共查询到19条相似文献,搜索用时 328 毫秒
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惯性效应在微流控芯片中的应用 总被引:3,自引:0,他引:3
作为一种操控粒子或流体的新技术,基于流体惯性的操控技术已被应用于微流控芯片中粒子的输运、分选、聚焦及试样的混合和反应等操作,而在微尺度惯性效应基础上的惯性微流控芯片由于具有高通量、无需外场介入、低成本、易集成及微型化等众多优点,可用于解决医疗诊断、生化分析、合成化学及环境监测等领域的检测分析和微量操控问题,因此对该技术的机理及应用研究已成为目前微流控技术领域一个重要的研究热点。本文在介绍惯性微流控芯片机理及其研究进展的同时,从惯性聚焦、惯性分选及基于Dean流的微混合器和微流控光学器件等几个方面对惯性微流控芯片的最新应用研究进展进行了较为详细的介绍和分析比较。在此基础上,分析了惯性微流控芯片的局限和未来需要解决的问题。 相似文献
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微/纳米材料因其尺度的微小而具有异于宏观材料的特殊性质, 在多个领域都有着丰富的应用. 近年来, 微流控技术因其微量、高效、高通量、微型化、集成化和自动化等独特的优势在微/纳米材料的合成中引起了广泛的关注. 本综述从微反应器的结构形式及反应方式两个角度进行分类, 介绍了微流控技术在无机材料、有机材料和复合材料中的具体应用, 并对该领域未来的主要发展趋势进行了展望. 微流控技术为微/纳米材料的合成提供了新的思路和方法, 在工业生产和学术研究中都蕴含着丰富的可能性和巨大的潜力. 相似文献
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碳量子点(CQDs)呈现出的亲水性、低细胞毒性、化学及光稳定性等优异性质,使其在化学、生物医学、传感学及光电子学领域得到了广泛的关注与应用。本文重点介绍CQDs合成的最新进展,总结了宏观条件下CQDs合成的自上而下法(弧光放电、激光烧蚀、电化学等)与自下而上法(化学氧化、热分解、微波加热等),比较了不同合成方法中碳源的利用率、反应条件、产物的尺寸分布、荧光性能及应用,讨论了各种合成方法的成功之处与存在的问题。文中详细介绍了基于微反应器原理的反胶束法和模板法在CQDs尺寸可控合成领域的应用。微流控芯片技术在纳米材料合成中显现安全、高效、可控等优于宏观反应体系的优势,结合目前微流控芯片合成CQDs的研究进展,可以预期微流控芯片在不久的将来将会在CQDs的合成中得到更成功的应用。 相似文献
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微通道反应器在合成反应中的应用 总被引:4,自引:0,他引:4
微流控学(microfluidics)是在微米级结构中操控纳升至皮升体积流体的技术与科学,是近10年来迅速崛起的新交叉学科.流体在微流控芯片微米级通道中,由于尺度效应导致了许多不同于宏观体系的特点,例如分子间扩散距离短、微通道的比表面积大、传热和传质速度快等,促进了微流控芯片在有机合成反应中的发展.本文总结了微通道反应器的特点、微通道反应器中常用的流体驱动技术和微通道中流体的混合技术.通过一系列在微流控芯片中进行的有机合成反应,包括液-液均相反应、催化反应、相转移反应和异常激烈的有机合成反应等,进一步说明了微通道反应器同时具有微量和连续流动的优点.微通道反应器的发展不但在合成路线的优化方面有重要意义,而且有助于相关化学工业过程的改进. 相似文献
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微流控芯片以其强大的微流体和微小物质控制能力成为研究单细胞、细胞群落乃至生物组织的重要手段。在本篇综述中,我们将以微流控芯片上细胞体外培养模型的建立为主,对近几年来重要的研究工作加以评述,全面地介绍微流控技术在细胞生命科学研究中应用的优势和未来发展方向,具体包括微流控芯片的细胞操控能力、细胞培养微环境的构建以及芯片联用检测手段,希望为从事这一领域研究工作的读者提供一些新的思路。 相似文献
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生殖是生物体最基本特征之一,是物种得以延续和进化的保证。近年来,微流控芯片系统得到了迅猛发展,技术也逐渐成熟,具有良好的应用前景。在生殖研究中,微流控技术具有以下优势:微管道的形状和尺寸可以灵活设计,从而更好地模拟生理环境;微流控芯片对样品的消耗量低;微流控技术具有很高的集成性。微流控技术已被应用到精子活力评价与筛选、精子的化学趋向性筛选、卵丘细胞去除、透明带移除、卵细胞定位与筛选、受精过程、早期胚胎培养以及生殖器官模拟等各个方面。该文着重介绍近几年基于微流控技术生殖研究的最新进展,并对其应用前景进行展望。 相似文献
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Microfibers, a type of long, thin, and flexible material, can be assembled into functional 3D structures by folding, binding, and weaving. As a novel spinning method, combining microfluidic technology and wet spinning, microfluidic spinning technology can precisely control the size, morphology, structure, and composition of the microfibers. Particularly, the process is mild and rapid, which is suitable for preparing microfibers using biocompatible materials and without affecting the viability of cells encapsulated. Furthermore, owing to the controllability of microfluidic spinning, microfibers with well-defined structures (such as hollow structures) will contribute to the exchange of nutrients or guide cell orientation. Thus, this method is often used to fabricate microfibers as cell scaffolds for cell encapsulation or adhesion and can be further applied to biomimetic fibrous tissues. In this review, the focus is on different fiber structures prepared by microfluidic spinning technology, including solid, hollow, and heterogeneous structures, generated from three essential elements: spinning platform, fiber composition, and solidification methods. Furthermore, the application of microfibers is described with different structures in tissue engineering, such as blood vessels, skeletal muscle, bone, nerves, and lung bronchi. Finally, the challenges and future development prospects of microfluidic spinning technology in tissue engineering applications are discussed. 相似文献
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Qin Tu Long Pang Yanrong Zhang Maoseng Yuan Jianchun Wang Dongen Wang Wenming Liu Jinyi Wang 《中国化学》2013,31(3):304-316
Microfluidic devices, as a new miniaturized platform stemming from the field of micro-electromechanical sys-tems, have been used in many disciplines. In the field of chemical reactions, microfluidic device-based microreac-tors have shown great promise in building new chemical technologies and processes with increased speed and reli- ability and reduced sample consumption and cost. This technology has also become a new and effective tool for precise, high-throughput, and automatic analysis of chemical synthesis processes. Compared with conventional chemical laboratory batch methodologies, microfluidic reactors have a number of features, such as high mixing ef- ficiency, short reaction time, high heat-transfer coefficient, small reactant volume, controllable residence time, and high surface-to-volume ratio, among others. Combined with recent advances in microfluidic devices for chemical reactions, this review aims to give an overview of the features and applications of microfluidic devices in the field of chemical synthesis. It also aims to stimulate the development of microfluidic device applications in the field of chemical reactions. 相似文献
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Lv Zhu Mengyao Wu Ruiyu Li Yunyan Zhao Yang Lu Ting Wang Leilei Du Li Wan 《Electrophoresis》2023,44(17-18):1377-1404
The problem of pesticide residue contamination has attracted widespread attention and poses a risk to human health. The current traditional pesticide residue detection methods have difficulty meeting rapid and diverse field screening requirements. Microfluidic technology integrates functions from sample preparation to detection, showing great potential for quick and accurate high-throughput detection of pesticide residues. This paper reviews the latest research progress on microfluidic technology for pesticide residue detection. First, the commonly used microfluidic materials are summarized, including silicon, glass, paper, polydimethylsiloxane, and polymethyl methacrylate. We evaluated their advantages and disadvantages in pesticide residue detection applications. Second, the current pesticide residue detection technology based on microfluidics and its application to real samples are summarized. Finally, we discuss this technology's present challenges and future research directions. This study is expected to provide a reference for the future development of microfluidic technology for pesticide residue detection. 相似文献
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Yan Song Xiao-Qing Yu Su Chen 《Journal of polymer science. Part A, Polymer chemistry》2024,62(3):447-462
Fiber-spinning chemistry (FSC) has emerged as a promising micro-reaction platform due to its high-specific surface area, efficient heat and mass transfer, and enhanced reaction rate. The FSC strategy employs spinning fibers as microreactors, lessening the emissions of volatile organic compounds (VOCs), and realizing the design of micro/nanoscale fibers and the synthesis of nanomaterials. In this review, we highlight the latest advancements in FSC in respect of preparation mechanisms and technical advantages. Various FSC strategies, including microfluidic spinning, electro-microfluidic spinning (EMS), and microfluidic blow spinning (MBS) are emphasized. In particular, the regulation of microfluidic chips in the FSC process is introduced. Additionally, the application of the FSC strategy is summarized in the synthesis of fluorescent nanomaterials, nonweaving for multidimensional fibers, and all-weather smart textiles. Finally, the advanced progress and future perspectives are discussed. Overall, this review will provide theoretical guidance for the design of well-defined micro/nanoscale fibers based on the FSC platforms. 相似文献
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《Electrophoresis》2017,38(7):953-976
Microfluidics has emerged following the quest for scale reduction inherent to micro‐ and nanotechnologies. By definition, microfluidics manipulates fluids in small channels with dimensions of tens to hundreds of micrometers. Recently, microfluidics has been greatly developed and its influence extends not only the domains of chemical synthesis, bioanalysis, and medical researches but also optics and information technology. In this review article, we will shortly discuss an enlightening analogy between electrons transport in electronics and fluids transport in microfluidic channels. This analogy helps to master transport and sorting. We will present some complex microfluidic devices showing that the analogy is going a long way off toward more complex components with impressive similarities between electronics and microfluidics. We will in particular explore the vast manifold of fluidic operations with passive and active fluidic components, respectively, as well as the associated mechanisms and corresponding applications. Finally, some relevant applications and an outlook will be cited and presented. 相似文献