共查询到20条相似文献,搜索用时 140 毫秒
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Breslow(Columbia大学)在Houston举行的美国化学会上接受物理有机化学的James Flack Norris奖金时提出了他在物理有机化学上的哲学观点,以下是谈话的摘录。物理有机化学的领域已广为开拓,在许多方面已吸引了很多青年学生投身于中,尽管他们对经典的合成方向兴趣依然不衰——经典的合成方向对许多有机化学的学生确实有着很大的吸引力。虽然道理并不完全清楚,但值得注意的是,物理有机化学家已承担了合成非天然产物的任务。换句话说,就是合成一些新的分子,通过 相似文献
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有机化学象其他科学一样在解放后的十年中由于党的正确领导,获得了空前的发展。在解放前我国的有机化学及其工业非常薄弱,过去的有机化学研究工作主要是同卫生事业(如中药,生物硷及激素等方面的研究)及轻工业(如染料化学,纤维素化学等方面的研究)的需要相结合的。最主要的方向是复杂的天然化合物及其类似物的合成。因而在有机理论方面以立体化学最有成就。在解放后的十年中,由于党的重视与支持,我国有机化学的研究及其工业不仅飞跃前进,并 相似文献
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环糊精是一类由6~8个D-型葡萄糖连接而成的环聚多糖分子,目前已广泛应用于化学和生物学的许多领域.综述了一些生物活性的环糊精超分子组装体,如环糊精假聚轮烷、环糊精/金纳米粒子组装体、环糊精/富勒烯组装体、环糊精/碳纳米管组装体等的构筑及其与核酸的相互作用,如对核酸的切割、凝聚、传递作用和对核酸酶的抑制作用等方面的研究进展. 相似文献
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Zai-Hui DU Xiang-Yang LI Jing-Jing TIAN Yang-Zi Zhang Hong-Tao TIAN Wen-Tao XU 《分析化学》2018,46(7):995-1004
Functional nucleic acids are natural or artificial nucleic acid sequences with specific functions and special structures. A part of metal ions are essential trace elements of human health, but excessive metal ions will be harmful to human health. The functional nucleic acids are widely used for detection of metal ions because of its advantages such as easy modification, low price, high stability and strong specificity. This paper detailed the interaction between functional nucleic acids and metal ions, mainly including cutting type, link type, metal ion-mediated base pairing, click chemistry type, conformational change type, and other types. The biosensors based on the combination of functional nucleic acid with different signal output were then introduced. Finally, the research significance and existing problems of functional nucleic acid for metal ion detection were discussed. The future development trends and applications of functional nucleic acid biosensor were prospected. 相似文献
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Functional nucleic acids(FNAs) refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids, which have been widely applied in screening, sensing and imaging fields. However, the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability, biocompatibility, biodistribution and immunity of natural nucleic acids(DNA/RNA). Xeno nucleic acids(XNAs) are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties, including improved biological stability, increased binding affinity, reduced immune responses, and enhanced cell penetration or tissue specificity. In the last two decades, scientists have made great progress in the research of functional xeno nucleic acids, which makes it an emerging attractive biomedical application material. In this review, we summarized the design of functional xeno nucleic acids and their applications in the biomedical field. 相似文献
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Daniela Perrone Elena Marchesi Lorenzo Preti Maria Luisa Navacchia 《Molecules (Basel, Switzerland)》2021,26(11)
The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules. Many nucleoside analogs are known for their marked impact in cancer therapy and for the treatment of virus diseases and new targeted oligonucleotides have been developed for different purposes. The click chemistry allowing the tolerated union between units with a wide diversity of functional groups represents a robust means of designing new hybrid compounds with an extraordinary diversity of applications. This review provides an overview of the most recent works related to the use of click chemistry methodology in the field of nucleosides, nucleotides and nucleic acids for pharmacological applications. 相似文献
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A. Jancik Prochazkova S. Gaidies C. Yumusak O. Brüggemann M. Weiter N.S. Sariciftci M.C. Scharber K. Čépe R. Zbořil J. Krajcovic Y. Salinas A. Kovalenko 《Materials Today Chemistry》2020
Nanostructural hybrid organic-inorganic metal halide perovskites offer a wide range of potential applications including photovoltaics, solar cells, and light emitting diodes. Up to now the surface stabilizing ligands were used solely to obtain the optimal properties of nanoparticles in terms of dimensionality and stability, however their possible additional functionality was rarely considered. In the present work, hybrid lead bromide perovskite nanoparticles (PNP) were prepared using a unique approach where a peptide nucleic acid is used as a surface ligand. Methylammonium lead bromide perovskite colloidal nanoparticles stabilized by thymine-based peptide nucleic acid monomer (PNA-M) and relevant trimer (PNA-T) were prepared exhibiting the size below 10 nm. Perovskite structure and crystallinity were verified by X-ray powder diffraction spectroscopy and high resolution transmission electron microscopy. PNP-PNA-M and PNP-PNA-T colloidal dispersions in chloroform and toluene possessed green-blue fluorescence, while Fourier-transform infrared spectroscopy (FT-IR) and quantum chemical calculations showed that the PNA coordinates to the PNP surface through the primary amine group. Additionally, the sensing ability of the PNA ligand for adenine nucleic acid was demonstrated by photoluminescence quenching via charge transfer. Furthermore, PNP thin films were effectively produced by the centrifugal casting. We envision that combining the unique, tailored structure of peptide nucleic acids and the prospective optical features of lead halide perovskite nanoparticles could expand the field of applications of such hybrids exploiting analogous ligand chemistry. 相似文献
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LIU Shaopu HU Xiaoli LIU Zhongfang LI Ming & WANG Fen School of Chemistry Chemical Engineering Southwest China Normal University Chongqing China 《中国科学B辑(英文版)》2005,48(6):591-599
The interaction between nucleic acids and medicine molecule is one of the important research fields of nucleic acids, which is very valuable for investigating the interactive mechanisms of anti-cancer and anti-virus medicine, screening medicine in vitro, … 相似文献
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Chi Zhang Ekaterina V. Vinogradova Alexander M. Spokoyny Stephen L. Buchwald Bradley L. Pentelute 《Angewandte Chemie (International ed. in English)》2019,58(15):4810-4839
Bioconjugation chemistry has been used to prepare modified biomolecules with functions beyond what nature intended. Central to these techniques is the development of highly efficient and selective bioconjugation reactions that operate under mild, biomolecule compatible conditions. Methods that form a nucleophile–sp2 carbon bond show promise for creating bioconjugates with new modifications, sometimes resulting in molecules with unparalleled functions. Here we outline and review sulfur, nitrogen, selenium, oxygen, and carbon arylative bioconjugation strategies and their applications to modify peptides, proteins, sugars, and nucleic acids 相似文献
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Peptide nucleic acids (PNAs) have been used to encode a combinatorial library whereby each compound is labeled with a PNA tag which reflects its synthetic history and localizes the compound upon hybridization to an oligonucleotide array. We report herein the full synthetic details for a 4000 member PNA-encoded library targeted towards cysteine protease. 相似文献
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Quantum chemical calculations are reported on the deprotonation and protonation of the amino groups of the nucleic acid bases adenine, guanine and cytosine, in an attempt to compare the relative reactivities of these groups. In the light of renewed interest in the amino groups as reactive sites for certain carcinogenic and carcinostatic agents, we discuss the possible significance of our results for the interpretation of these molecular interactions. 相似文献