21世纪是信息科学、合成化学和生命科学共同繁荣的世纪

从几个不同的角度阐述了21世纪是信息科学、合成化学和生命科学共同繁荣的世纪。（1）社会和青年学生对化学的质疑；（2）20世纪的化学取得了空前辉煌的成就；（3）20世纪发明了七大技术，最重要的是信息技术、化学合成技术和生物技术；（4）21世纪是信息科学、合成化学和生命科学共同繁荣的世纪；（5）化学是一门社会迫切需要的中心科学，她与生命、材料、信息、环境、能源等新兴科学都有非常密切的联系，产生了许多重要的交叉学科，但化学作为中心学科的形象反而被其交叉学科的巨大成就所埋没；（6）化学有没有理论；（7）21世纪化学的四大难题；（8）解决了化学的四大世纪难题后的美好前景；（9）21世纪的化学不但要认识世界、改造世界，而且还要保护世界；（10）我国化学基础研究取得了显著进展；（11）几点希望和建议。     

化学走出地球——2018年美国国家化学周活动介绍

简要介绍美国国家化学周的历史发展和活动特点，重点介绍"化学走出地球"实验活动，并对科学阅读、采访未来化学家等活动板块作简要说明。结合本次活动特点，联系我国化学教育实际，得出了几点启示：（1）设计实验，强化证据意识；（2）鼓励实践，加深化学本质理解；（3）构建模型，突出项目学习；（4）协同育人，推进科教结合；（5）强调阅读，关注学科动态；（6）融合科技，培养原子思维。     

冯长根教授招收硕士博士生

根据科研工作和培养人才需要，北京理工大学冯长根教授招收具有化学学科背景的硕士博士生若干名。欢迎应届或历届毕业生报考。研究课题为：（１）汽车尾气催化净化剂化学；（２）植物医药的化学研究；（３）加速量热仪（ＡＲＣ）在化学物品的化学安全性稳定性及有关性能中的应用；（４）非线性化学动力学；（５）燃烧化学（含爆炸化学）；（６）固体中的快速化学反应；（７）小型微型器件中的化学。报考者请与冯长根教授联系。地址：北京理工大学机电工程学院　　邮编：１０００８１电话：０１０－６８９１２７６４　　传真：０１０－６８９…     

钴（III）咔咯合成与应用研究进展

综述了不同类型咔咯自由碱及其金属钴（III）配合物的合成方法，并分类探讨了不同类型的金属钴（III）咔咯在能源化学与环境化学领域的应用，包括（1）电化学催化氧气还原；（2）分子传感器；（3）有机氯污染物降解；（4）烯烃催化氧化。同时，对钴（III）咔咯化学未来的发展方向进行了展望。     

不惑之年更进一步

不惑之年更进一步中国科学院化学研究所创建于１９５６年，是中国科学院早期成立的研究所之一，是化学领域内的一个多学科的综合性研究所。当前有４个主要学科领域：（１）物理化学；（２）高分子化学与物理（包括高分子材料科学）；（３）有机化学；（４）分析化学。全所...     

Pittcon 2005国际分析会议(三)暨第10次关于痕量金属形态的分析方法论进展国际研讨会

2005年Pittcon会议续报如下：生物材料表面和界面的化学成像技术组报告有：（1）DG Castner，应用x射线的生物和有机物表面的成像技术——光发射电子显微术和x射线光电子能谱技术的研究；（2）N Winograd，应用聚束表面电离质谱技术进行单个生物细胞的三维化学成像的前景；（3）R MCorn，供蛋白质和脱氧核糖核酸微阵列用的酶法表面等离子体激元共振成像技术；（4）B Hagenhoff，生物材料表面和界面的化学成像技术；（5）PS Weiss，膜-细胞骨架和膜-表面相互作用的物理模型。     

AlN粉末合成研究进展

综述了国内外ＡｌＮ粉末合成的最新进展，内容涉及ＡｌＮ粉末合成的主要方法和表面处理。包括：（１）铝粉直接氮化法；（２）化学气相积法；（３）碳热还原法；（４）裂解法；（５）表面处理。     

论化学对象的历史演化

论化学对象的历史演化廖正衡（辽宁师范大学科学史所，大连１１６０２２）周广东（辽宁教育出版社，沈阳１１０００１）化学对象，从客观上来看是物质的化学运动即物质分子的转变运动，这是不变的；然而从主观上来看，由于人们在不同历史发展时期对于化学运动和化学科学认...     

计算机化学应用软件介绍

计算机化学应用软件介绍忻新泉，洪汇孝（南京大学化学系２１０００８）编者按：随着计算机应用的发展和普及，计算机与化学的关系愈来愈密切、愈来愈受到重视。化学专用的软件包已大量出现；辅助化学教学的ＣＡＩ软件也层出不穷、各具特色、广泛应用；各高等院校在教学管...     

荧光法用于新型抗癌配合物pd（tcd）（NO3）2初步筛选及作用机制研究

荧光法用于新型抗癌配合物Ｐｄ（ｔｃｄ）（ＮＯ３）２初步筛选及作用机制研究李志良ａｂ毕琼斯ａ李俊忠ａｂ熊劲芳ａ林辉祥ａｂ俞汝勤ａ（ａ湖南大学化学化工系长沙４１００８２；ｂ湖南大学化学生物医药研究所长沙４１００８２）化学药物治疗是治疗癌症的重要手段之一，...     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Microwave-assisted copper-catalyzed stereoselective ring expansion of three-membered heterocycles with α-diazo-β-dicarbonyl compounds

Microwave-assisted copper-catalyzed ring expansions of three-membered heterocycles with α-diazo-β-dicarbonyl compounds were investigated. Thiiranes generated 3-acyl-5,6-dihydro-1,4-oxathiines in the presence of copper sulfate and trans-3-acyl-5,6-dihydro-1,4-oxathiines as stereospecific products for 1,2-disubstituted cis-thiiranes through an intramolecular S_N2 process. Oxiranes gave rise to 2-acyl-5,6-dihydro-1,4-dioxines under the catalysis of copper hexafluoroacetylacetonate and cis-3-acyl-5,6-dihydro-1,4-dioxines as stereospecific products for 1,2-disubstituted cis-oxiranes via an intimate ion-pair mechanism. The current method provides a direct and simple strategy in efficient preparation of 3-acyl-5,6-dihydro-1,4-oxathiines and 2-acyl-5,6-dihydro-1,4-dioxines, important agents in medicinal and agricultural chemistry, from readily available thiiranes and oxiranes, respectively.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.