共查询到20条相似文献,搜索用时 93 毫秒
1.
2.
meso-四(对-磺酸基苯基)卟啉对麦芽糖的分子识别高爽,王杏乔,于连香,曹锡章(吉林大学化学系,长春,130023)关键词卟啉,麦芽糖,分子识别分子识别在生物和生命活动中起着重要作用。近年来,以卟啉及其配合物为接受体对生物分子的人工分子识别研究日趋... 相似文献
3.
新型手性酪氨酸卟啉锌对咪唑类客体的分子识别研究 总被引:3,自引:0,他引:3
合成了两种新型手性锌卟啉Zn(o-BocTyr)TAPP和Zn(p-BocTyr)TAPP.通过元素分析、紫外可见光谱及核磁共振谱对其性质进行了表征.研究了这两种锌卟啉对咪唑类的分子识别行为,识别的缔合常数顺序均为K(2-MeIm)>K(Im)>K(N-MeIm)>K(2-Et-4-MeIm).同时,采用理论计算和圆二色谱研究了咪唑类小分子在与锌卟啉分子识别时进攻主体位置的变化,这对于研究卟啉分子识别起到一定的作用. 相似文献
4.
5.
双-锌卟啉对DABCO分子识别的立体构象及其热力学研究 总被引:2,自引:1,他引:1
合成了系列不同长度以柔性侧链相连的p/p型双-锌卟啉配合物,用1H NMR和UV-Vis研究了不同温度下该系列配合物与刚性双齿配体DABCO(1,4-二氮杂双环)的轴向配位反应,考察了侧链长度对双-锌卟啉与配体的分子识别能力影响。结果表明,主体分子双-锌卟啉可以对客体分子BABCO进行分子识别,合适长度的柔韧烷氧链可以调节主体分子的构象,使DABCO嵌入双卟啉两个卟啉环间空位中,形成锌卟啉-DABCO-锌卟啉三元夹心式配合物构象。探讨了配位反应中立体构象的变化过程,并测定了热力学参数。 相似文献
6.
7.
金属卟啉配合物作为主体分子对氨基酸酯及其衍生物的分子识别研究是当今卟啉仿生化学的重要课题[1-6]。这一领域的研究成果在生物传感器的研制,癌症的诊断和治疗,模拟含卟啉生物大分子的功能以及在生物大分子构象和类型的识别研究中具有潜在的应用价值[7]。氨基酸是弱的电子授体,将其连接在卟啉分子中可以改变卟啉配体的受授性质,同时氨基酸尾式卟啉更接近天然卟啉。另外,氨基酸是蛋白质的主要组成部分,在蛋白质的生物合成过程中,对氨基酸及其衍生物的识别是关键的一步。酰胺转移t-RNA合成酶对氨基酸表现出极为专一的立… 相似文献
8.
9.
10.
以5-(4-羟基苯基)-10,15,20-三苯基卟啉锌为印迹分子,4-乙烯基吡啶为功能单体,乙二醇二甲基丙烯酸酯为交联剂,合成了具有金属卟啉识别能力的分子印迹聚合物.紫外可见滴定光谱研究表明,功能单体与印迹分子在聚合前形成1:1的配合物.通过吸附试验、荧光光谱及斯卡查特分析法,考察了分子印迹聚合物对锌卟啉化合物的识别性能.结果表明,印迹聚合物对结构类似的卟啉化合物具有良好的识别能力,对印迹分子荧光性能的影响远大于其对应的非印迹聚合物.在浓度较低时,印迹聚合物对印迹分子的结合常数和最大结合量分别为:1.61×106L/mol和3.22×10-5mol/g. 相似文献
11.
In the 25 years since its Nobel Prize in chemistry, supramolecular chemistry based on molecular recognition has been paid much attention in scientific and technological fields. Nanotechnology and the related areas seek breakthrough methods of nanofabrication based on rational organization through assembly of constituent molecules. Advanced biochemistry, medical applications, and environmental and energy technologies also depend on the importance of specific interactions between molecules. In those current fields, molecular recognition is now being re-evaluated. In this review, we re-examine current trends in molecular recognition from the viewpoint of the surrounding media, that is (i) the solution phase for development of basic science and molecular design advances; (ii) at nano/materials interfaces for emerging technologies and applications. The first section of this review includes molecular recognition frontiers, receptor design based on combinatorial approaches, organic capsule receptors, metallo-capsule receptors, helical receptors, dendrimer receptors, and the future design of receptor architectures. The following section summarizes topics related to molecular recognition at interfaces including fundamentals of molecular recognition, sensing and detection, structure formation, molecular machines, molecular recognition involving polymers and related materials, and molecular recognition processes in nanostructured materials. 相似文献
12.
Xiaofan Ji Kelong Zhu Xuzhou Yan Yingjie Ma Jinying Li Bingjie Hu Yihua Yu Feihe Huang 《Macromolecular rapid communications》2012,33(14):1197-1202
All the previously reported supramolecular polymers based on crown ether‐based molecular recognition have been prepared in anhydrous organic solvents. This is mainly due to the weakness of crown ether‐based molecular recognition in the presence of water. Here we report a linear supramolecular polymer constructed from a heteroditopic monomer in an aqueous medium driven by crown ether‐based molecular recognition through the introduction of electrostatic attraction. In addition, the reversible transition between the linear supramolecular polymer and oligomers is achieved by adding acid and base. This study realizes the breakthrough of the solvent for supramolecular polymerization driven by crown ether‐based molecular recognition from anhydrous organic solvents to aqueous media. It is helpful for achieving supramolecular polymerization driven by crown ether‐based molecular recognition in a completely aqueous medium. 相似文献
13.
Ojida A Inoue MA Mito-Oka Y Hamachi I 《Journal of the American Chemical Society》2003,125(34):10184-10185
In the research field of molecular recognition, selective recognition and sensing of phosphorylated protein surfaces is strongly desirable both for elucidation of protein-protein recognition at the molecular level and for regulation of signal transduction through protein surfaces. Here we describe a new strategy for molecular recognition of a multi-phosphorylated peptide using intrapeptide cross-linking on the basis of coordination chemistry. The present artificial receptor can selectively bind to doubly phosphorylated peptide through multiple-point interactions and fluorescently sense the binding event with an association constant of more than 106 M-1 in neutral aqueous solution. 相似文献
14.
15.
Jean-Marie Lehn 《Angewandte Chemie (International ed. in English)》1990,29(11):1304-1319
The selective binding of a substrate by a molecular receptor to form a supramolecular species involves molecular recognition which rests on the molecular information stored in the interacting species. The functions of supermolecules cover recognition, as well as catalysis and transport. In combination with polymolecular organization, they open ways towards molecular and supramolecular devices for information processing and signal generation. The development of such devices requires the design of molecular components performing a given function (e.g., photoactive, electroactive, ionoactive, thermoactive, or chemoactive) and suitable for assembly into an organized array. Light-conversion devices and charge-separation centers have been realized with photoactive cryptates formed by receptors containing photosensitive groups. Eleclroactive and ionoactive devices are required for carrying information via electronic and ionic signals. Redox-active polyolefinic chains, like the “caroviologens”, represent molecular wires for electron transfer through membranes. Push-pull polyolefins possess marked nonlinear optical properties. Tubular mesophases, formed by organized stacking of suitable macro-cyclic components, as well as “chundle”-type structures, based on bundles of chains grafted onto a macrocyclic support, represent approaches to ion channels. Lipophilic macrocyclic units form Langmuir-Blodgett films that may display molecular recognition at the air-water interface. Supramolecular chemistry has relied on more or less preorganized molecular receptors for effecting molecular recognition, catalysis, and transport processes. A step beyond preorganization consists in the design of systems undergoing self-organization, that is, systems capable of spontaneously generating a well-defined supramolecular architecture by self-assembling from their components under a given set of conditions. Several approaches to self-assembling systems have been pursued: the formation of helical metal complexes, the double-stranded helicates, which result from the spontaneous organization of two linear polybipyridine ligands into a double helix by binding of specific metal ions; the generation of mesophases and liquid crystalline polymers of supramolecular nature from complementary components, amounting to macroscopic expression of molecular recognition; the molecular-recognition-directed formation of ordered solid-state structures. Endowing photo-, electro-, and ionoactive components with recognition elements opens perspectives towards the design of programmed molecular and supramolecular systems capable of self-assembly into organized and functional supramolecular devices. Such systems may be able to perform highly selective operations of recognition, reaction, transfer, and structure generation for signal and information processing at the molecular and supramolecular levels. 相似文献
16.
Jean-Marie Lehn 《Angewandte Chemie (International ed. in English)》1988,27(1):89-112
Supramolecular chemistry is the chemistry of the intermolecular bond, covering the structures and functions of the entities formed by association of two or more chemical species. Molecular recognition in the supermolecules formed by receptor-substrate binding rests on the principles of molecular complementarity, as found in spherical and tetrahedral recognition, linear recognition by coreceptors, metalloreceptors, amphiphilic receptors, and anion coordination. Supramolecular catalysis by receptors bearing reactive groups effects bond cleavage reactions as well as synthetic bond formation via cocatalysis. Lipophilic receptor molecules act as selective carriers for various substrates and make it possible to set up coupled transport processes linked to electron and proton gradients or to light. Whereas endoreceptors bind substrates in molecular cavities by convergent interactions, exoreceptors rely on interactions between the surfaces of the receptor and the substrate; thus new types of receptors, such as the metallonucleates, may be designed. In combination with polymolecular assemblies, receptors, carriers, and catalysts may lead to molecular and supramolecular devices, defined as structurally organized and functionally integrated chemical systems built on supramolecular architectures. Their recognition, transfer, and transformation features are analyzed specifically from the point of view of molecular devices that would operate via photons, electrons, or ions, thus defining fields of molecular photonics, electronics, and ionics. Introduction of photosensitive groups yields photoactive receptors for the design of light-conversion and charge-separation centers. Redox-active polyolefinic chains represent molecular wires for electron transfer through membranes. Tubular mesophases formed by stacking of suitable macrocyclic receptors may lead to ion channels. Molecular self-assembling occurs with acyclic ligands that form complexes of double-helical structure. Such developments in molecular and supramolecular design and engineering open perspectives towards the realization of molecular photonic, electronic, and ionic devices that would perform highly selective recognition, reaction, and transfer operations for signal and information processing at the molecular level. 相似文献
17.
18.
Supramolecular chemistry is the chemistry of the intermolecular bond, covering the structures and functions of the entities formed by association of two or more chemical species. Molecular recognition in the supermolecules formed by receptor-substrate binding rests on the principles of molecular complementarity, as found in spherical and tetrahedral recognition, linear recognition by co-receptors, metallo-receptors, amphilic receptors and anion coordination. Supramolecular catalysis by receptors bearing reactive groups effects bond cleavage reactions as well as synthetic bond formation via co-catalysis. Lipophilic receptor molecules act as selective carriers for various substrates and allow the setting up of coupled transport processes linked to electron and proton gradients or to light. Whereas endo-receptors bind substrates in molecular cavities by convergent interactions, exo-receptors rely on interactions between the surfaces of the receptor and the substrate; thus new types of receptors such as the metallonucleates may be designed. In combination with polymolecular assemblies, receptors, carriers and catalysts may lead to molecular and supramolecular devices, defined as structurally organized and functionally integrated chemical systems built on supramolecular architectures. Their recognition, transfer and transformation features are analyzed specifically from the point of view of molecular devices that would operate via photons, electrons or ions, thus defining the fields of molecular photonics, electronics and ionics. Introduction of photosensitive groups yields photoactive receptors for the design of light conversion and charge separation centres. Redox active polyolefinic chains represent molecular wires for electron transfer through membranes. Tubular mesophases formed by stacking of suitable macrocyclic receptors may lead to ion channels. Molecular self-assembling occurs with acyclic ligands that form complexes with a double helical structure. Such developments in molecular and supramolecular design and engineering open perspectives towards the realization of molecular photonic, electronic and ionic devices, that would perform highly selective recognition, reaction and transfer operations for signal and information processing at the molecular level. 相似文献
19.
以对羟基苯甲酸(4-HBA)为模板分子,4-乙烯吡啶(4-Vpy)为功能单体,制备得到了4-HBA分子印迹聚合物P(4-HBA),研究了该聚合物的分子识别机理,并与在同样条件下制备的水杨酸(SA)分子印迹聚合物P(SA)进行了分子识别能力的比较。结果表明:P(SA)比P(4-HBA)具有更好的分子识别能力。这是由于SA的酸性较4-HBA强,因此与碱性功能单体4-Vpy之间的静电作用更强,从而得到的复合物更稳定。本实验结果证明:功能单体与模板分子形成稳定的复合物是得到分子识别能力高的模板聚合物的前提条件。本文将有助于对分子印迹的过程以及分子印迹聚合物分子识别机理的进一步理解,并且对于根据模板分子的性质预测MIP的分子识别能力也将具有一定的指导意义。 相似文献
20.
芳杂环类多重氢键分子钳人工受体对中性分子的识别性能研究 总被引:3,自引:1,他引:2
根据多点氢键识别原理,设计合成了新的分子钳受体1~6。研究了其对巴比妥 、尿素、二苯甲酮、戊二酰亚胺等中性分子的识别性能。用差紫外光谱法测定了结 合常数和自由能变化(ΔG)。结果表明,所有分子钳受体与所考察的客体分子均 形成1:1型超分子配合物,识别作用的推动力主要为多重氢键的协同作用。讨论了 主客体间尺寸/形状、几何互补等因素对形成超分子配合物的影响。并利用~1H NMR、计算机模拟作辅助手段对实验结果和现象进行了解释。 相似文献