纵向数据混合效应模型的统计分析

本文研究了Tao等人在1999年提出的半参数混合效应模型,在不假设随机效应服从正态分布的条件下,用傅立叶变换的方法构造了随机效应的光滑非参数密度估计,给出了密度估计的公式,研究了其渐近性质,还构造了半参数混合效应模型中参数的估计方法并研究了其大样本性质.     

纵向数据半参数混合效应模型中的估计方法

本文将Tao等(1999)提出的线性混合效应模型推广为半参数混合效应模型,给出了模型参数、回归函数和随机效应密度的估计,并研究了估计的渐近性质.统计模拟表明我们给出的估计方法是可行的.     

半参数线性混合效应模型的联合变量选择

多数基于线性混合效应模型的变量选择方法分阶段对固定效应和随机效应进行选择,方法繁琐、易产生模型偏差,且大部分非参数和半参数的线性混合效应模型只涉及非参数部分的光滑度或者固定效应的选择,并未涉及非参变量或随机效应的选择。本文用B样条函数逼近非参数函数部分,从而把半参数线性混合效应模型转化为带逼近误差的线性混合效应模型。对随机效应的协方差矩阵采用改进的乔里斯基分解并重新参数化线性混合效应模型,接着对该模型的极大似然函数施加集群ALASSO惩罚和ALASSO惩罚两类惩罚,该法能实现非参数变量、固定效应和随机效应的联合变量选择,基于该法得出的估计量也满足相合性、稀疏性和Oracle性质。文章最后做了个数值模拟,模拟结果表明,本文提出的估计方法在变量选择的准确性、参数估计的精度两个方面均表现较好。     

半参数混合效应模型中的估计及其强相合性

将Tao等(1999)提出的线性混合效应模型推广为半参数混合效应模型,给出了模型参数、回归函数和随机效应密度的估计,并研究了估计的强相合性及部分强相合速度.统计模拟表明我们给出的估计方法是可行的.     

部分线性模型的随机约束岭估计

研究了部分线性回归模型附加有随机约束条件时的估计问题.基于Profile最小二乘方法和混合估计方法提出了参数分量随机约束下的Profile混合估计,并研究了其性质.为了克服共线性问题,构造了参数分量的Profile混合岭估计,并给出了估计量的偏和方差.     

变系数部分线性模型的加权随机约束s-K估计

研究随机约束条件下半参数变系数部分线性模型的参数估计问题,当回归模型线性部分变量存在多重共线性时,基于Profile最小二乘方法、s-K估计和加权混合估计构造参数向量的加权随机约束s-K估计,并在均方误差矩阵准则下给出新估计量优于s-K估计和加权混合估计的充要条件,最后通过蒙特卡洛数值模拟验证所提出估计量的有限样本性质.     

部分线性变系数模型改进的加权混合Profile-Liu估计

研究半参数部分线性变系数模型的有偏估计,当回归模型参数部分自变量存在多重共线性时,在随机线性约束条件下,融合Profile最小二乘估计、加权混合估计和Liu估计构造回归模型参数分量改进的加权混合Profile-Liu估计,并在一定正则条件下证明估计量的渐近性质,最后利用蒙特卡洛数值模拟验证所提出估计量的有限样本表现性.     

半参数广义线性混合效应模型的估计及其渐近性质

半参数广义线性混合效应模型在心理学、生物育种、医学等领域有广泛的应用. Zhang(1998)用最大惩罚似然函数的方法(MPLE)对模型的参数和非参数部分进行了估计, 而Zhang (1998) MPLE方法只适用于正态数据模型. 对于泊松等常用的模型, 常的方法是将随机效应看作缺失数据, 再引入EM算法. 本文基于McCulloch 1997)提出的MCNR算法, 此算法推广到半参数广义线性混合效应模型中并得到相应的估计算法. 于非参数部分, 本文采用P样条拟合并利用GCV方法选取光滑参数, 时证明了所得估计的相合性和渐近正态性. 最后, 过模拟和实例与其它算法作比较验证本文估计方法的有效性.     

线性混合效应模型中随机效应密度的非参数估计

对于Tao等(1999)提出的一类线性混合效应模型,构造了随机效应密度的非参数估计,并证明了此估计量具有渐近无偏性.     

强混合样本下最近邻密度估计的渐近正态性

研究了α-混合样本下最近邻密度估计的渐近性质,证明了估计的渐近正态性并且给出了其渐近方差的显式表达式,由此构造了α-混合样本下概率密度的渐近置信区间.     

一类零膨胀半参数混合效应模型的惩罚似然估计

本文将半参数线性混合效应模型推广应用到一类具有零膨胀的纵向数据或集群数据的研究中,提出了一类新的半参数混合效应模型,然后利用广义交叉核实法选取光滑参数,通过最大惩罚似然函数方法与EM算法给出了模型参数部分与非参数部分的估计方法,最后,通过模拟和实例说明了本文方法的有效性.     

Inference for the treatment effects in two sample problems with right-censored and length-biased data

In the study of comparing treatment effects, the data structures of two samples may be different. In this paper, we develop a unified semiparametric estimating equation approach to estimate various types of treatment effects with right-censored and length-biased data based on a semiparametric two-sample model. The large sample properties of the proposed estimators are derived and numerical studies are conducted to illustrate the proposed methods.     

Mixtures of semiparametric varying coefficient models for longitudinal data with nonignorable dropout

Informative dropout often arise in longitudinal data. In this paper we propose a mixture model in which the responses follow a semiparametric varying coefficient random effects model and some of the regression coefficients depend on the dropout time in a non-parametric way. The local linear version of the profile-kernel method is used to estimate the parameters of the model. The proposed estimators are shown to be consistent and asymptotically normal, and the finite performance of the estimators is evaluated by numerical simulation.     

A semiparametric method for estimating nonlinear autoregressive model with dependent errors

The first-order nonlinear autoregressive model is considered and a semiparametric method is proposed to estimate regression function. In the presented model, dependent errors are defined as first-order autoregressive AR(1). The conditional least squares method is used for parametric estimation and the nonparametric kernel approach is applied to estimate regression adjustment. In this case, some asymptotic behaviors and simulated results for the semiparametric method are presented. Furthermore, the method is applied for the financial data in Iran’s Tejarat-Bank.     

Efficient estimation of a varying-coefficient partially linear binary regression model

This article considers a semiparametric varying-coefficient partially linear binary regression model. The semiparametric varying-coefficient partially linear regression binary model which is a generalization of binary regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. A Sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. One of our main objects is to estimate nonparametric component and the unknowen parameters simultaneously. It is easier to compute, and the required computation burden is much less than that of the existing two-stage estimation method. Under some mild conditions, the estimators are shown to be strongly consistent. The convergence rate of the estimator for the unknown smooth function is obtained, and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. Simulation studies are carried out to investigate the performance of the proposed method.     

Bayesian Semiparametric Density Estimation and Model Verification Using a Logistic–Gaussian Process

This article proposes a semiparametric model, which consists of parametric and nonparametric components, for density estimation. The parametric component represents the researcher's a priori beliefs about a likely family of density functions. The nonparametric component, which is modeled by a logistic–Gaussian process, allows the predictive distribution to deviate from the parametric family if it is inadequate. Bayesian hypothesis testing is used to examine the adequacy of the parametric model relative to the flexible alternative provided by the semiparametric model. The article presents a Markov chain Monte Carlo algorithm that efficiently handles the large number of parameters.     

Consistency and asymptotic normality of profilekernel and backfitting estimators in semiparametric reproductive dispersion nonlinear models

Semiparametric reproductive dispersion nonlinear model (SRDNM) is an extension of nonlinear reproductive dispersion models and semiparametric nonlinear regression models, and includes semiparametric nonlinear model and semiparametric generalized linear model as its special cases. Based on the local kernel estimate of nonparametric component, profile-kernel and backfitting estimators of parameters of interest are proposed in SRDNM, and theoretical comparison of both estimators is also investigated in this paper. Under some regularity conditions, strong consistency and asymptotic normality of two estimators are proved. It is shown that the backfitting method produces a larger asymptotic variance than that for the profile-kernel method. A simulation study and a real example are used to illustrate the proposed methodologies. This work was supported by National Natural Science Foundation of China (Grant Nos. 10561008, 10761011), Natural Science Foundation of Department of Education of Zhejiang Province (Grant No. Y200805073), PhD Special Scientific Research Foundation of Chinese University (Grant No. 20060673002) and Program for New Century Excellent Talents in University (Grant No. NCET-07-0737)     

Accelerated Failure Time Model for Arbitrarily Censored Data With Smoothed Error Distribution

This article develops a semiparametric procedure to estimate parameters of an accelerated failure time model. To express the density of the error distribution, we use the P-spline (B-splines with penalties) smoothing technique. To accommodate error densities with infinite support (and for other reasons) we replace the B-splines with their limits as the degree of the B-spline goes to infinity; namely, with normal densities. The spline coefficients as well as any number of regression parameters are quickly and accurately estimated via penalized maximum likelihood. The method directly provides predictive survival distributions for fixed values of covariates while allowing for left-, right-, and interval-censored data. The approach has been implemented as an R package and is applied here to the problem of predicting AIDS-free survival in the presence of interval censoring.