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新型2-(2'-取代亚肼基)-1,3-二硫杂环戊烷衍生物的合成和菌活性研究 总被引:1,自引:0,他引:1
通过结构改造并结合活性基团的拼接合成了11个未见文献报道的新型2-(2'-取代亚肼基)-1,3-二硫杂环戊烷类化合物,所有的目标物的结构都经HNMR,MS,IR和元素分析证实,选择了其中5个化合物对7种细菌进行了抑菌活性1测试,并与市售农药20%三环唑、70%威尔达甲托的抑菌活性进行对比,发现它们比市售农药有更为广泛的杀菌谱,对照农药只对金黄色葡萄球菌有良好的抑菌作用而这些化合物则对所选择的七个菌种均有良好的抑菌作用.其中化合物2-(对氟苯氧乙酰亚肼基)-1,3-二硫杂环戊烷(4c)的杀菌谱很广,它对金色葡萄球菌、大肠杆菌、白色念珠菌的抑杀活性都很好. 相似文献
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新型2-(2'-取代亚肼基)-1,3-二硫杂环戊烷衍生物的合成和菌活性研究 总被引:3,自引:0,他引:3
通过结构改造并结合活性基团的拼接合成了11个未见文献报道的新型2-(2'-取代亚肼基)-1,3-二硫杂环戊烷类化合物, 所有的目标物的结构都经1H NMR, MS, IR和元素分析证实, 选择了其中5个化合物对7种细菌进行了抑菌活性测试, 并与市售农药20%三环唑、70%威尔达甲托的抑菌活性进行对比, 发现它们比市售农药有更为广泛的杀菌谱, 对照农药只对金黄色葡萄球菌有良好的抑菌作用而这些化合物则对所选择的七个菌种均有良好的抑菌作用. 其中化合物2-(对氟苯氧乙酰亚肼基)-1,3-二硫杂环戊烷(4c)的杀菌谱很广, 它对金色葡萄球菌、大肠杆菌、白色念珠菌的抑杀活性都很好. 相似文献
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研究开发新的抗癌、抗病毒药物的有效途径之一是设计、合成以及生物活性评价新型结构的核苷类似物。根据核苷结构的特点,核苷类似物的研究包括碱基改造和糖基改造两个方面。现已报道的糖基结构改造的核苷类似物基本分为含氧杂环、碳环、其它杂环(如:含氮杂环,含硫杂环等)以及无环类似物等(1)。由于可利用天然单糖作为原料,获得光活性的含多个手性碳的含氧杂环核苷类似物相对较容易;而其它杂环的光活性核苷类似物,则因涉及至少两个手性碳原子的引入,合成难度增加。本文首次报道了用光活性的苹果酸和酒石酸为起始原料,成功地合成了光活性多羟基氮杂核苷类似物(Ⅰ,Ⅱ)。 相似文献
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用三氯硫磷与β-羟基乙胺类化合物在四氢呋喃溶液中反应,再加入苯酚(胺),一锅反应合成了一系列2-取代苯氧(氨)基-1,3,2-氧氮磷杂环戊烷,并对其波谱性质进行了讨论. 相似文献
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1,3,2-氧氮磷杂环戊烷衍生物(Ⅱ)——2-二乙氨基-3-取代甲酰基-1,3,2-氧氮磷杂环戊烷衍生物的合成及其性质研究 总被引:1,自引:1,他引:0
用六乙基亚磷酰胺与N-(β-羟基乙基)取代甲酰胺进行成环反应,合成了一系列新的有机磷杂环化合物,2-二乙氨基-3-取代甲酰基-1,3,2-氧氮磷杂环戊烷,然后与硫作用生成2-硫逐代衍生物,亦可不经分离一步完成上述反应。 相似文献
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Carbon-13 nmr spectra of several 1,3-oxathiolane, 1,3-oxathiolane-3-oxide and 1,3-oxathiolane-3,3-dioxide derivatives are reported. Relationships between some stereochemical features and chemical shift are discussed. 相似文献
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S. V. Nikolaeva V. V. Zorin S. S. Zlotskii D. L. Rakhmankulov 《Chemistry of Heterocyclic Compounds》1986,22(2):210-214
The homolytic addition of 1,3-oxathiolane to olefins takes place with the formation of 2-substituted 1,3-oxathiolanes and insignificant amounts of functional derivatives of sulfides.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 259–263, February, 1986. 相似文献
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N. A. Keiko E. A. Funtikova L. G. Stepanova Yu. A. Chuvashev A. I. Albanov M. G. Voronkov 《Russian Journal of Organic Chemistry》2001,37(12):1693-1699
The reaction between 2-alkoxypropenals and 2-mercaptoethanol was studied at 20 and 60°C by means of 1HNMR and GC-MS methods. Under kinetically controlled conditions (20°C, 7-30 days) with no catalyst the addition of 2-mercaptoethanol to 2-alkoxypropenals occurs along Markownikoff rule. The arising 2'-hydroxyethylthio-2-alkoxypropanal undergoes isomerization into the 2-hydroxy-3-alkoxy-3-methyl-1,4-oxathiane that at heating in the presence of catalytic amounts of acids is converted into 2-methyl-2-formyl-1,3-oxathiolane. The reaction of 2-alkoxypropenals with 2-mercaptoethanol at heating (60°C, 3 h) in the presence of acids affords 2-methyl-2,2'-bi(1,3-oxathiolane) even at 2-mercaptoethanol deficit. At the double excess of the latter the 2-methyl-2,2'-bi(1,3-oxathiolane) was obtained in quantitative yield. The presumable schemes of conversion of 2-hydroxy-3-alkoxy-3-methyl-1,4-oxathiane into 2-methyl-2-formyl-1,3-oxathiolane and 2-acetyl-1,3-oxathiolane are discussed. 相似文献
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The 13C NMR chemical shifts for 4-oxo-1,3-dioxolane (1) and its all methyl-substituted derivatives (2-10) as well as for 5-oxo-1,3-oxathiolane (11) and its nine alkyl-substituted derivatives (12-20) are reported. The magnitude and variety of the substituent effects are in accordance with the envelope conformations in which the oxygen or sulfur atom locates at the tip of the envelope as postulated on the basis of earlier data. 相似文献
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Daniel J. Pasto 《Journal of heterocyclic chemistry》1969,6(2):175-179
The mass spectral fragmentation patterns of 1,3-oxathiolane and 2-, 4-, and 5-substituted oxathiolanes have been recorded. The various fragments have been identified by high-resolution mass spectrometry when appropriate. Of the five possible modes of ring cleavage to produce two- and three-atom fragments only two modes are actually observed. The mode of fragmentation of the 1,3-oxathiolane ring differs from that proposed for 1,3-dioxalane and in all probability occurs in multistep processes. 相似文献
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The first palladium-catalyzed ring-expansion reaction of 2-vinylthiiranes with heterocumulenes to form sulfur-containing five-membered-ring heterocycles is described. This regioselective reaction requires 5 mol % of Pd(2)(dba)(3).CHCl(3) and 10 mol % of bidendate phosphine ligand (dppp, BINAP), at 50-80 degrees C, in THF. The reaction of 2-vinylthiiranes with carbodiimides, isocyanates, and ketenimines affords 1,3-thiazolidine derivatives, whereas the reaction with diphenylketene or isothiocyanates results in the formation of 1,3-oxathiolane or 1,3-dithiolane compounds in good to excellent isolated yields and in up to 78% ee. 相似文献
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Positively charged lipids of the 1,3-oxathiolane series were synthesized by interaction of 2-pentadecyl-5-tosyloxymethyl- or -5-iodomethyl-1,3-oxathiolane with 2-(N,N-dimcthyl-amino)ethanol.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 2347–2349, September, 1996. 相似文献
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M. D. Khanova R. M. Sultanova S. L. Khursan V. A. Dokichev Yu. V. Tomilov 《Russian Chemical Bulletin》2006,55(8):1464-1469
Methoxycarbonylcarbene generated by catalytic decomposition of methyl diazoacetate in the presence of Rh2(OAc)4, is regioselectively inserted into the C(2)-O bond of 3-alkyl-2-phenyl-1,3-oxazolidines and into the C(2)-S bond of 2-phenyl-1,3-oxathiolane.
Study by the competitive reaction method demonstrated that the relative reactivity toward the insertion of the methoxycarbonylcarbene
fragment into the C-heteroatom bond increases in the series of 1,3-dioxolane, 1,3-oxazolidine, and 1,3-oxathiolane.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1411–1415, August, 2006. 相似文献
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G. A. Kalabin B. A. Trofimov S. V. Amosova V. K. Voronov 《Chemistry of Heterocyclic Compounds》1975,11(5):529-533
The 1H and 13C NMR spectra of 2,5-dimethyl-4-methylene-1,3-oxathiolane were analyzed by comparison of the calculated and experimental parameters with the aid of a paramagnetic shift reagent. The data obtained from the NMR spectra were used for the establishment of the structures of the products of isomerization and alcoholysis of 2,5-dimethyl-4-methylene-1,3-oxathiolane. 相似文献
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The synthesis of new liquid-crystalline materials containing a five membered heteroalicyclic ring is described. The trans 2,4-disubstituted 1, 3-oxathiolane derivatives exhibit lower clearing temperatures and melting points than the analogous six membered 1, 3-oxathiane compounds. However the mesophase stability of the 1, 3-oxathiolane derivatives is superior to that of comparable cyclopentane derivatives. 相似文献