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1.
IntroductionPodophyllotoxin (1)isawellknownnaturalproductendowedwithpotentantineoplasticactivity .1Thesynthe sisandpreparationofdifferenttypesofderivativesofthismoleculehavebeenattractingmuchinterestofbothorgan icchemistsandmedicinalchemists .2 Inthispaper … 相似文献
2.
HongMinMA ZhanZhuLIU ShiZhiCHEN XiaoTianLIANG 《中国化学快报》2004,15(7):759-761
A concise and efficient synthesis of the new compounds tetrahydroisoquino [2,1-c] [1,3]benzodiazepine 5 and 7 is reported. 相似文献
3.
Russian Journal of Organic Chemistry - New spiro heterocycles, spiro[benzo[h]chromene-4,3′-indoles] and spiro[benzo[f]chromene-1,3′-indoles], have been synthesized in 50–60% yield... 相似文献
4.
Hong Min MA Zhan Zhu LIU Shi Zhi CHEN Xiao Tian LIANGInstitute of Materia Medica Peking Union Medical College & Chinese Academy of MedicalSciences Beijing 《中国化学快报》2004,(7)
A concise and efficient synthesis of the new compounds tetrahydroisoquino [2,1-c] [1,3] benzodiazepine 5 and 7 is reported. 相似文献
5.
YANChao-guo GEYun 《高等学校化学研究》2005,21(2):232-235
Calix[4]resorcinarenes are cyclic tetramers in which four resorcinol units are linked via alkylmethylene bridges in the o-position to each resorcinic hydroxyl group. Their structures resemble that of p-butylcalix[n]arenes and render them of interest as host compounds in many contemporary fields of supramolecular chemistry. Therefore, 相似文献
6.
Synthesis of a 1,2,7,8-Tetraoxa-spiro[5.5]undecane 总被引:1,自引:0,他引:1
Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy linkage. The hydroperoxyl groups were then bonded at the OH ends via Hg(II)-induced electrophilic additions to the C-C double bonds, giving a novel sprio structure with one peroxy bond in each of the two six-membered rings. The ester functionalities in the side chains also make it possible to conduct further structural modifications. 相似文献
7.
ChaoGuoYAN YunGE 《中国化学快报》2004,15(9):1019-1021
Three different synthetic routes were developed to introduce carbamoyloxy functional groups at the upper periphery of two calix[4]resorcinarenes. By treating activated esters 2a-b with excess corresponding amine such as 3-(dimethylamino)propylamine 3, ct-phenethylamine 4 and triethylenetetramine 5, six amide derivatives 6a-8b were obtained in high yield (Route 1). The pyridine-linked amide derivatives 9a-b were prepared by using acid chloride intermediate (Route 2).The amide derivatives 10a-b were obtained in moderate yields by direct alkylation of phenolic hydroxyl groups of la-b with N,N-dipropylchloroacetoamide in the presence of K2CO3/KI in acetone (Route 3). 相似文献
8.
Chuan Ming JIN Guo Yuan LU* Xiao Zeng YOU Department of Chemistry State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 《中国化学快报》2001,(11)
Calixarenes are a versatile class of macrocyclic compounds which have attracted extensive interest due to their ability to form host-guest complexes and act as enzyme mimic, especially when appropriately functionalized1. Introduction of azo group to calixarenes can make the later to be easily detected in the process of molecular recognition, azo groups have been introduced into calixarenes by the diazo-coupling reaction of calix[4]arene with BF4- or chloride salt of substituted benzene diazon… 相似文献
9.
Tsizorik Nazar M. Hrynyshyn Yevhenii V. Bol’but Andriy V. Vovk Mykhailo V. 《Chemistry of Heterocyclic Compounds》2018,54(11):1075-1078
Chemistry of Heterocyclic Compounds - 4-Chloropyrazolo[1,5-a]pyrazines react with ethyl isocyanoacetate to form ethyl imidazo[1,5-a]pyrazolo[5,1-c]pyrazine-1-carboxylates, hydrolysis of which... 相似文献
10.
Sergey I. Kovalenko Oksana V. Krivoshey Svetlana V. Shishkina Oleg V. Shishkin 《合成通讯》2013,43(21):3719-3727
4‐Hydrazinoquinazoline was found to form new 2‐(3,4‐dihydro‐3oxo‐2H‐[1,2,4]triazino[4,3‐c]quinazolin‐4‐yl)acetic acid with maleic anhydride in on‐step sequence. Proposed heterocyclization includes, probably, acylation reaction followed by intramolecular uncleophilic addition. 相似文献
11.
Homochiral cis,cis-; cis,trans- and trans,trans-spiro[4.4]nonane-1,6-diols were prepared via diastereoselective reduction of enantiomerically pure spiro[4.4]nonane-1,6-dione (1) with the corresponding reducing agents: lithium n-butyldiisobutylaluminium hydride for cis,cis-diol (2) with 88% yield; BH3·THF for cis, trans-diol (3) with 91% yield; LiAlH4 for trans,trans-diol (4) with 15% yield. 相似文献
12.
Dr. Jingyun Tan Dr. Xiushang Xu Jun Liu Dr. Serhii Vasylevskyi Dr. Zesen Lin Prof. Ryota Kabe Prof. Yingping Zou Prof. Klaus Müllen Prof. Akimitsu Narita Prof. Yunbin Hu 《Angewandte Chemie (International ed. in English)》2023,62(18):e202218494
Double helicenes are appealing chiral frameworks. Their π-extension is desirable to achieve (chir)optical response in the visible and near-infrared (NIR) region, but access to higher double [n]helicenes (n≥8) has remained challenging. Herein, we report an unprecedented π-extended double [9]helicene ( D9H ), unambiguously revealing its structure by single-crystal X-ray diffraction. D9H shows remarkable NIR emission from 750 to 1100 nm with a high photoluminescence quantum yield of 18 %. In addition, optically pure D9H exhibits panchromatic circular dichroism with a notable dissymmetry factor (gCD) of 0.019 at 590 nm, which is among the highest in the visible region for reported helicenes. 相似文献
13.
Cheng Gang ZHANG Bo Gang LI Xiang Ge ZHOU Guo Lin ZHANG* Chengdu Institute of Biology Chinese Academy of Sciences Chengdu Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 《中国化学快报》2004,15(3):269-272
Phenanthroindolizidine and phenanthroquinolizidine are closely related groups of alkaloids. Since the first isolation of tylophorine 1 in 1935, these natural products have attracted much attention because of their interesting biological activities such as antitumor activity1-3. The obvious problems such as toxicity to nerve system, instability and uneconomical synthetical pathways restrict its application. Kozma reported that C-9, C-14 of tylophorine 1 and C-9, C-15 of cryptopleurine 2 we… 相似文献
14.
A New Efficient Synthesis of p-Nitrocalix[4]arene 总被引:1,自引:0,他引:1
YongLI JiaSongWANG QiWANG DeShanLI 《中国化学快报》2004,15(4):400-403
A new efficient synthesis of p-nitrocalix[4]arene from calix[4]arene by using nitrogen dioxide is described.The compound is an useful intermediates for the introduction of other functional groups to obtain N containing substituted calix[4]arene.The reaction mechanism is briefly discussed. 相似文献
15.
p-tert-Butylcalix[6]-1,4-2,5-biscrown-4 is a typical member of the family of calix[6]crowns. In the literature, the compound was synthesized from calix[6]arene by two steps and the overall yield based on calix[6]arene was 24%.Herein we wish to report a one-pot method to do this work. By this method the yield was up to 48% and the reaction time was greatly reduced. 相似文献
16.
《中国化学快报》1997,(5)
Dendrimer5arethree-dimensional,highorderedoligomericandPOlymericcomPOundS,whicharemo1ecular-1evelcontrolofsize,shapes,surfacechentistry,toPOlogyandflexibility.'.'Calixarenesarecyclicoligomers,whichhavebeenextensive1ystudiedinordertoobtalnnewhostsbyappropriatefiJnctionalizationoftheparentmolecule.3,#Besides,calixarenesareattractivecandidatesfOrpolponctionalcoresindendriticmolecules,esPeciallybytheconvergentgroWthaPProach.'ltisinterestingthatthemoleculeofcombinationofcalixarenewithdendritic… 相似文献
17.
Yagodkina-Yakovenko M. S. Bol’but A. V. Vovk M. V. 《Russian Journal of Organic Chemistry》2018,54(10):1569-1572
Russian Journal of Organic Chemistry - Methyl 2-(bromomethyl)thiophene-3-carboxylates reacted with substituted 2-hydroxybenzonitriles to give methyl... 相似文献
18.
Nilam C. Dige 《合成通讯》2013,43(21):2498-2510
An efficient, four-component reaction of isatin, 1,3-indanedione, ethyl acetoacetate, and ammonium acetate in ethanol/water (9:1) system furnished spiro[4H-indeno[1,2-b]pyridine-4,3′-[3H]indoles] at room temperature. Merits of the method are mild reaction conditions, simple workup procedure, and ambient temperature. The synthesized compounds exhibit excellent fluorescence properties. 相似文献
19.
p-Perfluoroalkylealix[4]arenes were prepared readily from the reaction of calix-[4]arene with perfluoroalkyl iodides in the presence of sodium dithionite or sodium hydroxy-methanesulfinate under mild conditions,These fluorine-containing calixarenes showed bettersolubilities in common organic solvents as compared to their nonperfluoroalkylation analogand formed inclusion complexes with many neutral molecules as well as fluorocarbons. 相似文献
20.
Synthesis of Schiff Base Calix [4] arene Crowns 总被引:2,自引:0,他引:2
This letter reports the synthesis of Schiff base calix [4] arene crowns containing m-xylylene phenol subunit, in which calix [4] arene Schiff base crowns 2a,2b and 2c were formed by 1:1 condensation of calix [4] arene diamine 1 with dialdehydes (2,6-diformyl-4-chlorophenol 3a,2,6-diformyl-4-methylphenol 3b,2,6-diformyl-4-tert-butylphenol 3c)under high dilute condition in refluxing anhydrous ethanol in 65-70% yield. 相似文献