曲面相机阵列多分辨成像方法

针对现有成像系统因数据冗余而无法兼顾大视场、高分辨、高效性的问题,结合人眼视网膜变分辨成像和并列式复眼成像原理,设计一种多分辨率成像的复合仿生成像系统.该成像系统按照球面和平面兼顾的曲面布局方式,利用11个相机镜头构建相机阵列,组成了四个等级分辨率的子眼拍摄模块.通过物距100 m的远景实验和物距10 m的近景实验发现,该系统在实现高分辨成像的同时,获得总视场达150.8°×37.8°.多分辨率成像实验结果表明,该系统获取的图像的分辨率从中心视场到边缘视场逐渐降低,并且相较于中心清晰全视场成像,四级分辨率成像的拼接图像数据量减少了17.2倍的数据冗余.     

Infrared super-resolution imaging method based on retina micro-motion

With the wide application of infrared focal plane arrays (IRFPA), military, aerospace, public security and other applications have higher and higher requirements on the spatial resolution of infrared images. However, traditional super-resolution imaging methods have increasingly unable to meet this requirement in technology. In this paper, we adopt the achievement that the human retina micro-motion is the important reason why the human has the hyperacuity ability. Based on the achievement, we bring forward an infrared super-resolution imaging method based on retina micro-motion. In the method, we use the piezoelectric ceramic equipment to control the infrared detector moving variably within a plane parallel to the focal plane. The motion direction is toward each other into a direction of 90°. In the four directions of the movement, we get four sub-images and generate a high spatial resolution infrared image by image interpolation method. In the process of the shifting movement of the detector, we set the threshold of the detector response and record the response time difference when adjacent pixel responses are up to the threshold. By the method, we get the object’s edges, enhance them in the high resolution infrared image and get the super-resolution infrared image. The experimental results show that our proposed super-resolution imaging methods can improve the spatial resolution of the infrared image effectively. The method will offer a new idea for the super-resolution reconstruction of infrared images.     

Adaptive optics optical coherence tomography for retina imaging

When optical coherence tomography (OCT) is used for human retina imaging, its transverse resolution is limited by the aberrations of human eyes. To overcome this disadvantage, a high resolution imaging system for living human retina, which consists of a time domain OCT system and a 37-elements adaptive optics (AO) system, has been developed. The AO closed loop rate is 20 frames per second, and the OCT has a 6.7-μm axial resolution. In this paper, this system is introduced and the high resolution imaging results for retina are presented.     

干涉型计算层析成像光谱仪的图像重建

针对干涉型计算层析成像光谱仪(CTII)提出了一种光谱图像数据立方体的重建方法。干涉型计算层析成像光谱仪是一种将空间调制傅里叶变换成像光谱仪(FTIS)的原理与计算层析成像光谱仪(CTIS)的原理相结合的一种新型成像光谱仪,具有高通量、高光谱分辨力以及高空间分辨力的特点。分析和讨论了干涉型计算层析成像光谱仪的工作原理以及获取图像的特征,介绍了光谱图像数据立方体的重建方法。根据多角度投影数据的特点提出采用卷积反投影计算层析成像图像重建算法,给出了图像重建步骤以及相应的数学表达式。对D65光源照明条件下的396×396像素目标进行了仿真实验,投影角度为0~180°,步长为0.5°,列出了仿真实验部分结果。实验结果验证了干涉型计算层析成像光谱仪及其图像重建算法的可行性。     

Design of object surveillance system based on enhanced fish-eye lens

A new method is proposed for the object surveillance system based on the enhanced fish-eye lens and the high speed digital signal processor （DSP）. The improved fish-eye lens images an ellipse picture on the charge-coupled device （CCD） surface, which increases both the utilization rate of the 4：3 rectangular CCD and the imaging resolution, and remains the view angle of 183° The algorithm of auto-adapted renewal background subtraction （ARBS） is also explored to extract the object from the monitoring image. The experimental result shows that the ARBS algorithm has high anti-jamming ability and high resolution, leading to excellent object detecting ability from the enhanced elliptical fish-eye image under varies environments. This system has potential applications in different security monitoring fields due to its wide monitoring space, simple structure, working stability, and reliability.     

用于活体人眼视网膜观察的自适应光学成像系统

利用自适应光学技术,研制了两套活体人眼视网膜高分辨力成像系统,在实时校正人眼波前误差的基础上,实现活体人眼视网膜细胞尺度的高分辨力成像。这两套系统分别采用19和37单元小型压电变形反射镜作为波前校正元件,哈特曼-夏克(Hartmann-Shack)波前传感器测量波前误差,用眼底反射的半导体激光作为波前探测的信标。在用计算机控制自适应光学系统实现人眼波前误差校正后,触发闪光灯照明视网膜,用CCD相机记录视网膜的高分辨力图像。校正后的残余波前误差的均方根值已分别小于1／6和1／10波长,相当于视网膜上成像分辨力分别为3．4μm和2．6μm,接近衍射极限。试验表明37单元系统的成像质量更好。     

Retinal imaging with adaptive optics

Imaging the human retina in vivo is affected by the eye's natural aberrations, which limit the resolution of retinal images. Measuring these aberrations, including the high order ones, is possible using wavefront sensing techniques. A review of the rapid progress in this field is given. Once the aberrations are known, adaptive optics methods, developed for astronomical observing in the past 15 years, can be applied in order either to improve retinal imaging or to give hyper-vision to the subject. Progress in this domain is reviewed, and some original results are reported with a new instrument. Future applications are discussed, including a possible three-dimensional, high-resolution method to image the human retina in vivo.     

Determining the imaging plane of a retinal capillary layer in adaptive optical imaging

Even in the early stage,endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μm.However,the fundus cameras used in clinic diagnosis can only obtain images of vessels larger than 20 μm in diameter.The human retina is a thin and multiple layer tissue,and the layer of capillaries less than10 μm in diameter only exists in the inner nuclear layer.The layer thickness of capillaries less than 10 μm in diameter is about 40 μm and the distance range to rodcone cell surface is tens of micrometers,which varies from person to person.Therefore,determining reasonable capillary layer(CL) position in different human eyes is very difficult.In this paper,we propose a method to determine the position of retinal CL based on the rodcone cell layer.The public positions of CL are recognized with 15 subjects from 40 to 59 years old,and the imaging planes of CL are calculated by the effective focal length of the human eye.High resolution retinal capillary imaging results obtained from 17 subjects with a liquid crystal adaptive optics system(LCAOS) validate our method.All of the subjects' CLs have public positions from 127 μm to 147 μm from the rodcone cell layer,which is influenced by the depth of focus.     

高速线扫描共焦检眼镜

高速线扫描共焦检眼镜使用线光束照明眼底视网膜,同时利用线阵CCD对视网膜平面的单次散射线光束探测成像。系统光学放大率为7倍,横向分辨率小于10μm,对于58kHz线频的1024pixel×512pixel成像模式,成像帧频高达110frame/s。该系统实现了高分辨率、高帧频模拟人眼实验图像的获取。     

In vivo biomicroscopy with ultrasound

We propose the use of inverse scattering theory methods to analyse high frequency ultrasound reflection data to provide high resolution images of living tissue. Conventional ultrasound imaging uses the pulse-echo method which can only resolve structures which are large compared to the wavelength of the ultrasound. Inverse scattering analysis, on the other hand, can image details as small as a quarter wavelength. This makes possible a significant improvement in resolution and has many potential applications in the detection and study of disease. We report here results obtained using this method to produce images of the retina, where we were able to resolve details as small as 50 micron in a 300 micron layer.     

Fast voice-coil scanning optical-resolution photoacoustic microscopy

We developed a photoacoustic imaging system that has real-time imaging capability with optical resolution. The imaging system is capable of scanning at 20 Hz over a 9 mm range and up to 40 Hz over a 1 mm scanning range. A focused laser beam provides a lateral resolution of 3.4 μm as measured in an optically nonscattering medium. Flows of micrometer-sized carbon particles or whole blood in a silicone tube and individual red blood cells (RBCs) in mouse ear capillaries were also imaged in real time, demonstrating the capability to image highly dynamic processes in vivo at a micrometer-scale resolution.     

Magnetic resonance image enhancement using highly sparse input

Lately, the Magnetic Resonance scans have struggled with its own inherent limitations, such as spatial resolution as well as long examination times. In this paper, a novel, rapid compressively-sensed magnetic resonance high resolution image resolution algorithm is presented. This technique addresses these two key issues by employing a highly-sparse sampling scheme and super-resolution reconstruction (SRR) method. Due to highly challenging requirements for the accuracy of diagnostic images registration, the presented technique exploits image priors, deblurring, parallel imaging, and a discrete dense displacement sampling for the deformable human body and motion analysis. The clinical trials as well as phantom based studied have been conducted. It has been proven that the proposed algorithm is able to enhance image spatial resolution, reduce motion artefacts and scan times.     

一种新型的液闪阵列成像屏空间分辨特性

针对低强度射线成像,自主研制了一种像元为0.1 mm高探测效率的液闪阵列屏.为此,基于倾斜刀口边缘响应的测量原理,建立了理论模拟方法和实验研究方法,对该液闪阵列屏开展了空间分辨性能研究.通过理论模拟,给出了液闪阵列屏在14 MeV中子和1.25 MeV伽马射线激发下的调制传递函数,并与像元为0.1,0.3和0.5 mm的闪烁纤维阵列屏进行了理论对比.在60Co伽马射线源上,对液闪阵列屏和像元为0.3和0.5 mm的两种国产闪烁纤维阵列屏进行了调制传递函数实测研究.理论模拟和实验结果一致,均表明液闪阵列的空间特性优于闪烁纤维阵列屏,而且具有更好的均匀性,对1.25 MeV伽马,空间分辨接近0.9 lp/mm,而其他两种纤维阵列屏仅达到0.5 lp/mm,对于14 MeV中子,液闪阵列屏的空间分辨可达到1.8 lp/mm.     

Simulated human eye retina adaptive optics imaging system based on a liquid crystal on silicon device

In order to obtain a clear image of the retina of model eye, an adaptive optics system used to correct the wave-front error is introduced in this paper. The spatial light modulator that we use here is a liquid crystal on a silicon device instead of a conversional deformable mirror. A paper with carbon granule is used to simulate the retina of human eye. The pupil size of the model eye is adjustable (3--7mm). A Shack-Hartman wave-front sensor is used to detect the wave-front aberration. With this construction, a value of peak-to-valley is achieved to be 0.086Λ, where Λ is wavelength. The modulation transfer functions before and after corrections are compared. And the resolution of this system after correction (69lp/m) is very close to the diffraction limit resolution. The carbon granule on the white paper which has a size of 4.7μm is seen clearly. The size of the retina cell is between 4 and 10μm. So this system has an ability to image the human eye's retina.     

三反射式柱面光学系统设计及优化

针对传统单片柱透镜和柱面反射镜成像光束不理想以及视场通常小于1°,提出并设计了一种三反射式柱面结构.对柱面光线追迹及单片柱面镜成像进行了深入分析,分别设计了三反射式圆柱面和二次曲线柱面系统,提出了一种基于抛物柱面镜理想线聚焦的新型像差优化方法,使其在子午面方向各视场调制传递函数得到最佳优化,并达到成像光谱仪等在狭缝方向卜高空间分辨率要求.其子午面总视场均达到了3°,在45 lp/mm分辨率条件下,边缘视场子午面方向的调制传递函数分别优于0.2和0.6.     

基于量子级联激光器照明的高对比度红外内窥成像

对单丝直径为20μm,12×9阵列方形面阵的Ge-As-Te-Se组分光纤束进行了测试,并开展红外成像研究。利用5~11μm连续可调谐红外量子级联激光器作为光源,对光纤束损耗进行检测,传输损耗平均为1 dB/cm。设计并加工了基于像方远心成像的紧凑型物镜,总长13.6 mm,直径6 mm,最终实现了2 mm×2 mm视场内100μm分辨率传像。分别在量子级联激光器和非相干黑体光源的照明下,进行了环境温度对成像对比度影响的研究,结果表明,在环境温度较高(>40℃)的条件下,基于量子级联激光器照明可实现高对比度内窥成像。本文对于深入开展红外生物效应研究具有指导意义和实用价值。     

基于灰度投影法运动估计的成像CCD平移补偿法

为了提高成像质量,得到高分辨率的图像,通过对灰度投影法进行分析,提出一种基于灰度投影法运动估计的成像CCD平移补偿法,给出其系统结构图。该方法采取只平移成像CCD,探测CCD固定,即在成像CCD补偿位移量的过程中,探测CCD不补偿位移,探测CCD在成像开始的第一帧为全局参考帧,其他帧与之比较来获得位移量。验证了分辨率标板在各种运动情况下系统的补偿效果,对拍摄的实物图像进行恢复,结果证明：该补偿法对慢速运动图像和随机振动图像具有较高的恢复能力。     

人眼视网膜成像自适应光学系统设计

设计一套基于液晶空间光调制器的人眼视网膜成像自适应光学系统,以获得高分辨率视网膜图像,并且使该系统实现体积小,功耗低,成本低等优点.采用夏克-哈特曼探测器和基于硅基板上的液晶器件分别作为波前探测器和波前校正器.系统采用双对准光源以主观方式来使人眼对准,近红外光探测成像以减小对人眼的刺激.使人眼对有限距离对焦,以减小离焦对成像的影响,使该系统既可用于正常眼,又可用于近视眼.用ZEMAX软件对系统进行了模拟分析,认为该系统可获得高于3 μm的视网膜分辨率,该系统设计是合理可行的.     

超分辨率活体人眼视网膜共焦扫描成像系统

活体人眼共焦扫描成像系统的分辨率受到人眼像差、数值孔径和探测针孔尺度的限制,本文设计了一套超分辨活体人眼视网膜共焦扫描系统,采用自适应光学技术探测并校正人眼像差,结合光学超分辨技术提高系统分辨率,补偿有限尺度针孔对分辨率的影响,并获得活体人眼的实时、高分辨图像. 关键词： 超分辨 共焦扫描光学显微术 眼科光学 自适应光学     

亚像元几何图像成像与超分辨恢复算法

随着光学成像到光电数字成像的转变,如何提高CCD的几何分辨率已成为研制高分辨光电成像系统亟待解决的问题。从研究现状入手,给出了现有算法并指出不足之处`,建立了亚像元超分辨成像数学模型,提出了亚像元的CCD几何超分辨方法:将两片线阵CCD集成在同一器件中,在线阵方向上错开半个像元,同时读出时间减半,最终交织重组图像数据,合成高分辨率图像。利用MATLAB软件对双线性插值方法及亚像元成像方法进行了仿真,并定性定量地分析了两种方法的效果。结果表明:亚像元方法合成图像分辨率约为低分辨率图像的2倍,且两组仿真图像中的峰值信噪比比双线性插值图像分别高出1.4864dB和2.2070dB,该方法可以显著地减轻欠采样引起的图像模糊,且实时性优于双线性插值方法。