水杨醛缩对氨基水杨酸席夫碱及稀土配合物的合成、表征与抑菌活性

以水杨醛和对氨基水杨酸反应制得水杨醛缩对氨基水杨酸席夫碱,并以此席夫碱为配体与水合醋酸稀土盐反应,合成了新的稀土配合物.通过元素分析、摩尔电导、IR、1H-NMR等测试技术对其结构进行了表征:配体与稀土离子按照2∶1进行配位,中心金属离子的配位数为6,组成为[C_(28)H_(20)N_2O_8RE]·2H_2O,其中RE=(La,Ce,Pr,Gd,Dy,Er).抑菌实验初步表明,合成的席夫碱及其配合物对实验选用的细菌有不同程度的抑制活性,而且稀土配合物的抑菌活性更突出.     

3,5—二溴水杨醛Schiff碱的铜（Ⅱ）配合物研究

３，５－二溴水杨醛Ｓｃｈｉｆ碱的铜（Ⅱ）配合物研究赵全芹柳翠英王德凤于爱华（山东医科大学药学系济南２５００１２）关键词３，５－二溴水杨醛Ｓｃｈｉｆ碱配合物抑菌活性中图分类号Ｏ６１４．１２１Ｓｃｈｉｆ碱衍生物与过渡金属离子所形成的配合物具有抗癌、抗病毒...     

一种新的不对称Schiff碱与稀土配合物合成机理及波谱

采用一种新途径 ,利用反应物前体 2 ,6 二氨基己酸 (赖氨酸 )两端具有不对称结构的—NH2 基 ,成功地合成了一端与水杨醛 ,另一端与邻香草醛缩合形成的新型不对称双Schiff碱 .为与通常不对称Schiff碱区别起见 ,称之为“异双Schiff碱” .提出了这类Schiff碱及配合物的合成方法 ,并以此分别合成了包括钇的 1 2种稀土不对称Schiff碱新配合物 .对它们作了元素分析、摩尔电导、红外光谱 ,特别是1H与13 CNMR等表征 ,并研究和讨论了这类不对称Schiff碱分步缩合反应及其形成机理与稀土离子配位方式 .为合成类似不对称Schiff碱与配合物提供了一种新方法 .     

新型吡唑Schiff碱及金属配合物的合成和抑菌活性

以3-氨基-4-氰基吡唑和芳醛为原料合成了10个新型吡唑Schiff碱及铜(II)、镍(II)、锌(II)、钴(II) 4个金属配合物. 用元素分析, IR, 1H NMR及单晶解析表征了Schiff碱及金属配合物的结构. 测定了Schiff碱及金属配合物对金黄色葡萄球菌、大肠杆菌、枯草杆菌和绿脓杆菌的抑菌活性. 生物活性研究表明, Schiff碱及金属配合物对金黄色葡萄球菌、大肠杆菌和绿脓杆菌都有较好的抑菌效果, 其中铜(II)和锌(II)配合物对金黄色葡萄球菌和大肠杆菌的抑菌活性最好.     

2-氨基噻唑缩取代水杨醛Zn(Ⅱ)配合物的合成、表征及抑菌活性

合成了４个２－氨基噻唑缩取代水杨醛Ｚｎ（Ⅱ）的配合物,通过元素分析,ＩＲ,１ＨＮＭＲ及ＵＶ－ｖｉｓ光谱进行了结构表征。抑菌实验结果表明,配合物的活性优于配体     

邻香兰素缩邻氨基苯甲酸与稀土硝酸盐配合物的合成与表征

邻香兰素缩邻氨基苯甲酸与稀土硝酸盐配合物的合成与表征范玉华毕彩丰赵淑英（山东建材学院应用化学系济南２５００２２）程桂英（山东省化工学院济南２５００００）关键词稀土硝酸盐希夫碱配合物中图分类号Ｏ６４１．４某些水杨醛类氨基酸的金属配合物具有显著的生物活性...     

糠醛甘氨酸Schiff碱及其稀土La(Ⅲ)配合物的合成与表征

糠醛甘氨酸Schiff碱稀土配合物具有生理活性。本文采用分步法制得Schill碱配合物：     

5—氯水杨醛缩硫脲Schiff碱与锰配合物的合成及其对超氧离子 …

目前人们普遍认为引起炎症、衰老、癌症、肿瘤的原因之一是生物体内存在过量的超氧阴离子自由基(O-2)[1～2].文献表明Schiff碱类及其过渡金属配合物对O-2具有一定的抑制率[2],特别是含O、N、S的Schiff碱类配合物具有很高的抗癌活性 [3～4],锰也有一定的生物活性.本文合成出了目前未见文献报道的5-氯水杨醛缩硫脲Schiff碱配体及其锰(Ⅱ)配合物,测定了其组成与结构,探讨了对O-2的抑制作用 ,结果表明该种配合物结构稳定,生物活性高,在医学及生物学上可能具有一定的应用前景.     

新型水杨醛衍生物基Schiff碱的合成及其抑菌活性

以(取代)水杨醛、间(对)羧基苯胺和氨基甲酰肼为原料,分别采用冰浴法合成了4-(二乙基氨基)水杨醛-3-羧基苯胺(3a),4-(二乙基氨基)水杨醛-4-羧基苯胺(3b)和水杨醛-3-羧基苯胺(3c);采用固相法合成了4-(二乙基氨基)水杨醛-氨基甲酰肼(3d);采用水浴回流法合成了3,5-二溴水杨醛-4-羧基苯胺(3e)和2-羟基-1-萘甲醛-4-羧基苯胺(3f),3a~3f均为新化合物,其结构经1H NMR,IR,ESI-MS和元素分析表征。研究了3a~3f对大肠杆菌、金黄色葡萄球菌及欧文氏草生杆菌的抑菌活性。结果表明:3a~3f对受试菌种均有一定的抑菌活性,其中3e的抑菌活性最好。     

稀土氨基酸水杨醛Schiff碱的合成及其生物活性

合成了水杨醛L-亮氨酸Schiff碱钇配合物{[Y2(Leu-Sal)3Cl4]Cl2.2H2O,Leu=L-亮氨酸,Sal=水杨醛},其结构经UV,IR,荧光光谱,元素分析,摩尔电导和差热-热重分析表征。生物活性实验表明,配合物对大肠杆菌、金黄色葡萄球菌和霉菌均有不同程度的抑菌作用。     

Organogermyl,Organostannyl, and Organoplumbyl Phosphines,Arsines, Stibines,and Bismuthines

The preparation, properties, and reactions of the compounds named in the title are described, with particular reference to the possible participation of (p→d)_π components in the bonding between the group IVB and the group VB elements.     

Pyrenes,Peropyrenes, and Teropyrenes: Synthesis,Structures, and Photophysical Properties

The design of a relatively simple and efficient method to extend the π‐conjugation of readily available aromatics in one‐dimension is of significant value. In this paper, pyrenes, peropyrenes, and teropyrenes were synthesized through a double or quadruple benzannulation reaction of alkynes promoted by Brønsted acid. This novel method does not involve cyclodehydrogenation (oxidative aryl–aryl coupling) to arrive at the newly incorporated large arene moieties. All of the target compounds were synthesized in moderate to good yields and were fully characterized with the structures unambiguously confirmed by X‐ray crystallography. As expected, photophysical characterization clearly shows increasing red‐shifts as a function of extended conjugation within the fused ring systems.     

Pyrenes,Peropyrenes, and Teropyrenes: Synthesis,Structures, and Photophysical Properties

The design of a relatively simple and efficient method to extend the π‐conjugation of readily available aromatics in one‐dimension is of significant value. In this paper, pyrenes, peropyrenes, and teropyrenes were synthesized through a double or quadruple benzannulation reaction of alkynes promoted by Brønsted acid. This novel method does not involve cyclodehydrogenation (oxidative aryl–aryl coupling) to arrive at the newly incorporated large arene moieties. All of the target compounds were synthesized in moderate to good yields and were fully characterized with the structures unambiguously confirmed by X‐ray crystallography. As expected, photophysical characterization clearly shows increasing red‐shifts as a function of extended conjugation within the fused ring systems.     

Structural, magnetic, and spectroscopic studies of YAgSn, TmAgSn, and LuAgSn

The rare earth-silver-stannides YAgSn, TmAgSn, and LuAgSn were synthesized from the elements by arc-melting and subsequent annealing. The three stannides were investigated by X-ray powder and single-crystal diffraction: NdPtSb type, P6₃mc, Z=2, a=468.3(1), pm, wR₂=0.0343, 353 F² values, 12 variables for YAgSn, and ZrNiAl type, P6¯2 m, a=726.4(2), , wR₂=0.0399, 659 F² values, 15 variables for TmAgSn, and a=723.8(2), , wR₂=0.0674, 364 F² values, 15 variables for LuAgSn. Besides conventional laboratory X-ray data with monochromatized Mo radiation, the structures were also refined on the basis of synchrotron data with , in order to clarify the silver-tin ordering more precisely. YAgSn has puckered, two-dimensional [AgSn] networks with Ag-Sn distances of 278 pm, while the [AgSn] networks of TmAgSn and LuAgSn are three-dimensional with Ag-Sn distances of 279 and 284 pm for LuAgSn. Susceptibility measurements indicate Pauli paramagnetism for YAgSn and LuAgSn. TmAgSn is a Curie-Weiss paramagnet with an experimental magnetic moment of 7.2 μ_B/Tm. No magnetic ordering is evident down to 2 K. The local environments of the tin sites in these compounds were characterized by ¹¹⁹Sn Mössbauer spectroscopy and solid-state NMR (in YAgSn and LuAgSn), confirming the tin site multiplicities proposed from the structure solutions and the absence of Sn/Ag site disordering. Mössbauer quadrupolar splittings were found in good agreement with calculated electric field gradients predicted quantum chemically by the WIEN2k code. Furthermore, an excellent correlation was found between experimental ¹¹⁹Sn nuclear magnetic shielding anisotropies (determined via MAS-NMR) and calculated electric field gradients. Electronic structure calculations predict metallic properties with strong Ag-Sn bonds and also significant Ag-Ag bonding in LuAgSn.     

Borinium, borenium, and boronium ions: synthesis, reactivity, and applications

Boron cations are elusive and highly electrophilic species that play a key role in the chemistry of boron. Despite early interest in the chemistry of boron cations, until recently they have largely remained chemical curiosities. However, hints at harnessing their potential as potent electrophiles have begun to appear and developments in weakly coordinating anion technology suggest that this is an area of research that is ripe for exploration. It has been nearly 20 years since the last major review on boron cations; herein we summarize the progress in the area since that time.     

Pi bonding and negative hyperconjugation in mono-, di-, and triaminoborane, -alane, -gallane, and -indane

A systematic quantum chemical investigation of mono-, di-, and triaminoborane, -alane, -gallane, and -indane is carried out to determine quantitatively the effects of pi bonding and negative hyperconjugation on structures, energetics, and rotational barriers in these systems. Pi bonding plays a significant role in the aminoborane compounds, but becomes rapidly less significant in the aminoalanes, -gallanes, and -indanes. For each main-group metal X investigated, X-N rotational barriers are found to be essentially equal depending only on the number of remaining in-plane amino groups. The contribution of negative hyperconjugation to reducing rotational barriers, as assessed from natural bond orbital (NBO) delocalization energies, is independent of the pyramidalization of the out-of-plane amino group, and is also dependent only on the number of rotated groups. Optimized tris[bis(trimethylsilyl)amino]-substituted structures of boron, aluminum, gallium, and indium are found to compare quite well with available experimental structural data, and exhibit X-N torsion angles that are independent of the central metal atom.     

铬,硒,镉,锰与心脑血管疾病

通过对５０例心脑血管疾病病人及５０例健康对照组血中微量元素铬、硒、镉、锰的检测分析证实，心脑血管疾病病人血清Ｃｒ、Ｓｅ含量下降，Ｃｄ含量未见明显升高，并进一步探讨了这些微量元素与心脑血管疾病的发生发展的关系及其临床意义。     

Rare-Earth-compound nanowires, nanotubes, and fullerene-like nanoparticles: synthesis, characterization, and properties

Various low-dimensional nanostructures, such as nanowires, nanotubes, nanosheets, and fullerene-like nanoparticles have been selectively synthesized from rare-earth compounds (hydroxides, fluorides) based on a facile hydrothermal method. The subsequent dehydration, sulfidation, and fluoridation processes lead to the formation of rare-earth oxide, oxysulfide, and oxyhalide nanostructures, which can be functionalized further by doping with other rare-earth ions or by coating with metal nanoparticles. Owing to the interesting combination of novel nanostructures and functional compounds, these nanostructures can be expected to bring new opportunities in the vast research areas of and application in biology, catalysts, and optoelectronic devices.     

Synthesis of yttrium,lanthanum, neodymium,praseodymium, and lutetium alkoxides and acetylacetonates

A convenient and practical method is proposed for the synthesis of lanthanide and yttrium alkoxides. The method involves dissolving the metals or their hydrides in a solution of dry HCl in the corresponding alcohol, with subsequent dehalogenation of the LnCl₃ solution by an equivalent amount of alkali metal (Na, Li), The rareearth alkoxides are easily converted into acetylacetonates Ln(acac)₃ by the action of acetylacetone.A. N. Nesmeyanov Institute of Elementoorganic Compounds, Russian Academy of Sciences, 117813 Moscow. Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 11, pp. 2490–2493, November, 1992.