共查询到20条相似文献,搜索用时 894 毫秒
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有机硅化合物具有重要用途,被广泛应用于材料科学与药物化学等领域.因此,有机硅试剂参与的化学转化一直倍受关注.近年来,可见光催化迅速发展,为有机合成化学提供了新的机遇.在光氧化还原体系下,有机硅试剂可以经由氢原子转移(Hydrogen atom transfer,HAT)或单电子转移(Single electron transfer,SET)过程转化为硅自由基或碳自由基进行反应,具有条件温和、选择性好和原子经济性高等优势.根据反应类型不同,主要综述了有机硅试剂作为硅自由基前体参与的烯(炔)烃硅氢化反应、烯(炔)烃双官能化反应、氮杂芳烃的硅基化反应,以及有机硅化合物作为碳自由基前体参与的亲核加成反应、Minisci反应、均裂取代反应和过渡金属介导的交叉偶联反应. 相似文献
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含二茂铁核的硅有机衍生物的合成 总被引:2,自引:0,他引:2
合成了一系列含二茂铁核的硅有机衍生物.试图从环戊二烯基三甲基硅烷与FeCl2在二乙胺存在下制取1,1'-双(三甲基硅烷基)二茂铁,由于Si-C键的断裂,未获预期产物而得二茂铁. 为了合成双有机硅基二茂铁,采用了两种方法.方法之一是从1,1'-二茂铁二钠与相应的三烷基氯硅烷反应制得1,1'-双(三甲基硅烷基)二茂铁、1,1'-双(三丁基硅烷基)二茂铁和1,1'-双(二甲基苯基硅烷基)二茂铁.为了取得单取代硅烷基二茂铁,采用二茂铁锂,但一般得单和双取代衍生物的混合物,它们很难分离;如减少有机氯硅烷用量,则可得纯的单取代乙烯基二乙基硅烷基二茂铁.另一方法是将三甲基-γ-氯丙基硅烷的格氏试剂与二乙酰基二茂铁反应制得含二茂铁核的双叔醇. 相似文献
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目前生物有机硅化学已经形成了有机硅化学的一个新的研究领域,已发现大批具有较高和某些专门的生物活性的有机硅化合物。我们对一些酰氧基类型有机硅化合物的毒性进行了研究,总结了毒性和结构关系,发现其毒性一般都比相应的不含硅的母体化合物低;研究了某些有机硅的取代苯氧乙酸酯的生物活性及水杨酰替苯胺类型的有机硅化合物。本文合成了一系列新的2-呋喃甲酰胺类型的有机硅化合物,研究了它们对一些植物病原菌的抗菌活性,探讨了其结构与抗菌活性的关系. 相似文献
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A small series of organosilicon compounds were screened for efficacy against the housefly Musca domestica. The activity of organosilicon compounds is attributed to the silicon atom, the presence of halogens and the alkyl groups. 相似文献
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硅杂四元环化合物的合成和反应 总被引:1,自引:0,他引:1
硅杂四元环化合物在有机硅化学中是一类非常重要的小分子环系化合物, 广泛应用于有机化学、金属有机化学以及材料化学. 环上只含有一个硅原子的硅杂环丁烷可以通过γ-卤代丙基硅烷的Grignard反应、Si=C键与烯烃的 [2+2]环加成反应以及硅杂环丙烷的扩环反应合成, 环上只含有一个硅原子的硅杂环丁烯可以通过格氏试剂或锂试剂参与的Si—C键的关环反应、硅杂环丁烷的转化反应、硅卡宾对C—H键的插入反应、Si=C键与炔烃的[2+2]环加成反应以及二炔基硅烷的分子内成环反应等途径合成. 硅杂环丁烷和硅杂环丁烯由于存在环张力和具有一定的Lewis酸性, 能够通过扩环反应生成五元和六元含硅杂环化合物, 也能够通过开环反应生成不同结构的有机硅分子和聚合物, 抑或实现有机反应在温和条件下的转化. 相似文献
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The drug molecule is called as silα-drug if one carbon atom is substituted by silicon atom in the organic-drugs. Generally, drugs of this kind have low toxicity and pro-long efficiency. People have designed many methods in order to decrease the toxicity of organotin compounds and organosilicon has proved to be effective. Torque[1] is a new acaricide made by Shell company in America, its structure is[(PhMe2CCH2)3SnI2O. R. Tacke[2] from Germany synthesized the compounds (PhMe2SiCH2)3SnX[X=HO, (PhMe2SiCH2)3SnO] and tested the acaricidal activity of[(PhMe2EICH2)3Sn]2O (EI=C, Si) in 1986. He proved that the silyl-derivatives of Torque were highly effective acaricides. 相似文献
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The photolysis of carbon tetrachloride in the presence of a number of organosilicon compounds has been investigated in the gas phase. The products obtained from the photolysis experiments were those expected from a chain reaction in which trichloromethyl radicals abstract hydrogen atoms from the organosilane. Arrhenius parameters for hydrogen atom transfer were determined relative to those for trichloromethyl radical combination. The activation energies for the reaction of methyl, trifluoromethyl, and trichloromethyl radicals with organosilicon compounds are compared and the results rationalized in terms of polar effects. 相似文献
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具有生物活性的有机硅化合物研究近况 总被引:7,自引:0,他引:7
生物有机硅化合物的研究进展迅速,而且越来越受到人们的重视。实际上,它是有机硅化学的一个新的分支。本文对有机硅化合物的毒理学、有机硅药物化学以及有机硅农药作了简要的论述。 相似文献
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Calculation of 1J(13C-29si) spin-spin coupling constants by the maximum overlap approximation method
The spin-spin 1J(C-Si) coupling constants were calculated by the maximum overlap approximation method for a series of related organosilicon compounds. It was concluded that the variation in hybridization of the relevant carbon atom accounts for the changes in 1J(C-Si) observed experimentally. 相似文献
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Anu Ploom 《Journal of organometallic chemistry》2009,694(3):313-315
A revision of quantitative literature data for the reactivity of organosilicon compounds in light of conceptions stemmed from organic chemistry has been carried out. It has been found that in structure-reactivity analysis for organosilicon compounds, differently of carbon compounds, the inductive effect of substituents, at least in nucleophilic displacement reactions at silicon, must be expressed by two terms involving that for electronegativity. A protocol for the correlation analysis in organosilicon chemistry is now available. 相似文献
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A general method for the preparation of organosilicon lactones and lactams in which a silicon atom attached to two carbon atoms is present in the -position to the heteroatom O or N has been developed. A new reaction with acyloxysilanes has been observed for a number of silicon compounds containing a chloromethyl radical, which consists in the replacement of the chlorine by the acyl radical. 相似文献
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6-Membered ring organosilicon lactones, with various substituants on the silicon atom, are prepared. 相似文献