共查询到17条相似文献,搜索用时 140 毫秒
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研究了以2-羟基-4-甲氧基苯甲醛和2-氨基-6-甲基吡啶为原料合成新型席夫碱化合物5-甲氧基-2-[(E)-(6-甲基吡啶-2-亚氨基)甲基]苯酚的方法。当2-羟基-4-甲氧基苯甲醛与2-氨基-6-甲基吡啶摩尔比为1∶1.6,反应时间为6 h,反应温度为75℃时,反应产率最高。采用元素分析、UV-Vis、IR、1H NMR、X-射线单晶衍射等方法进行结构表征。该化合物为单斜晶系,空间群P21/c,a=1.1886(3)nm,b=0.65948(16)nm,c=1.6897(4)nm,β=108.505(3)°,V=1.2560(5)nm3,Dc=1.281 g·cm-3,Z=4,F(000)=512,μ=0.087 mm-1,R1=0.0477,wR2=0.1342。通过π···π堆积和分子内氢键O2-H2···N1、C8-H8A···N2形成较稳定的晶体结构,并具有蓝色荧光。 相似文献
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含有 1 ,2 ,4 三嗪结构的化合物具有广泛的生理活性。我们曾用α 乙酰基硫代甲酰芳胺为原料 ,合成了一系列三嗪类和其它杂环化合物 ,其中1 ,2 ,4 三嗪类有 4,6 二取代 5 硫酮 1 ,2 ,4三嗪 3 酮[1 ,2 ] ,3 氨基 5 取代苯氨基 6 苯基 1 ,2 ,4 三嗪[3] 等化合物。本文以α 乙酰基硫代甲酰芳胺为原料 ,进一步合成 5 取代苯氨基 6 甲基 1 ,2 ,4 三嗪 3 硫酮。当乙酰基硫代甲酰芳胺 1 (a g)与氨基硫脲 2反应时 ,首先生成缩氨基硫脲 3(a g) ,然后环化得到 5 取代苯氨基 6 甲基 1 ,2 ,4 三嗪 3硫酮 4(a g) ,合成中发现 ,4(a g)可… 相似文献
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我们曾对4-氨基-5-亚硝基尿嘧啶系列物在高超电势下的还原机理做过一些研究[1,2]。在低超电势下的还原机理尚未见报道。本工作用伏安法及恒电流阶跃法探讨了酸性介质中,3-甲基-4-氨基-5-亚硝基尿嘧啶(简写为3-MU)在低超电势范围内的还原历程。 相似文献
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ZhiLiZHANG PengHAN XiaoYanMA JieLIU XiaoWeiWANG JunYiLIU 《中国化学快报》2005,16(3):287-289
6-Methyluracil and 5-nitro-6-methyluracil react with variable molar quantities of benzoyl chloride in acetonitrile-pyridine at room temperature to give I-N, 3-N-dibenzoyl-6-methyluracil 3b and l-N-benzoyl-5-nitro-6-methyluracil 4b. The reactive rates of debenzoylation of 3b and 4b were investigated. 相似文献
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Yu. I. Murinov T. R. Nugumanov S. P. Ivanov M. E. Kletskii I. F. Kamaletdinov V. I. Minkin 《Chemistry of Heterocyclic Compounds》2009,45(4):461-467
It has been discovered experimentally that 5,5,6-trihydroxy-6-methylpyrimidine-2,4-dione is formed on oxidizing 5-hydroxy-6-methyluracil
with molecular oxygen in aqueous medium in the presence of copper(II) chloride. Ab initio and DFT calculations on the 6-31G*
basis, both in the gas phase and allowing for solvent, showed that the process proceeds with the direct participation of an
activated oxygen molecule on the complex CuCl2·(5-hydroxy-6-methyluracil)2.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 586-593, April, 2009. 相似文献
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1,3-Bis(4-bromobutyl)-6-methyluracil reacts with diethyl 2-(dimethylamino)ethylphosphonate to form a bisquaternary ammonium
salt, whereas the reaction of 1,3-bis-(6-bromohexyl)-6-methyluracil with diethyl 2-(diethylamino)ethyl phosphate gives 1,3-bis-[(6-diethoxyphosphoryloxy)hexyl]-6-methyluracil
and 1,1,4,4-tetraethylpiperazinium dibromide.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1130–1132, June, 2000. 相似文献
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Stanislav A. Grabovskiy Yuri I. MurinovNatalia N. Kabal’nova 《Tetrahedron letters》2012,53(45):6025-6028
Dehydration of 5,6-dihydro-5,6-dihydroxy-6-methyl- and 5,6-dihydro-5,6-dihydroxy-1,3,6-trimethyl-uracil in 0.4 M aqueous sulfuric acid gives 5-hydroxy-6-methyl- and 5-hydroxy-1,3,6-trimethyluracil in quantitative yields. Two possible mechanisms have been examined using the mPW1k/6-311+G(2df,2pd)//mPW1k/6-31+G(d,p) method for the transformation of methylated and non-methylated 5,6-dihydro-5,6-dihydroxy-6-methyluracils into the corresponding 5-hydroxy-6-methyluracils. The first is a hydride C5-C6 shift occurring in concert with the loss of a water molecule and formation of the corresponding protonated 5,6-dihydro-5-oxo-6-methyluracils. The second is an acid-catalyzed dehydration reaction to yield 5-hydroxy-6-methyluracils. The calculations demonstrated that the second pathway was energetically most favorable. 相似文献
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Manuel A.V. Ribeiro da Silva Luísa M.P.F. Amaral Piotr Szterner 《The Journal of chemical thermodynamics》2011,43(12):1924-1927
The standard (p° = 0.1 MPa) molar enthalpies of formation, in the crystalline phase, at T = 298.15 K, for 5-methyluracil, 6-methyluracil, and 5-nitrouracil were derived from the values of the standard massic energies of combustion measured by static bomb combustion calorimetry. The results obtained together with literature values of the enthalpies of sublimation yielded the standard molar enthalpies of formation, in gaseous phase, at T = 298.15 K. These values are discussed in the terms of structural enthalpic increments. 相似文献
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V. R. Khairullina S. A. Kirlan A. Ya. Gerchikov L. A. Tyurina G. G. Garifullina Yu. B. Monakov E. A. Kantor A. V. Kirlan 《Russian Chemical Bulletin》2006,55(8):1322-1327
A mathematical model for prediction of antioxidant activity (AOA) with a recognition level of ∼90% was developed using the
SARD-21 computer system. Based on this model, structural modification of ionol and 5-hydroxy-6-methyluracil was carried out.
A set including 32 potential antioxidants was generated. The interval levels of toxicity were theoretically predicted and
the effect of structural fragments on the toxic properties of the most efficient potential antioxidants was analyzed. Structural
attributes characteristic of highly efficient, low-toxicity antioxidants were revealed for the first time. Based on complex
analyses of the AOA and toxicity, thirteen structures of potentially efficient low-toxicity antioxidants were proposed.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1274–1279, August, 2006. 相似文献
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The reduction of 1-methyl-, 3-methyl- and 1,3-dimethyl-5-nitrouracil (Ia-c) to the corresponding 5-aminouracils (IIa-c) is described. Diazotization of 5-amino-1-methyluracil (IIa) and 5-amino-1,3-dimethyluracil (IIc) gave 5-diazouracils which were characterized as thermally stable C6 covalent hydrates (III and XIII). Diazotization of 5-amino-3-methyluracil (IIb) gave anhydro 5-diazo-3-methyluracil (X) which underwent covalent methanolation and thermally reversible covalent hydration. Treatment of III and XIII with hot methanol resulted in solvent exchange of the C6 hydroxyl groups by a mechanism which may involve initial formation of diazoethers. Treatment of the methanolates (IV, XI and XIV) with dimethylamine resulted in coupling at the diazo group with a concomitant expulsion of the C6 methoxyl groups to give 5-(3,3-dimethyl-1-triazeno)uracils (XVa-c). 相似文献