共查询到20条相似文献,搜索用时 94 毫秒
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为了全面提高后MOOC时期的高职院校分析化学课程教学质量,提出了基于SPOC的分析化学课程混合式教学模式。首先分析了高职学生的特点和分析化学课程教学中的主要问题;然后根据基于SPOC的混合式教学模式构建流程,依次阐述了课程分析、整体设计、资源开发、教学过程和评价考核设计的原则与思路;最后探讨了基于翻转课堂的分析化学课程混合式教学环境与实施过程。 相似文献
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设计不同维度的课程任务学习单,并将自主探究、协作交流等学习模式引入物理化学实验的实践教学,深入探讨了物理化学实验课程实施翻转课堂的教学模式的研究。整个教学环节包括:课前资源导学、课内知识拓展、课后成效评价。实践表明,翻转课堂有利于提高学生的知识内化能力、分析解决问题能力、合作交流能力以及自学能力,尤其是文献调研的能力有显著提升,该模式取得了较好的教学效果。 相似文献
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以糖类物质旋光度的测定为例,探索了翻转教学在医学院校基础有机化学实验教学中的应用。包括设计任务书、制作教学视频及文档、查找相关文献、课堂活动、教学总结及反思等多个环节。实践表明,翻转课堂在实验教学中的应用,改善了课前预习流于形式的状况,培养了学生主动学习的能力,激发了医学专业学生对基础有机化学实验的学习兴趣。 相似文献
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以"中药制剂检验技术"课程为例,在课前、课内、课后3个阶段,从理论和实践的角度探讨了如何利用N-CLASS网络平台构建和实施高职药品检验类课程的翻转课堂。结果表明,在药品检测类课程中,利用信息技术构建的翻转课堂不仅能够激发学生学习的主动性和学习兴趣,同时也培养了独立学习和协作学习的能力,明显提升了教学效果。 相似文献
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通过翻转课堂与传统课堂在学习目标与教学流程上的对比,详细阐述了"原电池"翻转课堂的教学设计特点与实践研究过程,即课前利用微视频和学习单自主学习形成基本概念,课堂上通过解决问题实现重要概念内化,课后通过开放性问题体验原电池的价值。实践结果显示,"原电池"翻转课堂教学设计与实践能够更好地促进学生的发展,并在一定程度上优于传统课堂教学。 相似文献
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在国内外翻转课堂相关文献对比和教育游戏特点分析基础上,尝试进行了基于教育游戏的高中化学“原电池的设计”的翻转课堂教学设计,利用教学游戏,充分调动学生的学习兴趣,提高翻转课堂课前学习效率。 相似文献
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An efficient approach to the synthesis of highly congested di, penta and hexacyclic pyrazoles as well as imidazole fragment containing novel heterocyclic molecule has been developed through a carbanion induced transformation of suitably functionalized 2H-pyran-2-ones, benzo[h]chromene and thiochromeno[4,3-b]pyrans. Due to the presence of fluorescence, we report their prime application metal sensor as off/on switching in ferric ions. 相似文献
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Uroš Grošelj Mojca Žorž Amalija Golobič Branko Stanovnik Jurij Svete 《Tetrahedron》2013,69(52):11092-11108
A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives. 相似文献
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The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp3)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp2)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp2)?H and aliphatic 1,5- and 1,6-C(sp3)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp3)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp2)?H insertion. 相似文献
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N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%). 相似文献
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An efficient tandem approach for the selective synthesis of 4,5-dihydroimidazo[1,5-a]quinoxalines 6a–g and imidazo[1,5-a]quinoxalines 7a–h by the reaction of 2-imidazolyl anilines 4a–c with aryl aldehydes 5a–k under mild reaction conditions is described. Introduction of electron releasing alkyl groups in substrates 4a–b was found to be instrumental for the success of the reaction. 相似文献
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The Diels-Alder reactivity of 1,2-heteroborines (H4C4B(H)X, X?=?NH, PH, AsH; O, S, Se) has been computationally explored by means of Density Functional Theory (DFT) calculations. The influence of the HB?=?X fragment on the reactivity of the system has been quantitatively analyzed in detail by means of the so-called Activation Strain Model (ASM) of reactivity. It is found that the interaction between these species and the dienophile is significantly stronger than that computed for their all-carbon isoelectronic counterpart, benzene. In addition, the strain energy plays a key role in the observed reactivity trends. The role of the aromaticity strength of these heteroarenes on the reactivity is also assessed. 相似文献
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Xi-Liu YunWen-Ying Bi Jian-Hui HuangYu Liu Daisy Zhang-NegrerieYun-Fei Du Kang Zhao 《Tetrahedron letters》2012,53(38):5076-5080
A variety of N-aryl and N-alkyl carbazolones were conveniently achieved in good to high yields via Pd2(dba)3-mediated intramolecular coupling of N-substituted α-iodo enaminones under microwave irradiation. The Pd(0)-catalyzed cyclization was found to proceed favorably with the more electron-deficient phenyl ring during the reactions involving unsymmetrical N,N-diaryl α-iodo enaminones. This unique property enables the construction of carbazolone skeleton containing nitro substituted benzenoid ring. 相似文献
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Shashikant U. Dighe Surya K. Samanta Shivalinga Kolle Sanjay Batra 《Tetrahedron》2017,73(17):2455-2467
An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y1 and Y2. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones. 相似文献
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In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates. 相似文献
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Both substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles and 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles have been synthesized by the 3+2 intramolecular dipolar cycloaddition of nitrilimines to alkynes. This cyclization has been extended to more versatile 3-bromo derivatives by the use of alkynylbromides as dipolarophiles. 相似文献