校企合作下应用化工技术专业订单式人才培养模式的探索

立足于学校应用化工技术专业校企合作协议,考虑到社会及企业的要求及高职学生的特点,讨论制定了应用化工技术专业订单式人才培养方案,经过不断修改和完善,逐步取代了原来的学科课程体系,初步形成了新的人才培养方案,具体包括专业设置及培养目标定位、课程体系与教学内容的改革、人才培养方案的实施与保障及考核与评价方面的创新。     

高职化工创新型人才培养体系的构建与实践

按照高职教学规律,说明了高职创新型人才培养的必要性,并进行了高职化工专业创新型人才体系的构建实践,探讨了化工创新型人才培养经验。     

高等职业教育人才培养策略研究——评《高等职业教育人才培养模式构建概论》

由张向东、卢红学著的《高等职业教育人才培养模式构建概论》(武汉大学出版社2013年出版),基于高等职业教育培养技能型专门人才的重要使命,高等职业教育改革与发展的趋势,高等职业教育理论研究的不足,通过深入分析当前高职教育人才培养的现状,探讨了高等职业教育人才培养的模式及其构建。     

地方高校应用型人才培养模式改革与创新的探索与实践

探索、深化人才培养模式成为地方高校日益关注和重视的问题。以重庆第二师范学院应用化学专业（化工制药与药物分析检测方向）为例,分别从人才培养方案的制定、教学模式的探索、课程改革的实施和条件保障等4个方面加以分析和讨论,阐述地方本科院校在推进应用型人才培养方面的经验和途径。结果表明,针对地方应用型本科高校的功能定位,人才培养模式应该更加注重与当地企业的密切联系,努力满足行业对于化学制药与分析检测人才的要求。     

产教融合下高职“三三结合式”人才培养模式*——以药品生产技术专业为例

针对高职产教融合存在的问题,构建了“三三结合式”人才培养模式,即通过“企业指导、行业引导、学校督导”三结合,改革人才培养模式;通过“核心课程、核心问题、核心能力”三结合,深化“教师、教材、教法、教学评价”四教改革;通过“基础实验、专业实验,实习实训”三结合,优化实践教学体系。该模式的构建与实施能提升学生的职业素养,提高毕业生的就业质量,打造出优秀的双师型教师团队。     

学科深度交叉促进分析化学高层次人才培养研究与实践

为了适应高等教育改革和创新型人才培养的新要求,改变人才培养模式尤为重要。以培养创新型人才为目标,学科交叉为驱动,多院系合作为支撑,从课程体系设置、培养目标等方面入手,探索了学科交叉在分析化学研究生培养中的作用,并通过联合培养制度、学科交叉论坛等方式进行了实践。     

应用化学专业“3+1”人才培养模式的探索与实践

面对新形势下社会对应用化学专业人才的需求,教育工作者应该更新观念,采取更加灵活的改革措施,以适应经济发展的需要。进行了应用化学专业3年专业理论教学和1年顶岗实习即“3+1”人才培养模式的探索,并且对该模式下人才培养目标的确定、课程体系的优化、实验和科研能力的培养以及实习计划的制定,都进行了具体的阐述,希望能为高等教育教学改革积累经验。     

高职“石油化工专业群”复合型技术技能人才“五跨”培养模式的探索与实践

为培养一批符合社会需求、企业欢迎的“宽基础、多技能、高素质”的复合型技术技能人才,借鉴国内外先进职教经验,以高职石油化工专业群为试点,创建了跨专业复合人才培养体系。通过采取“理实一体化”教学改革,建立现代学徒制试点,推广校企“双主体”协同育人方案,开展跨学院、跨国境交流,打造复合型师资队伍等策略,探索并实践了复合型技术技能人才“跨专业、跨理实、跨校企、跨学院、跨国境”的“五跨”培养模式。     

物理化学教学模式的探索与实践

在当今高等教育创新人才培养要求下,结合国内外教育先进技术方法,通过物理化学教学实践,探索了讲授课堂、翻转课堂、对分课堂等3种教学模式,教学实效性结果表明,开放式的教学更利于提高教学质量,对分课堂教学模式更适合于我校学生学习物理化学。     

基于应用型人才培养理念下的课程思政教育建设

应用技术型大学是以培养应用型人才为主的大学,但若只重视应用型培养而忽视思政教育,已经不符合时代的要求。"课程思政"是高校人才培养的新理念,专业课程教师需在应用型人才培养的理念下,把思政教育融入专业教学中,将"应用型人才培养"与"课程思政教育建设"有机融合,实现应用型人才培养模式下课程思政教育建设。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Microwave-assisted copper-catalyzed stereoselective ring expansion of three-membered heterocycles with α-diazo-β-dicarbonyl compounds

Microwave-assisted copper-catalyzed ring expansions of three-membered heterocycles with α-diazo-β-dicarbonyl compounds were investigated. Thiiranes generated 3-acyl-5,6-dihydro-1,4-oxathiines in the presence of copper sulfate and trans-3-acyl-5,6-dihydro-1,4-oxathiines as stereospecific products for 1,2-disubstituted cis-thiiranes through an intramolecular S_N2 process. Oxiranes gave rise to 2-acyl-5,6-dihydro-1,4-dioxines under the catalysis of copper hexafluoroacetylacetonate and cis-3-acyl-5,6-dihydro-1,4-dioxines as stereospecific products for 1,2-disubstituted cis-oxiranes via an intimate ion-pair mechanism. The current method provides a direct and simple strategy in efficient preparation of 3-acyl-5,6-dihydro-1,4-oxathiines and 2-acyl-5,6-dihydro-1,4-dioxines, important agents in medicinal and agricultural chemistry, from readily available thiiranes and oxiranes, respectively.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.