成像深度对光声层析成像的影响

为了研究不同成像深度对光声层析成像质量的影响,利用多元线性阵列探测器在有限方位进行探测成像。由仿真和实验结果表明,吸收体离探测器越近,其成像效果较好,当多元线性阵列探测器的尺寸与成像深度比小于1时,重建图像畸变明显。在这种情况下,采用旋转扫描探测,其成像效果明显提高。该研究结果对光声层析成像扫描轨迹的设计、成像效果评估具有较好的参考价值。     

Pulse decomposition-based analysis of PAT/TAT error caused by negative lobes in limited-view conditions

Pulse decomposition has been proven to be efficient to analyze complicated signals and it is introduced into the photo-acoustic and thermo-acoustic tomography to eliminate reconstruction distortions caused by negative lobes.During image reconstruction,negative lobes bring errors in the estimation of acoustic pulse amplitude,which is closely related to the distribution of absorption coefficient.The negative lobe error degrades imaging quality seriously in limited-view conditions because it cannot be offset so well as in full-view conditions.Therefore,a pulse decomposition formula is provided with detailed deduction to eliminate the negative lobe error and is incorporated into the popular delay-and-sum method for better reconstructing the image without additional complicated computation.Numerical experiments show that the pulse decomposition improves the image quality obviously in the limited-view conditions,such as separating adjacent absorbers,discovering a small absorber despite disturbance from a big absorber nearby,etc.     

滑动焦点光声显微成像方法

在高分辨光声显微成像系统中,只有在有限焦深范围内的吸收体可以获得高分辨率高信噪比的成像,而实际的生物组织往往具有不规则的轮廓,导致成像结果分辨率和信噪比不均匀。提出了一种基于稀疏扫描轮廓的滑动焦点光声显微成像方法,首先在固定的焦点上稀疏扫描轮廓,人工选择轮廓点获取轮廓的稀疏矩阵,然后通过双调和(Biharmonic)插值获取完整的轮廓矩阵,并将轮廓矩阵转化为焦点位置移动矩阵,最后进行二次扫描,根据焦点位置移动矩阵在每次扫描之前调整焦点位置,使得在整个扫描过程中,样品始终处于焦深的范围,从而获得分辨率和信噪比均匀的光声显微图像。通过模型实验和在体皮下血管成像、颅下血管成像,证明了该方法可以有效地提高光声成像的质量。     

Effects of size and arrangement of virtual transducer on photoacoustic tomography

In this paper, we investigate the effects of the relative size and arrangement of a virtual transducer on the image quality in limited-view photoacoustic tomography. A virtual transducer refers to the acoustic scatterers used to reflect photoacoustic waves and improve the images reconstructed from incomplete PA signal. Size and spatial arrangement determine the performance of the virtual transducer. In this study, the scatterers utilized as virtual transducers are arranged in different manners, such as on a straight line or on an arc line. We find that virtual transducers with a big distributing angle can provide more significant image improvement than with a small distributing angle, which is similar to the true transducers. We also change the size of virtual transducer and study its influence on image quality. It is found that the bigger scatterers provide better images than the smaller ones. Especially, when the size of scatterers is reduced to the wavelength of photoacoustic wave, the image quality observably decreases, owing to the strong diffraction effect. Thus, it is suggested that the size of the acoustical scatterers should be much larger than the photoacoustic wavelength. The simulations are conducted, and the results could be helpful for the application and further study of virtual transducer theory in limited-view photoacoustic tomography.     

Evaluation of imaging protocol for ECT based on CS image reconstruction algorithm

Single-photon emission computerized tomography and positron emission tomography are essential medical imaging tools, for which the sampling angle number and scan time should be carefully chosen to give a good compromise between image quality and radiopharmaceutical dose. In this study, the image quality of different acquisition protocols was evaluated via varied angle number and count number per angle with Monte Carlo simulation data. It was shown that, when similar imaging counts were used, the factor of acquisition counts was more important than that of the sampling number in emission computerized tomography. To further reduce the activity requirement and the scan duration, an iterative image reconstruction algorithm for limited-view and low-dose tomography based on compressed sensing theory has been developed. The total variation regulation was added to the reconstruction process to improve the signal to noise Ratio and reduce artifacts caused by the limited angle sampling. Maximization of the maximum likelihood of the estimated image and the measured data and minimization of the total variation of the image are alternatively implemented. By using this advanced algorithm, the reconstruction process is able to achieve image quality matching or exceed that of normal scans with only half of the injection radiopharmaceutical dose.     

Long-range three-dimensional active imaging with superresolution depth mapping

We present a technique to overcome the depth resolution limitation for 3D active imaging. Applying microsecond laser pulses and sensor gate width, a scene of several hundred meters is illuminated and recorded in a single image. The trapezoid-shaped range intensity profile is analyzed to obtain both the reflectivity and the depth of scene. We demonstrate a 3D scene reconstruction in a depth of 650 to 1550 m from only three images with an accuracy of <30 m. This depth accuracy is 10 times better than estimated from the classical resolution limit obtained for depth scanning active imaging with a similar number of images. Therefore, this technique enables superresolution depth mapping with a reduction of image data processing.     

Saturable absorber using single wall carbon nanotube-poly (vinylalcohol) deposited by the vertical evaporation technique

We employed a vertical evaporation technique to fabricate saturable absorbers by embedding single wall carbon nanotubes (SWCNT) in polymer (vinylalcohol). Two fast recovery time constants, 250 fs and 1.13 ps, respectively, were measured for the absorbers using a transient absorption experimental setup. The saturation intensity of the absorber was found to be 300-400 μJ/cm² at 1060 nm, and a modulation depth as high as 3.5% was achieved.     

改进的同步迭代算法在光声血管成像中的应用

光声成像结合了光学成像和声学成像的优点，是一种高分辨率，高对比度的无损伤医学成像技术.一种改进的同步迭代算法应用于光声图像重建.仿真和模拟结果表明，与传统的代数迭代算法相比，在90°，135°，180°的有限场光声成像中，此算法对测量误差的校正和迭代次数的收敛上具有较大的优势，图像重建的速度和成像质量都有了明显的提高.实验中，一种圆形扫描结构的光声成像装置，用于180°的有限场扫描，利用改进的同步迭代算法，重建出了高对比度和高分辨率（60μm）的鸡胚胎光声血管图像.实验证明，这种算法的应用，大幅度减少了数据采集时间，为光声成像技术运用于实时监测血流灌注和肿瘤光动力治疗的血管损伤效应提供了潜在的应用价值. 关键词： 光声成像 有限角度 代数迭代算法 光声血管成像     

Low power phase conjugation in thin films of saturable absorbers

Organic dyes with high triplet yield are used as saturable absorbers with very low saturation intensity. Phase conjugation is performed in a thin film by a cw laser. The theory of degenerate four wave mixing in saturable absorbers is verified and imaging capabilities are demonstrated.     

复合扫描全息术及透过强散射介质三维成像研究

应用菲涅耳波带片光学扫描全息术原理，研究强散射介质中吸收体的三维成像.针对由成像物体强散射背景产生的背景噪音，提出复合扫描全息术成像方法.实验中应用这一方法，对嵌埋在浓度为1%，深度为1.7 cm的脂肪乳剂中的吸收体成像，得到了信噪比和对比度较好的再现像.在此基础上，对复合扫描全息成像系统的信噪比，对比度及分辨率等性能进行了深入的理论分析和实验测试.研究表明，与单一模式相比，复合扫描全息术在信噪比和对比度方面有较大改善，但分辨率还需进一步提高.     

有限方位扫描的光声断层成像分辨率研究

通过有限元仿真实验,定量地研究了有限方位扫描对反投影光声断层成像分辨率的影响,并且给出了有限方位扫描角与分辨率之间关系的经验公式.本文的研究结果对光声成像扫描轨迹设计、成像效果评估等具有参考价值. 关键词： 光声成像 有限方位扫描 分辨率 断层成像     

菲涅耳波带板扫描全息术透过高散射介质成像

将菲涅耳波带板扫描全息术用于高散射介质成像技术中。对于编码函数非负给物体的再现像带来的背景噪音．提出采用构造复合全息图的方法来消除。在实验中运用该方法得到了信噪比和衬比度较好的物体的再现像。计算并测试了系统的点扩展函数,实验结果与理论计算结果相吻合．其结果都接近于二维的δ函数。用菲涅耳波带板扫描全息成像系统进行了成像实验．得到了嵌埋在浓度为1％、深度为1．7cm的脂肪乳剂中的吸收体清晰的再现像,吸收体为直径0．4mm的金属丝和内径为6．0mm的金属环,另外．也得到了直径为2．5mm的黑塑料球的再现像。     

基于代数重建算法的有限角度扫描的光声成像

由于滤波反投影重建算法要求对成像区域进行全方位扫描以获取完全投影数据,它需要较长时间采集大量数据,使其在医学上的应用受到限制。研究了在有限角度下采用代数重建算法进行光声成像的方法,实验用的光源为YAG激光器,波长为1064nm,重复频率20Hz,脉宽为6ns,探测器为针状的磺化聚二氟乙烯(PVDF)膜水听器,接收面积的直径为1mm,从仿真和实验结果表明该方法适用于“非完备投影数据”的光声层析成像。从图像重建效果上与滤波反投影算法相比较,该成像算法提高了重建图像的分辨率和对比度。采用代数重建算法的有限角度的光声成像方法,对临床医学的无损伤检测,具有重要的意义。     

基于长焦区聚焦换能器的扫描光声乳腺成像技术

报道了一种利用长焦区聚焦超声换能器检测光声信号的扫描光声乳腺成像系统.通过增加聚焦换能器焦区的长度,该技术可以快速实现对大块组织(如乳腺)的光声成像.测试结果表明,该实验系统能够对大块模拟样品中吸收体的位置、尺寸以及光能量吸收情况实现较为准确的成像.另外,实验中,该系统还可便捷地与传统的超声技术相结合,从而实现多模式复合的乳腺癌诊断.初步结果显示了该技术路线在乳腺癌早期诊断应用上的前景. 关键词： 乳腺癌诊断 光声成像 扫描光声层析术 脉冲回波法     

Bridging the terahertz near-field and far-field observations of liquid crystal based metamaterial absorbers

Metamaterial-based absorbers play a significant role in applications ranging from energy harvesting and thermal emitters to sensors and imaging devices.The middle dielectric layer of conventional metamaterial absorbers has always been solid.Researchers could not detect the near field distribution in this layer or utilize it effectively.Here,we use anisotropic liquid crystal as the dielectric layer to realize electrically fast tunable terahertz metamaterial absorbers.We demonstrate strong,position-dependent terahertz near-field enhancement with sub-wavelength resolution inside the metamaterial absorber.We measure the terahertz far-field absorption as the driving voltage increases.By combining experimental results with liquid crystal simulations,we verify the near-field distribution in the middle layer indirectly and bridge the nearfield and far-field observations.Our work opens new opportunities for creating high-performance,fast,tunable,terahertz metamaterial devices that can be applied in biological imaging and sensing.     

基于数字微镜的快速轴向扫描系统

为解决双光子荧光显微成像系统轴向扫描问题,提出一种基于数字微镜(DMD)的快速轴向扫描系统。该系统采用DMD选择光路,不同光路放置不同焦距的透镜组对光束发散角产生不同的改变,经物镜聚焦后得到不同深度的轴上扫描点。对该系统的轴向扫描距离、扫描点位置及衍射效率进行了理论计算仿真,结果表明:扫描系统采用4个模块以及5个模块时其轴向扫描距离均可达到1 mm,4模块系统中透镜的焦距为297.3 mm,5模块系统中透镜焦距为361.47 mm。轴向扫描点除边缘点外线性分布, 轴向扫描频率达到几十kHz,满足脑神经成像的要求。     

Wavefront analysis for plenoptic camera imaging

The plenoptic camera is a single lens stereo camera which can retrieve the direction of light rays while detecting their intensity distribution. In this paper, to reveal more truths of plenoptic camera imaging, we present the wavefront analysis for the plenoptic camera imaging from the angle of physical optics but not from the ray tracing model of geometric optics.Specifically, the wavefront imaging model of a plenoptic camera is analyzed and simulated by scalar diffraction theory and the depth estimation is redescribed based on physical optics. We simulate a set of raw plenoptic images of an object scene, thereby validating the analysis and derivations and the difference between the imaging analysis methods based on geometric optics and physical optics are also shown in simulations.     

频域OCT的背向散射率补偿

针对频域OCT中背向散射光的强度随探测深度加深而急剧减弱,从而导致最后的组织成像模糊不清的现象,提出了一种对不同探测深度图像灰度补偿的方法。该方法通过补偿样品每层析面的入射光功率与背向功率散射率,来得到样品每层析面图像的真实灰度,提高了OCT图像质量。以理想的、由多层均匀介质组成的组织模型为基础,深入剖析了影响深度图像灰度的主要因素。通过建立以多层盖玻片为被测物体的频域OCT系统,得到多层盖玻片的深度图像。在对以盖玻片为被测物体的前提下,得出逐层深度图像灰度补偿的公式。并将理论补偿和实验系统的复杂情况相结合,对深度灰度图像进行入射和出射光强的补偿。实验结果证明这种补偿法是一种有效可行的补偿方法。     

Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography

We developed a miniature endoscope that is capable of rapid lateral scanning and is suitable for real-time forward-imaging optical coherence tomography (OCT). The endoscope has an outer diameter of 2.4 mm, consisting of a miniature tubular lead zirconate titanate (PZT) actuator, a single-mode fiber-optic cantilever, and a graded-index lens. Rapid lateral scanning at 2.8 kHz is achieved when the fiber-optic cantilever is resonated with the PZT actuator. This allows OCT imaging to be performed by fast lateral beam scanning followed by slow depth scanning, which is different from the conventional OCT imaging sequence. Real-time OCT imaging with the endoscope operated in the new image acquisition sequence at 6 frames/s is demonstrated.