibrom-8-chinoline wurden durch direkte Halogenierung von 8-Nitrochinolin mit N-Halogensuccinimid in Essigsäure oder durch Halogenierung der entsprechenden nachSkraup synthetisierten 6-Halogen-8-nitrochinoline hergestellt. Die Nitrogruppe wurde zum Amin reduziert und die Aminofunktion in 70% iger Schwefelsäure bei 220°C zum Phenol hydrolysiert. Die Fungitoxizität der 3,6-Dichlor- und 3,6-Dibrom-8-chinoline und jene der bei ihrer Herstellung auftretenden Zwischenstufen gegenAspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride undMucor cirinelloides wurde bestimmt. 3,6-Dichlor-8-chinolin ist der derzeit stärkste bekannte fungitoxische Vertreter dieser Substanzklasse.相似文献
3.
Abdullah M.A. ShumailaVedavati G. Puranik Radhika S. Kusurkar 《Tetrahedron letters》2011,52(21):2661-2663
Pictet-Spengler condensation of 2,5-bis(2-phenyl-1-aminoethyl)pyrrole using glacial acetic acid afforded only one diastereomer of unreported tetrasubstituted-octahydro-3,6-diazacarbazoles. These were readily dehydrogenated to tetrasubstituted-3,6-diazacarbazoles. The stereoselectivity in the Pictet-Spengler reaction has been demonstrated using single crystal X-ray analysis. 相似文献
4.
Yu Chuan Li Si Ping Pang Yong Zhong Yu 《中国化学快报》2007,18(5):516-518
The cyclization reaction of D-aspartic acid was studied, the carboxyl groups of D-aspartic acid were protected by benzyl alcohol to give compound D-dibenzyl aspartate. Then (4R)-benzyl azetidine-2-one-4-carboxylate and meso-3,6-disubstituted piperazine- 2,5-diones were synthesized via intramolecular cyclization and intermolecular cyclization of D-dibenzyl aspartate, respectively, and their structures were confirmed by 1H NMR and MS. Both cyclization reaction conditions were also investigated in detail. 相似文献
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6.
Koichi Sakamaki Joji Ohshita Atsutaka Kunai Hidenobu Nakao Akira Adachi Koichi Okita 《应用有机金属化学》2001,15(7):604-612
We have synthesized novel σ–π conjugated polymers with an alternating organosilanylene and π‐electron system, intending to utilize them for hole‐transporting materials of electroluminescent (EL) devices. 3,6‐Di(lithioethynyl)carbazoles were co‐polymerized with organodichlorosilanes to give the corresponding polymers with molecular weights of MW = 2000–5000. Another type of polymer with a thienylene unit was also synthesized by the nickel‐catalyzed reaction of the di‐Grignard reagent of 1,2‐bis[2‐(5‐bromothienyl)]tetraethyldisilane with 3,6‐dibromocarbazole, the molecular weight being Mn = 3100. The EL devices with a double‐layer system composed of tris(8‐quinolinolato)aluminum(III) and the present polymers as the emitting‐electron‐transporting and hole‐transporting layers, respectively, emit green EL with a maximum intensity of the order of 103 cd m?2. Of these, the device with the thienylene–carbazole polymers exhibited the highest luminance of 1480 cd m?2. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
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Shi Yong Fan Chun Lai Mi Jun Yang Song Li Zhi Bing Zheng 《中国化学快报》2007,18(4):400-402
The synthesis of a series of 3,6-dichloropyridazine derivatives was described.In vitro experiment,all compounds exhibited ananti-rhinovirus activity,and one of the compounds 6g showed the comparable activity as our lead compound pirodavir. 相似文献
9.
Montmorillonite-and cellulose-adsorbed 3,6-diaminoacridine are prepared. The adsorption isotherm studies show that while 3,6-diaminoacridine
molecules are adsorbed in the interlayer spaces of the montmorillonite clay, the dye molecules are adsorbed on the surface
of cellulose. Quenching studies reveal that the Al3+ ions of the aluminosilicate layers of the clay also quench the excited state emission of the adsorbed 3,6-diaminoacridine. 相似文献
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A novel series of 3,6-disubstituted coumarin derivatives were synthesized by the reaction of ethyl-2-(3-acetyl-2-oxo-2H-chromen-6-yl)-4-methylthiazole-5-carboxylate with thiosemicarbazide and various phenacyl bromides / 3-(2-bromoacetyl)-2H-chromen-2-ones / 2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one in ethanol having catalytic amount of acetic acid under reflux conditions with good yields. All the synthesized compounds were fully characterized by spectral studies and evaluated for their in vitro antibacterial activity against Pseudomonas aeruginosa, Bacillus subtilis (Gram positive), Escherichia coli, and Azatobacter (Gram negative) bacterial strains. Activity results revealed that the compound 6h against Escherichia coli and compound 6i against Pseudomonas aeruginosa and Escherichia coli have shown maximum zones of inhibition. Remaining compounds showed moderate to good activity against all the tested bacterial strains compared with the standard drug cefotaxime. 相似文献
12.
《Journal of Coordination Chemistry》2012,65(11):917-922
The structure of hydrazinium magnesium(II) pyridazine-3,6-dicarboxylate comprises two univalent hydrogen hydrazine cations, a divalent di(aqua-O)bis(pyridazine-3,6-dicarboxylato-N,O) magnesium(II) anion and two solvate water molecules in the triclinic unit cell. The magnesium(II) ion is located on the center of symmetry. The coordination around the magnesium(II) ion is slightly distorted octahedral. The ligand molecules are coplanar. Their N,O bonding moieties coordinated to the metal ion form the equatorial plane of the distorted octahedron (Mg–O 2.062?Å, Mg–N 2.176?Å) with two water ligands in the trans axial sites (Mg–O 2.047?Å). 相似文献
13.
Kurochkina G. I. Soboleva N. O. Grachev M. K. Vasyanina L. K. Nifant"ev E. E. 《Russian Chemical Bulletin》2003,52(4):1009-1012
Efficient procedures were developed for the synthesis of monophosphorylated derivatives of 1,4:3,6-dianhydro-D-mannitol. The latter are of interest as compounds bearing different phosphorus-containing fragments on a three-dimensional matrix having an inner chiral cavity. 相似文献
14.
Cecile Baudin Christophe Pean Bruno Pellizzari Andree Gadelle Florence Fauvelle Jean-Claude Debouzy Jean-Pierre Dalbiez Bruno Perly 《Journal of inclusion phenomena and macrocyclic chemistry》2000,38(1-4):287-296
We report on the synthesis,characterization and ionic complexation properties ofhexakis (2-O-acetyl-3,6-anhydro)cyclomaltohexaose and hexakis (2-O-methyl-3,6-anhydro) cyclomaltohexaose usingthin-layer chromatography and Nuclear MagneticResonance spectroscopy. The selectivity towardscations depends on chemical modification of thehydroxyl groups and a very high specificity can beobtained in the case of lead for methylatedderivatives. 相似文献
15.
Dongju Zhang Hui Sun Fang Wang Chengbu Liu 《International journal of quantum chemistry》2007,107(7):1585-1589
The NO migration from N‐methyl‐N‐nitrosobenzene‐sulfonamide to 3,6‐dibromocarbazole was proposed in a recent literature to follow a stepwise reaction path. However, the present density functional theory calculations at the MP2/6–31G(d,p)//B3LYP/6–31G(d,p) level show that this reaction exclusively proceeds via a concerted mechanism involving a four‐membered ring transition state. The calculated barrier is in good agreement with the experimental finding. © 2007 Wiley Periodicals, Inc. Int J Quantum Chem, 2007 相似文献
16.
A novel and efficient strategy is described for the asymmetric synthesis of the first 3,6-anhydrosugar to be isolated from natural sources, furanodictine A. The synthetic process is based on requisite stereodefined manipulation of the functionalized amino alcohol obtained through nucleophilic addition of vinyl Grignard reagent to the aminal incorporating the d-arabinofuranose-derived skeleton in a complete stereoselective manner. 相似文献
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M. Komal Reddy T. Ravinder Reddy K. Raghava Raju 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):313-318
This article describes the reaction of 3,6-diphenyl-thieno[3,2-b]furan-2,5-dione 1 with different amino acids 2a–j in glacial acetic acid which afforded the 2-(2-(3-hydroxy-5-oxo-4-phenylthiophen-2(5H)-ylidene)-2-phenylacetamido)propanoic acid analogues 3a–j and also describes the reaction of 3,6-diphenyl-thieno[3,2-b]thiophene-2,5-dione 4 with different amino acids 5a–e in acidic medium to give 2-(2-(3-mercapto-5-oxo-4-phenylthiophen-2(5H)-ylidene)-2-phenylacetamido)propanoic acid analogues 6a–e. All the compounds have been screened for their anti-inflammatory activity against the carrageenan induced rat paw edema in albino rats. In the primary screening, some of the compounds exhibited appreciable activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
19.
Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine (1) with benzyl, aryl, and alkyl organozinc compounds led to selective mono-substitution of one of the chlorine atoms. The subsequent cross-coupling of the resulting monochlorides with RZnCl afforded unsymmetrical 3,6-carbon-disubstituted pyridazines. 相似文献
20.
E. V. Kudrik M. A. Zharnikova E. A. Deryabkina G. P. Shaposhnikov 《Russian Chemical Bulletin》1998,47(6):1220-1222
The reactions of 3- and 4-nitrophthalimides with hydroxylamine in aqueous alcohol media were studied. A mixture of 3-amino-4-nitro-
and 4-amino-5-nitrophthalimides is formed in the case of 4-nitrosubstituted derivative, whereas 3,6-dihydroxyphthalimide is
unexpectedly found to be the main product of the reaction of 4-nitrosubstituted derivative. A possible mechanism of the transformation
was suggested.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1250–1252, June, 1998. 相似文献